Difference between revisions of "NONHSAT011777"

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==References==
 
==References==
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[http://www.lncrnadb.org/PRINS/ Annotation originally sourced from lncRNAdb.]
  
 
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Revision as of 03:41, 26 August 2015

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Annotated Information

Name

PRINS: Psoriasis susceptibility-related RNA Gene Induced by Stress.

Characteristics

~3.6 kb, transcribed by RNA Polymerase II; spliced (2 exons) and polyadenylated (Sonkoly (2005)).

Function

siRNA knock-down shows that PRINS is required for cell viability after serum starvation (Sonkoly (2005)), and also alters cell morphology and gene expression (Szegedi (2010)). Elevated PRINS expression in the epidermis is suggested to contribute to psoriasis susceptibility (Sonkoly (2005)). In keratinocytes PRINS regulates the expression of the G1P3 gene, an anti-apoptotic protein that is overexpressed in psoriasis (Szegedi (2010)), although the mechanism is unknown.

Expression

Elevated expression in psoriatic epidermis. Regulated by the proliferation and differentiation state of keratinocytes (Sonkoly (2005)). Expressed at different levels in various human tissues, with highest levels detected in veins (Sonkoly (2005)). Several stress signals such as ultraviolet-B (UV-B) irradiation, viral infection (herpes simplex virus), and translational inhibition increased the RNA level of PRINS (Sonkoly (2005)), as well as HaCaT keratinocyte cell treatment with microbial agents such as bacteria peptidoglycan, lipopolysaccharide (LPS) and wall extract (Bari (2011)).

Conservation

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Misc

PRINS RNA contains contains two Alu elements, as well as a short sequence stretch with ~70% similarity to an element in a small cytoplasmic noncoding RNA, named G8, from Tetrahymena thermophila, whose expression responds to heat shock and is involved in thermotolerance (Sonkoly (2005)).

Transcriptomic Nomeclature

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Regulation

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Allelic Information and Variation

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Evolution

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Labs working on this lncRNA

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References

Annotation originally sourced from lncRNAdb.

Basic Information

Transcript ID

NONHSAT011777

Source

NONCODE4.0

Same with

,

Classification

intronic(S)

Length

2199 nt

Genomic location

chr10+:24536054..24544975

Exon number

2

Exons

24536054..24537320,24544051..24544975

Genome context

Sequence
000001 GGCCTTTTTT TTTTTTTTTT TCAAATGCCC CTTTCATTAT GAAACTCTTT TTTAACTTTT AATTTAAGTT CAGGGGTATG 000080
000081 TGTGCAGATT TGTTACATAG GTAAACTTGT GTCATGGGGC TTTGTTGTAC AGGTTGTTTC ATCACCCAGG TATTATTTTA 000160
000161 TTTTCATTTT AGTTTTTTAA ATTTCTTTTT AGAGGCGGGG TCTCACTGTG TTTTGCCCAG GCTGGTCTCG AACTCCTCCT 000240
000241 GGTCTCAAGC AATCCTCTCG CCTCTGCCTC CCCAAGTGTT GGGATTATAG GCATGAGCTA CTGCACTCAG CCCACCATTT 000320
000321 GTTTTAAAAA GGGTGGATCC TATTTGTATA AAAAGCCATG TGCATTTTCT GTGTACTTGT CTACACATTA ATTTCCAGGC 000400
000401 TGGGCGTGGT GGCTCACGCT TGTAATCCCA GCACTTTGGG AGGCCAAGGG GAGGCAGATC ATGAGGTTAG GAGATCGAAA 000480
000481 CCATCCTGGC TAACACGGTG AAACCCCGTC TCTACTAAAA ATACAAAAAC AAAATTAGCA GGGTGTTGTG GCGGGCGCCT 000560
000561 GTAGTCCCAG CTACTCAGGA GGCTGAGGCA GGAGAATGGC ATGAACCCGG GAGGTGGAGC TTGCAGTGAG CTGAGATTGC 000640
000641 GCCACTGCCC TCCAGCCTGG ACAACAGAGT GAGGCTCCGT CTTAAAGGAA AAAAATTTCT GGAATGATGT CCAATAAATC 000720
000721 AGAGAGAGGG ACTAGAAGAC TAATGAGGAC AGAAGCTTTT ATTCTTAACA CCTATATTTT GCTACCATTT ATATTGTCAT 000800
000801 CATATGCATA TAACATTTTA ACATTTAAAA ACTAGTTTAA ACAGAAATGG TTGCCCTGGA ATGTGGCCTG TGTTCTTTCA 000880
000881 AGGGAGGCCA GCAGTTTCTA CAGTGGCTGA GATGGTACCT TCATCTCACA CACCTACGCA GGCGTGCATT TGTGCTTTGA 000960
000961 TGTGGTTGTC CCTTGAAGAA GGAAGCAGTT CTCTTTTTCT TTTTTCCCTT TTCCATTATA GGATCAGTCA CTTCTTGGGG 001040
001041 CATTAGTAGT CTCATTTCCA GTGGCATCTT CCCTTGGCAA AAGGAATCCC AGATAGGACC TCATCTTTCT AAACAAATGC 001120
001121 TGTTTTGGGT CCTAACCATC CCATGTTTGC TTTGAATATG TTTAAGTTGC CTGGAATTAT CAACAAAAGA ATTAAATTTA 001200
001201 TTGTAGGTCA GGGCATCTTT TGACTCATTG TATAAAACAT TCACTTTAAA TGTATACCGA AATGTCCTTT AGGCTGGGAT 001280
001281 TACAGGCATG AGCCATGACA CCCGGCCTGT AATTTTCTTT AAAGACTGCC ACTGGGTGGA ACCCACTGGG CCCAGTGAGA 001360
001361 ACTACGGAAA AGAGACCCAT TCTTGCCCTC ATTGTTAGTG TCCACATCCG GATTTACCTA AACCCCACCC AGGTGGCATT 001440
001441 TGCATAGTAA TGAAAAACCG GTATTTTCTA GCTGTGAATC ACACTTCAAA TCCTGAGCGG CTGACTGTCA GGGGTGCGTC 001520
001521 AGGCCTGCTT GCTGGGAGAA TGGACGAGCT GGTTGTGGAG CGGGCGGGTC CCGCCACCCG TGGGCTCAGC ACTGGACTGC 001600
001601 TCCCAGAACA TTAAAGGTCT GGCTGATGTT CCATGCCACA TCTGGACATG AAGACCCATG TCTGCCCTTC TGTAGAAGGG 001680
001681 CCAAAGAAGA AAGGAGGCAT CACATGTTTC TGCTGTGGGG GGCCCTTCCG AGCAGCAGAC AGGAGCAAGG TACAGGAGTG 001760
001761 GCCTGATTCT GGGGTTTCCC TGCCCCCCCT GGGGTCCCTA AACTGCTGTG TGATATGTTT CTAACTATCT GGACAGCTCA 001840
001841 CCCAAGAGTC AGTTGTTCCC AGTCGCTTCT TGCTGAGGAT AAGCCAAAAG AGGGCCGGGG GCCAATCTGG TTTCTTTCAA 001920
001921 GTGAAATTAT GCTTCTCAAG CAGAGAATGA TTGCCCACAG CAGTTAAACC TTGTTTAATG GTAATTAAAT TGCTTTTCTT 002000
002001 CACTTTGAAA AATCTCTTAA TTTTCTGTAC AAAGGCAGGA AGCATTTTTC TTTGATTCTA CAGGATGTTT CTAAGTATGG 002080
002081 TGTAATCAGT TCATCTTACC TTGCCGGGCT CTGAAAGAAT GAGTGTGTGG GATCAGATTT AGAAATGCCT CAAAGGTTAG 002160
002161 AAAGCCGAGT GCTGCCGATT AACTCAAGCT CAGATGACC
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Predicted Small Protein

Name NONHSAT011777_smProtein_860:1045
Length 62
Molecular weight 6886.93
Aromaticity 0.147540983607
Instability index 49.9245901639
Isoelectric point 6.37005615234
Runs 9
Runs residual 0.00527605049934
Runs probability 0.0602072660896
Amino acid sequence MWPVFFQGRPAVSTVAEMVPSSHTPTQACICALMWLSLEEGSSSLFLFSLFHYRISHFLG
H
Secondary structure LLEEELLLLLLEEEEEEELLLLLLHHHHHHHHHHHHLLLLLLLHHHHHHHHHHHHHHHLL
L
PRMN LLLLLLLLLLLLLLLLLLLLLLLLLLLLLLHHHHHHHHHHHHHHHHHHHHHHLLLLLLLL
L
PiMo ooooooooooooooooooooooooooooooTTTTTTTTTTTTTTTTTTTTTTiiiiiiii
i