Difference between revisions of "NONHSAT033797"

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DLEU1 maps to a critical region at chromosomal band 13q14.3 which is recurrently deleted in solid tumors and hematopoietic malignancies like chronic lymphocytic leukemia (CLL).
  
 
==Annotated Information==
 
==Annotated Information==
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===Transcriptomic Nomeclature===
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===Name===
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Please input transcriptomic nomeclature information here.
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[[File:Model of the tumor suppressor mechanism localized in 13q14.3.jpg|right|thumb|300px|'''Model of the tumor suppressor mechanism localized in 13q14.3'''<ref name="ref3" />.]]
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''DLEU1'':deleted in lymphocytic leukemia 1 (non-protein coding)(HGNC nomenclature)
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''BCMS''<ref name="ref1" />, “deleted in lymphocytic leukemia, 1”<ref name="ref1" />, ''DLB1''<ref name="ref1" />,"B-cell neoplasia-associated gene with multiple splicing"<ref name="ref1" />, ''BCMS1''<ref name="ref1" />,LEU1<ref name="ref2" />, LINC00021<ref name="ref2" />, "long intergenic non-protein coding RNA 21"<ref name="ref2" />, NCRNA00021<ref name="ref2" />, "non-protein coding RNA 21"<ref name="ref2" />, XTP6<ref name="ref2" />
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''DLEU1'': deleted in lymphocytic leukemia 2 (non-protein coding)(HGNC nomenclature)
  
 
===Function===
 
===Function===
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DLEU1 or DLEU2 exert their function by binding to chromatin, but rather regulate the neighboring cluster of candidate tumor suppressor genes by divergent transcription <ref name="ref3" />
  
 
===Regulation===
 
===Regulation===
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[[File:Downregulation of 13q14.3 candidate tumor suppressor genes and upregulation of lncRNA genes DLEU1 and DLEU2correlates with DNA-methylation.jpg|right|thumb|300px|'''Downregulation of 13q14.3 candidate tumor suppressor genes and upregulation of lncRNA genes DLEU1 and DLEU2correlates with DNA-methylation.'''<ref name="ref3" />]]
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It was regulated by DNA-methylation and histone modifications<ref name="ref3" />.
  
 
===Expression===
 
===Expression===
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Both lncRNA genes DLEU1 and DLEU2/Alt1 were upregulated in Jurkat cells upon DNA-demethylation in-vitro , underlining that their transcriptional activity depends on levels of DNA-methylation.<ref name="ref3" />
  
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===Allelic Information and Variation===
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===Disease===
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Please input allelic information and variation information here.
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hematopoietic and solid tumors<ref name="ref3" />
  
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===Evolution===
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==Labs working on this lncRNA==
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Abteilung Organisation Komplexer Genome (H0700), Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, D-69120 Heidelberg, Germany.<ref name="ref1" />
  
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Radiumhemmet, Karolinska Hospital, Stockholm, Sweden.<ref name="ref2" />
  
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==Labs working on this lncRNA==
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Cooperation Unit "Mechanisms of Leukemogenesis," University Ulm, German Cancer Research Center, DKFZ, Heidelberg, Germany.<ref name="ref3" />
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Please input related labs here.
 
  
 
==References==
 
==References==
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<references>
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<ref name="ref1">Wolf S, Mertens D, Schaffner C, Korz C, Dohner H, Stilgenbauer S, et al. B-cell neoplasia associated gene with multiple splicing (BCMS): the candidate B-CLL gene on 13q14 comprises more than 560 kb covering all critical regions[J]. Human molecular genetics. 2001,10(12):1275-85.</ref>(1)
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<ref name="ref2">Liu Y, Corcoran M, Rasool O, Ivanova G, Ibbotson R, Grander D, et al. Cloning of two candidate tumor suppressor genes within a 10 kb region on chromosome 13q14, frequently deleted in chronic lymphocytic leukemia[J]. Oncogene. 1997,15(20):2463-73.</ref>(2)
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<ref name="ref3">Garding A, Bhattacharya N, Claus R, Ruppel M, Tschuch C, Filarsky K, et al. Epigenetic upregulation of lncRNAs at 13q14.3 in leukemia is linked to the In Cis downregulation of a gene cluster that targets NF-kB[J]. PLoS genetics. 2013,9(4):e1003373</ref>(3)
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</references>
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{{basic|
 
{{basic|
 
tID = NONHSAT033797|
 
tID = NONHSAT033797|
 
source = NONCODE4.0|
 
source = NONCODE4.0|
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same = ,|
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same = ''DLEU1'',''BCMS'', “deleted in lymphocytic leukemia, 1”, ''DLB1',"B-cell neoplasia-associated gene with multiple splicing", ''BCMS1'',''LEU1'', ''LINC00021'', "long intergenic non-protein coding RNA 21", NCRNA00021, "non-protein coding RNA 21", ''XTP6''|
 
classification = intergenic|
 
classification = intergenic|
 
length = 1374 nt|
 
length = 1374 nt|
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sequence = <dnaseq>TTCATTCATCAAAGATTTATTGAGTGCTTACTGTGTGCCAGGCACTGTTCTAAAGACACAGCAGCAAACAAAACTGTTATAGAACAGGATAAGGCAGGTCATCTCCCAGATACGACACTTTGATAGGAACACAAAATACAAATAGGAGAGTAGAAAGAGATGAAATACAAAGAGAAAGAGCTGATATTGGGCTTATATTAATATTGAAAGGCCTTACATGCTAGATATTCTAAATGGGAGAAACATGCTGGAAAGATACTTGGCATGAATGAACTTATGTCCCTATGTTCAGAACAGACTGCTTTCCCTTCTCTGTTGGTTGGCTCTTCTAGCCTCCTAGGAACTTTTATAATCACCAGTATGATCCAATATAAATACTGCACATATGAAGGTTCCCAGTTGAGGAGTTTGGAAGCAAAAAGGGAAAGAATGGCTGGCAAAGGCTTCAATCTTCTGTCTCCTTTTATCTTCCCAATGGCTAGTAGAAAATACTATCATCAATCTCTTCCTTGCAACAATCTCCCATTTGATATTTGTCTGCATTGTGACTCAATTCCTGAAGGTTCTGTTCTTCATTCCTTTCTGGTAGAATCAGGAGCCTCAGCGCTTTCGGCGCCATTTTCGAGTGATGCCTGATCTCATCAATCTAGCGGGAGAGACAGGATAACCTGTCCGAGAGTATAGCGCCACTATGACTCCGCCGGAAAAATTACTTTAAAAATCGCCAAAAATTACTTGGAGCAAAGGGCAGTCGGCGGAGCTTCGCCAAGGCTGGCGCAGTCGGTTTTGACCTGTAGCAGAGAACCAATTCTGGAGAACAGCCTCACTTCTTTGATTGAATACTTACATAATGCATTGGAACATGACATGAGATTAAGAGGTTTAATAATGATAGAATGAAGACCACAATAAAAGAGACCTCTACTTAGCTCAGCAATTCTTACCTTAGTCTTACCTATTTGATGAAGATGTCTTTTGAAAGGTGTACTGCAAGGAACAAAATGTTTGTAAATTCTCCTTTTACCAAGAGGTGGATAATTACTGTACCTTCCTCATGGAAAAAGTTTTATTTAAAGTGTTATTTCTCATTGAATACTATCAAAAAGGAAAAAAAAATGACCTAAACTTTTGAGATAGATTTGGCTCTAGTAAGTATTTAGTTATATCACTTGCATATCTGGGAGAAGAAATAAGAGACTATCATCAGTACATTCCCATCTACTAAAAAAATTTATTTTACACATGTCAAGGGATTACTTATAACTTCCATTTTATTACTAATAGCTTGAACCCTTTTAATGAAGACCTAACTCCTCCACCAGAAATTTAAGTTTATGTTCTTACTTTGTTTACTTATAAAATACATCTCAGGTA</dnaseq>|
 
sequence = <dnaseq>TTCATTCATCAAAGATTTATTGAGTGCTTACTGTGTGCCAGGCACTGTTCTAAAGACACAGCAGCAAACAAAACTGTTATAGAACAGGATAAGGCAGGTCATCTCCCAGATACGACACTTTGATAGGAACACAAAATACAAATAGGAGAGTAGAAAGAGATGAAATACAAAGAGAAAGAGCTGATATTGGGCTTATATTAATATTGAAAGGCCTTACATGCTAGATATTCTAAATGGGAGAAACATGCTGGAAAGATACTTGGCATGAATGAACTTATGTCCCTATGTTCAGAACAGACTGCTTTCCCTTCTCTGTTGGTTGGCTCTTCTAGCCTCCTAGGAACTTTTATAATCACCAGTATGATCCAATATAAATACTGCACATATGAAGGTTCCCAGTTGAGGAGTTTGGAAGCAAAAAGGGAAAGAATGGCTGGCAAAGGCTTCAATCTTCTGTCTCCTTTTATCTTCCCAATGGCTAGTAGAAAATACTATCATCAATCTCTTCCTTGCAACAATCTCCCATTTGATATTTGTCTGCATTGTGACTCAATTCCTGAAGGTTCTGTTCTTCATTCCTTTCTGGTAGAATCAGGAGCCTCAGCGCTTTCGGCGCCATTTTCGAGTGATGCCTGATCTCATCAATCTAGCGGGAGAGACAGGATAACCTGTCCGAGAGTATAGCGCCACTATGACTCCGCCGGAAAAATTACTTTAAAAATCGCCAAAAATTACTTGGAGCAAAGGGCAGTCGGCGGAGCTTCGCCAAGGCTGGCGCAGTCGGTTTTGACCTGTAGCAGAGAACCAATTCTGGAGAACAGCCTCACTTCTTTGATTGAATACTTACATAATGCATTGGAACATGACATGAGATTAAGAGGTTTAATAATGATAGAATGAAGACCACAATAAAAGAGACCTCTACTTAGCTCAGCAATTCTTACCTTAGTCTTACCTATTTGATGAAGATGTCTTTTGAAAGGTGTACTGCAAGGAACAAAATGTTTGTAAATTCTCCTTTTACCAAGAGGTGGATAATTACTGTACCTTCCTCATGGAAAAAGTTTTATTTAAAGTGTTATTTCTCATTGAATACTATCAAAAAGGAAAAAAAAATGACCTAAACTTTTGAGATAGATTTGGCTCTAGTAAGTATTTAGTTATATCACTTGCATATCTGGGAGAAGAAATAAGAGACTATCATCAGTACATTCCCATCTACTAAAAAAATTTATTTTACACATGTCAAGGGATTACTTATAACTTCCATTTTATTACTAATAGCTTGAACCCTTTTAATGAAGACCTAACTCCTCCACCAGAAATTTAAGTTTATGTTCTTACTTTGTTTACTTATAAAATACATCTCAGGTA</dnaseq>|
 
}}
 
}}
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[[Category:Intergenic]][[Category:NONHSAG013515]]
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[[Category:Intergenic]][[Category:NONHSAG013515]][[Category:Transcripts]]

Latest revision as of 12:47, 30 June 2016

DLEU1 maps to a critical region at chromosomal band 13q14.3 which is recurrently deleted in solid tumors and hematopoietic malignancies like chronic lymphocytic leukemia (CLL).

Annotated Information

Name

Model of the tumor suppressor mechanism localized in 13q14.3[1].

DLEU1:deleted in lymphocytic leukemia 1 (non-protein coding)(HGNC nomenclature)

BCMS[2], “deleted in lymphocytic leukemia, 1”[2], DLB1[2],"B-cell neoplasia-associated gene with multiple splicing"[2], BCMS1[2],LEU1[3], LINC00021[3], "long intergenic non-protein coding RNA 21"[3], NCRNA00021[3], "non-protein coding RNA 21"[3], XTP6[3]

DLEU1: deleted in lymphocytic leukemia 2 (non-protein coding)(HGNC nomenclature)

Function

DLEU1 or DLEU2 exert their function by binding to chromatin, but rather regulate the neighboring cluster of candidate tumor suppressor genes by divergent transcription [1]

Regulation

Downregulation of 13q14.3 candidate tumor suppressor genes and upregulation of lncRNA genes DLEU1 and DLEU2correlates with DNA-methylation.[1]

It was regulated by DNA-methylation and histone modifications[1].

Expression

Both lncRNA genes DLEU1 and DLEU2/Alt1 were upregulated in Jurkat cells upon DNA-demethylation in-vitro , underlining that their transcriptional activity depends on levels of DNA-methylation.[1]

Disease

hematopoietic and solid tumors[1]

Labs working on this lncRNA

Abteilung Organisation Komplexer Genome (H0700), Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, D-69120 Heidelberg, Germany.[2]

Radiumhemmet, Karolinska Hospital, Stockholm, Sweden.[3]

Cooperation Unit "Mechanisms of Leukemogenesis," University Ulm, German Cancer Research Center, DKFZ, Heidelberg, Germany.[1]

References

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Garding A, Bhattacharya N, Claus R, Ruppel M, Tschuch C, Filarsky K, et al. Epigenetic upregulation of lncRNAs at 13q14.3 in leukemia is linked to the In Cis downregulation of a gene cluster that targets NF-kB[J]. PLoS genetics. 2013,9(4):e1003373
  2. ↑ 2.0 2.1 2.2 2.3 2.4 2.5 Wolf S, Mertens D, Schaffner C, Korz C, Dohner H, Stilgenbauer S, et al. B-cell neoplasia associated gene with multiple splicing (BCMS): the candidate B-CLL gene on 13q14 comprises more than 560 kb covering all critical regions[J]. Human molecular genetics. 2001,10(12):1275-85.
  3. ↑ 3.0 3.1 3.2 3.3 3.4 3.5 3.6 Liu Y, Corcoran M, Rasool O, Ivanova G, Ibbotson R, Grander D, et al. Cloning of two candidate tumor suppressor genes within a 10 kb region on chromosome 13q14, frequently deleted in chronic lymphocytic leukemia[J]. Oncogene. 1997,15(20):2463-73.


Basic Information

Transcript ID

NONHSAT033797

Source

NONCODE4.0

Same with

DLEU1,BCMS, “deleted in lymphocytic leukemia, 1”, DLB1',"B-cell neoplasia-associated gene with multiple splicing", BCMS1,LEU1, LINC00021, "long intergenic non-protein coding RNA 21", NCRNA00021, "non-protein coding RNA 21", XTP6

Classification

intergenic

Length

1374 nt

Genomic location

chr13-:50618561..50679433

Exon number

6

Exons

50618561..50618906,50623720..50623800,50642233..50642301,50649695..50649789,50655959..50656147,50678840..50679433

Genome context

Sequence
000001 TTCATTCATC AAAGATTTAT TGAGTGCTTA CTGTGTGCCA GGCACTGTTC TAAAGACACA GCAGCAAACA AAACTGTTAT 000080
000081 AGAACAGGAT AAGGCAGGTC ATCTCCCAGA TACGACACTT TGATAGGAAC ACAAAATACA AATAGGAGAG TAGAAAGAGA 000160
000161 TGAAATACAA AGAGAAAGAG CTGATATTGG GCTTATATTA ATATTGAAAG GCCTTACATG CTAGATATTC TAAATGGGAG 000240
000241 AAACATGCTG GAAAGATACT TGGCATGAAT GAACTTATGT CCCTATGTTC AGAACAGACT GCTTTCCCTT CTCTGTTGGT 000320
000321 TGGCTCTTCT AGCCTCCTAG GAACTTTTAT AATCACCAGT ATGATCCAAT ATAAATACTG CACATATGAA GGTTCCCAGT 000400
000401 TGAGGAGTTT GGAAGCAAAA AGGGAAAGAA TGGCTGGCAA AGGCTTCAAT CTTCTGTCTC CTTTTATCTT CCCAATGGCT 000480
000481 AGTAGAAAAT ACTATCATCA ATCTCTTCCT TGCAACAATC TCCCATTTGA TATTTGTCTG CATTGTGACT CAATTCCTGA 000560
000561 AGGTTCTGTT CTTCATTCCT TTCTGGTAGA ATCAGGAGCC TCAGCGCTTT CGGCGCCATT TTCGAGTGAT GCCTGATCTC 000640
000641 ATCAATCTAG CGGGAGAGAC AGGATAACCT GTCCGAGAGT ATAGCGCCAC TATGACTCCG CCGGAAAAAT TACTTTAAAA 000720
000721 ATCGCCAAAA ATTACTTGGA GCAAAGGGCA GTCGGCGGAG CTTCGCCAAG GCTGGCGCAG TCGGTTTTGA CCTGTAGCAG 000800
000801 AGAACCAATT CTGGAGAACA GCCTCACTTC TTTGATTGAA TACTTACATA ATGCATTGGA ACATGACATG AGATTAAGAG 000880
000881 GTTTAATAAT GATAGAATGA AGACCACAAT AAAAGAGACC TCTACTTAGC TCAGCAATTC TTACCTTAGT CTTACCTATT 000960
000961 TGATGAAGAT GTCTTTTGAA AGGTGTACTG CAAGGAACAA AATGTTTGTA AATTCTCCTT TTACCAAGAG GTGGATAATT 001040
001041 ACTGTACCTT CCTCATGGAA AAAGTTTTAT TTAAAGTGTT ATTTCTCATT GAATACTATC AAAAAGGAAA AAAAAATGAC 001120
001121 CTAAACTTTT GAGATAGATT TGGCTCTAGT AAGTATTTAG TTATATCACT TGCATATCTG GGAGAAGAAA TAAGAGACTA 001200
001201 TCATCAGTAC ATTCCCATCT ACTAAAAAAA TTTATTTTAC ACATGTCAAG GGATTACTTA TAACTTCCAT TTTATTACTA 001280
001281 ATAGCTTGAA CCCTTTTAAT GAAGACCTAA CTCCTCCACC AGAAATTTAA GTTTATGTTC TTACTTTGTT TACTTATAAA 001360
001361 ATACATCTCA GGTA
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