Difference between revisions of "NONHSAT106529"

From LncRNAWiki
Jump to: navigation, search
(Function)
Line 10: Line 10:
 
[[File:FOXC1 and lncRNA-FOXCUT expression levels were elevated in metastatic ESCC and poorly differentiated tumor tissues.jpg|right|thumb|400px'''FOXC1 and lncRNA-FOXCUT expression levels were elevated in metastatic ESCC and poorly differentiated tumor tissues.'''<ref name="ref1" />]]
 
[[File:FOXC1 and lncRNA-FOXCUT expression levels were elevated in metastatic ESCC and poorly differentiated tumor tissues.jpg|right|thumb|400px'''FOXC1 and lncRNA-FOXCUT expression levels were elevated in metastatic ESCC and poorly differentiated tumor tissues.'''<ref name="ref1" />]]
  
FOXCUT that co-interacted with FOX1, may be functionally involved in the tumor progression and survival of ESCC patients, such as the upregulation of FOXC1 and FOXCUT were correlated with poor prognosis in ESCC patients, which may represent a potential prognostic biomarker and therapeutic target for ESCC patients <ref name="ref1" />.
+
''FOXCUT'' that co-interacted with FOXC1, may be functionally involved in the tumor progression and survival of ESCC patients, such as the upregulation of FOXC1 and FOXCUT were correlated with poor prognosis in ESCC patients, which may represent a potential prognostic biomarker and therapeutic target for ESCC patients <ref name="ref1" />.
  
 
===Diseases===
 
===Diseases===

Revision as of 16:09, 4 April 2015

FOXCUT,a novel long non-coding RNA FOXCUT ( FOXC1 promoter upstream transcript), which co-operated with its neighboring gene FOXC1 as lncRNA-mRNA pair, played a significant role in the oncogenesis and progression of esophageal squamous cell carcinoma (ESCC).

Annotated Information

Transcriptomic Nomeclature

FOXCUT,FOXC1 upstream transcript, FOXCUT (HGNC nomenclature)

"FOXC1 promoter upstream transcript", TCONS_00011636 [1]

Function

400pxFOXC1 and lncRNA-FOXCUT expression levels were elevated in metastatic ESCC and poorly differentiated tumor tissues.[1]

FOXCUT that co-interacted with FOXC1, may be functionally involved in the tumor progression and survival of ESCC patients, such as the upregulation of FOXC1 and FOXCUT were correlated with poor prognosis in ESCC patients, which may represent a potential prognostic biomarker and therapeutic target for ESCC patients [1].

Diseases

esophageal squamous cell carcinoma(ESCC) [1]

Expression

400pxThe expression of FOXC1 and FOXCUT.[1]

FOXC1 and FOXCUT were co-overexpressed in ESCC tissue specimens and ESCC cell lines. The expression of FOXCUT and FOXC1 (lncRNA-mRNA gene pair) were both identified to be upregulated in 82 ESCC tissues compared with adjacent noncancerous tissues, and the expression of FOXC1 was also decreased as the FOXCUT expression was downregulated by siRNA.

siRNA primer Forward Reverse
FOXC1 5'- GGCGAGCAGAGCTACTACC -3' 5'- TGCGAGTACACGCTCATGG -3'[1]
FOXCUT1 5'- GTCGCACCGATGACTAACG -3' 5'- GCCCTGAAAGCCGAACTG -3'[1]


Labs working on this lncRNA

  • Key Laboratory of Oncology, Cancer Center, Division of Internal Medicine, Chinese PLA General Hospital & Chinese PLA Medical School, Beijing, China [1]

References

  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 Pan F, Yao J, Chen Y, Zhou C, Geng P, Mao H, et al. A novel long non-coding RNA FOXCUT and mRNA FOXC1 pair promote progression and predict poor prognosis in esophageal squamous cell carcinoma[J]. International journal of clinical and experimental pathology. 2014,7(6):2838-49.


Basic Information

Transcript ID

NONHSAT106529

Source

NONCODE4.0

Same with

,

Classification

antisense,sense

Length

6813 nt

Genomic location

chr6-:1603265..1642995

Exon number

5

Exons

1603265..1608466,1610339..1610832,1612000..1612105,1630113..1630326,1642199..1642995

Genome context

Sequence
000001 CCAGCACAGC TGCCCACCTG TGCTATTCAC AAAGACACAA GAAGCCATCA TGAAGCAGGC TTTATAAAGT CAAAATATTA 000080
000081 CTCCACGTCT GTTATGCATA AGGACTCAGG ACGATGGTCA CCATGGAACC CCGTTCTCCA ACCTAGAGGA CAAAGACCAG 000160
000161 GTTGACCTTC ACCTTAGGGG GAAGGTGGAG ATTTTGAAGG AGAAATTTAT TTTCTCCCTG ACAAAACCAA AATTTTCAGA 000240
000241 CAAATCTGAG CAACAGTTAT AGAACCTTTG GGGTAGGTTT AAAGACGGAA ACTGGCCGGG TGTGGTGGCT CACGCCTGTA 000320
000321 ATCCCAGCAT TTTGGGAGGC CGAGGTGGGC CGATCATTTG AGGTCAGGAG TTTGAGACTA GCCTGACCAA CATGGTGAAA 000400
000401 CCCTGTCTCT ACTAAAGACA CAAAAATATT AGCCGGGCGT GGTGGCACAT TCCTGTAGTC CCAGCTGCTT GGGAACCTGA 000480
000481 GGCAGGAGAA TCTCTTGAAC CTGGGAGGTG GAGGTTGCAG TGAGCCGAGA TCACACCACT GCACTCCAGC CTGGGCGATA 000560
000561 GAGTGAGACT CTATTTTTTT CTTAAAAAAA AAAAAAAAAA AAAAAAAAGA TGGAAACTGC CCAGATTTCA AGAGAATTGA 000640
000641 GGCTTGCTGC GCTCCCCTTA GTTTCTGAAG AGCAGGGTTC CAAGTGAGCG AGGACAGGAT GAAAAGGAGA GTGCTACGCA 000720
000721 GGGCGATCTT TCTGAGCCAG GGGCCAGTAG GAAAGGACAG GGGCATCCTG AAGGAGCAGG TGAAACGAGG GCCTTCTCAT 000800
000801 ATTTTTAAAA TATAAATGAA AAAAGATCCA TTTATATGTA GGTTGCACTA TACATGCCAT TAAGTTCTCC TTTCCTGAAG 000880
000881 TGAACACCTG TAACTTTTTT TACCACCCTA AGCTTTATTG ACAAGTAGGC ATATAATGAA GACCACGTTC TCATTTACTT 000960
000961 TCCACGAAAG CTCTACTGTA CTAGCCGGAC TTTGTCGCTG GTTTCTGGGG CCAGGTACCA CGAGGTGAGG CGGCCTTGGT 001040
001041 GGGCCGCAGG GTGGTGGCCG GCCTCCTGGC CTCCCCCGCC GCCGCCGCCG CCGCCGCCGT GACTCAGGGA CGACGAGGCA 001120
001121 GGGTGCGAGT ACACGCTCAT GGGGGCCGGC ATGGCGGTGT AGCCGCCCCC GGCCGCCGCG GCCGCCGCGC GGTAGTAGCT 001200
001201 CTGCTCGCCG CCGAGGTAGG GCACCACTCC CAGGGAGTTG GGGCTGGACA CGGAGTAGCG CGCCTGCATG GCCCCCGCTC 001280
001281 GCCGCCGCCC CGCGCCGCCC GCCGCCCCCC ACCCTCGCTC GGGCCGGGCC GCGCCGCGCC GGCCGCCGAG TCCGAGTCCG 001360
001361 GGCCCGGCCG AGCTGGTGCC GGCCCGCTGC GCTGTGCGTC CGGCTGCGCT GCCGCCTCTC CCGGCGCTCG CTGGGGCTGG 001440
001441 CTCCTCCGGC GCCTCGGGCT ACCTCGGGGC CCGCGCGGCC GCGAGGCGGG GTCGCTGCGA GGGGAGAAGG CCGGGCCCGG 001520
001521 CCGCGGCAGA CCGCCTTGCA GGAACTCGCG GCGCAGCTTC CAGGCGCAAA CGGGGGAAAG CAGACAAAAA GAAAGAACAA 001600
001601 GCAGGCGCCC TCTTTGGAGG AGGGAGGGTT GCCCCGAGGT TGCTCTGAAT CCCGGGGCAG CTGCCTCCTG GCCTGCTGTG 001680
001681 CGCCGGGGTC TCTGGAGACT CCTTTTCCAG GTGGTTTGCG GGCCAAGTCA CTGGTGGGTT GGAGAAGCAC CAACAGGAGG 001760
001761 CTCAGCACTT GCTGGTTGCC AAGGACACTA GACAGGGGCG AGGGTGGTGG TGAAGCCCCA GGACCTGAAC ACTTAATTCC 001840
001841 TGTTCAGCCC CCAGCCCGGC ACCCTGAAGG TCTTATCAGC CCGCCTGGTC GAGGCTTTAA GGAGTGCTGT GGCTTCAGCC 001920
001921 TGGAGGAGAT TTAAGTGGTC TCCCTGAACA CCTCAGCAAG TGGTGAGTTC GGTCTTGAAG CTGCCTTTTA CACTGCTAGC 002000
002001 GGTGCGCGGA GATGAACGCA GCGATTACGG ATGCTTTGTT TTCCGAATGC GGGAAACGCC TTCGGCCCCG AGTTTTGCAA 002080
002081 CAGGCAATGG TGCCCCGCTG CCCCCTCCCC CACCAGCCTG TCGCCTCCTG CTCTTCCCTG CCTCCTCCCT CCATCGGCCC 002160
002161 AGTGAAGTGT AAACAGCTTG TTATGTAAAT TGCAAATCGA CCTGCAGCGG TGTTCTCAGC TCTCCGTTTT GGGTATAAAA 002240
002241 GTCGCCGTTG TGAAATTAGT GTCTGGCGTG CGAGAAAAAA TGGAGGGACG TAGTTTTATC AAGATCAACT TTCCACTGGT 002320
002321 TTAGCTCTGG ATATTCGCCA GGAAAAGATA TTTGCATTTG TGTTTTATAA ACTTACTCGG AAGCAAGCCT CCAGTAAGCG 002400
002401 GCTTGATTGT ATTTCAAGCA CTTTTCTTAT TTCATTTTTG TTGTTAGTGG TGTTATTTGA ACATTAAGAC GCAGGCATGA 002480
002481 AGTCTTTTGG GGAACAGGTT AAAGCTTTTA TTTTCAGGTT ACAGTTTTTG ATGCCCCTTT CTGCTACTCC ACGGGGTACT 002560
002561 TCAATCATCC GCTTCCGCAC ATCTCTTGAC TCATTTGGCA GAAGAGCCCC CACGGGAACC CTTCGGCTTC TTTTCTGACA 002640
002641 CCTCACGTAC TTGCAGCCTG AAGGCCCCGC AGGCGACAGC GGTAATGGAT GTTTGGTGGA ACCCTCCCTG GGCCCACACT 002720
002721 CCGCCCCTCC CCAGCAGGCC GGGCAACAAT TCCCAGGGCC CACCGAGGGG TGCTTAGCTC GGAGGAGGGG GAGTGACGTC 002800
002801 ACAGCGATGT TCAAAACAAG GCCTCCCCTG GCCCCACCAT AGAAAAGCAC CAGGAAGGGG AATGTGGCGA GCACTCCAGG 002880
002881 AAATGCTCGG ATTGGGGACC AGGTGACACT GTAGGAATGT GTGTGCTGGG GGATGGGATG GTGTCCTAAA TATGGGTCAC 002960
002961 CAGGAGCCAG AAGGAGCTCT CTTTTTTCTT TTTCTTTTTC AAGTAAAGCA GAGGAGGTGG AGATTGGGAT GGGGGCAGTC 003040
003041 CGGAAAAATC ACTCCCTAGG GGTGTGAGCT TAGCTCGTGT TGTGCGGATT GTCCCCGTCA CAGCCCAATC ACCTCTGTGG 003120
003121 TGTGCCTAGA CGCCCTCTCC CTTACCTCCC CGCTTTCTGG CTTCTCCATC CTCTGGGCTC TGGGTTCAGC CCTGAAAGCC 003200
003201 GAACTGTGGG CTGCAGTGGG GAGGCGAGGG CAGGTAGAAA CCAGCTTCAG GGGGGGCTCC ACCTGGCCCA GGAGCTGGGG 003280
003281 GACAACAGAA AAGGCAGGCT TAGGGCATGA GGGAAGGCGC TTCTCCTGCT GCACTGGGGC AGTGATTCCT GGGGGCTCTG 003360
003361 CACACACAGG AGGGAGGCTG CAAGTCCACA GCTGCTTTAG CATCTTTCCC TTTGCTGGGG CAGACAGAGT GGAAGATTAA 003440
003441 GGCAATTAAC CCCAGAGGGC CACTAGAAAA CTGTCCACTA GGCTGCCATC ACAGACCACT GGAGCAAGGT CCGCTTGGGG 003520
003521 ATGTCTTTGA GCTTTTTAGA TTACTTAGAT AATTGTCTTA GTTCTCCATT CGGCCTCCTT TGCTTAGACC AGAATCCCAG 003600
003601 GGGTAGGGGA GGATATCCTT GCATCAATGC CCGGCATTCG TTTTCAAACC ACCAGGCCGG CAGGCAACGT TAGTCATCGG 003680
003681 TGCGACTTTT CAGCGGAGGA AGGAGTGGGG ACCGAACATC TGGGTGGCCG CGACCTTGGG CAGATACTCC TTAGCTGGGG 003760
003761 GATTTTCAAG TAGAGGATTT GTCAGCACAG TCCCTCCAAT TCAGCCCCGT CCTTAGTAGA AAAATTTCTA CAATAAACGA 003840
003841 AAAGAGCGTT TGGTTTTCGA TTGTTTTAAA GACAAAGTGA TCCATATTGC CTGTCTACAT GGTTGGATTA ATCCGATAGT 003920
003921 TGCCCTCCTG GGGGCAGACC TCCACGGGAA GTTTGTGTGA TGGGATAATT TAATGTCATC TAAGTCCCCT GGAGGGGCGG 004000
004001 TTCCCCTAAC TACTCACCCA GGAGAAAGCC AGCCAACACC TACCTGATCG TTCCCGCCTC GGGATGGCCC ACCTATCGCC 004080
004081 CCTTGGCAGG AAAGCCCCCG CCTCGAAGGG CGTTTCGGGG GCTCAGAGCC GAGCTAAGCT GCAAGAGGGG GCCATGGGGA 004160
004161 ATGCGGGAAG TGAATCTTTA ACTTTGGTGC CCGGCTTCAA AAGACTCAGG GCTTCTTGTG TTCAGGCAGA GGTAAATGGA 004240
004241 GATTCAAACT GTCGTCTTGC ATTAACAATC CGGAATAAAA ATAAAATTCG TAAAGGGATA GATGATCGGA AAGAACAAAT 004320
004321 GGTGCATGTG TGCGCGAACG AGCCCCAGTT TCTCTCCATC CAGGTCCCCA GCGGACTCAG AGCGGCCGCC GCACTCCACG 004400
004401 GCCTGGGAGG ACAGAGGCCC CGCAGCCTCC CAACCTCGGC TCATGTGGGG GGCGCGCCGC GCAGGGTGGG CGAGTCCCCA 004480
004481 GGCCCCAGAG TCTGCCGGAG CCAGGGTGCG CGGTGCGGCG GGAGCCGGCC GTCGGAGGAC TGCAGGGCGA AAGCGCCTTC 004560
004561 CTGGGGCTGG AGCAGAAGGC GTGTGCCCCT GCACGGACGC GCCTTGGCTG TGGGTGTGGG AAGAAAGGCT TTGCCCCGTG 004640
004641 AGACAGACCC ACAGACAGCC CCGGAGCCGC CGGCGGGGTG AGGTGGGCTG CAACCTTGCA GGTGGCTGGC TGTTCCCAGG 004720
004721 TCTCCGGCCC GGCGCCGCAG CGGACCCAGG CGCCGGGGCC GCAGCCAGCC TTCCTTCCGA GTGCTCCCTT CGCGGAACCC 004800
004801 TGCGCCCTGG GACCTTCCTT CCGACGTCCC TCACCCCGGC CGGGGAGTGG CACCAACGCG GACGCACCGC CGGGCCTCCT 004880
004881 GCGGGTAAGG CGCGGTCGGC CCCCAGCTCT GAGCCTTCTG GGCAGGAGCC CCGGGGGCCT GGGCCGGGGC CGGTGTTTGC 004960
004961 ACCTCTCAGG ACAGGGACAA GGCCGACACC CGGCTCGGTG CAGCCGGCCT CCCCCGAGGA CCTGAGGGCC GACGCCTCCG 005040
005041 GGAACCGCTG GTCCTCGCGA GTGGGTCGGC GCCTGGCAGC GCGCGCCGGT GACCTGGTGG TCCGTCTGCT CCCAGGCCGC 005120
005121 CCCTCACAGG CTTCCCGCCG CTTCCCCGCG AGCGTCAGCA GAAAAAGGGA CGATGTGGAA GCCCGGAGGC CCCTTGGCCG 005200
005201 ACCCAGGCTG GGGCTCTCAG GCTGGGGGCA CCTCACCCCG GCAGGTCCCG CGCCTCGGGA ACCCGGGGCC AGGCAGCCGT 005280
005281 CCTGGGCGCC CGCACCGCGC ACTGCGCGTG CTACGAGCGC CCCCTGCCGT CGGAGGCGTT GTCTCCGCGG CGCCTCTGCC 005360
005361 CGCGCCGGGC TCCAAGGGCC GGCTCCGCCT GTCCCCGCAC AGCGTCCCCT GGGAACCGGG TCTCCAGAGA AGGAGGCCTG 005440
005441 GGGAAGACCG CGCCGCCCGC GTGGGACCCC GCAGGGCCTG GCACCTGGTT TTCTAGGCTG CAACTCTCAT CCCTCAGGGT 005520
005521 CCGGGCGGGA ACAGCCCCAT CGGGGAGACC CTCTCAGACT TCCAGGCACA GACCACGGAC GCTTTTGTTC CTGGAGTGGA 005600
005601 GGGAGGTGAC CCGAGACTGG GGCTTTCAGC CACCGCTACG CATTCCTTCC AGGCGGCCCT TTTAATTGAC GTACACGTTA 005680
005681 CAGAAAAAGC AAGGCCGCTC CATCCAGTGA ATTACATTGT GGGAGATGCC AAGGAATGTA TTTACTGGCA GCCAGGTTTG 005760
005761 CCAATAAAAG TTGCAAATAA AGACTGCTGG TTTCCAGGAA AATGTACTTC TGTTTTTTAA ACACTCCTTA GTCTTAATTA 005840
005841 CCAAAAACTG AGCCTCCAAA GAACCGGTTT CGAGAACAGG ACCAGTGAGT GGCGGTGCTG GCGAGGCCTC ACACCCCCAC 005920
005921 GTGCAATCAC ACACCCCGAT GTCGCCTATG GGAACAAGGA CCATGCACAC CTATGGCTTT GCCCACAGAG AGGCTCGCCC 006000
006001 GTATTTACAT ACGCAGCAGA CACAGACACA GGCGAAACGT TGGCACACAG AGAGGTATGC GCTCGGATTA GGGCTGTTTA 006080
006081 GTTTGGAAGT GAAGAAATAA GAAAAGACAA ACTATGGCAA ACAGGCGAAT TTCCACAGAA ATAAATGTCT GCGAGGAAAG 006160
006161 GAGGCACTTG CTCTGTAGTG TTTAGTTATG GTCGCCCTGG TAGTTCTTTT TAGTCCGACC GGGTTGACTA TAAATGAAGG 006240
006241 CAGCAGAGAA ATGCAGAATT TACATTTACT AAAGGTCCGC TTTGGCTTGG GGTCACAAGG ACCCCAGTGG GAATTAGAAA 006320
006321 ATCTCCCCAC TCACTAGATG GAGCAGCACC TCCCCCCACA AAAAAAGGGG TTTGGGGCAG AGTGTGCACG CTAATGAGAG 006400
006401 GCAAATTTAT TCCATGTTTC TCCAATCTTA AACACGGACA CTCATAACCA CAATTATAAA GACTGGTAGG ATGCACAGAA 006480
006481 CACTTAGTAT GCGGTCATCC TGCTGTGTGC TTTAAACACT CCTTTCACCT AATCCTCACA AGGACGCTGA CATGGATATT 006560
006561 ATGATCTACA TCTTACACAT GAGGAAACTG AGCTTAAAGA AAAGAGAGAG CTTTCCCAAG ATTACACAGC CCTCGCAGTT 006640
006641 GCACTCTGCA CAGGCTCACT GGATCTAAGA CGCCACTTAT GATAAGGTAC AGTGCTTATG AGCCACTAAG AGGGGAAAAA 006720
006721 ACTAAATTAT TAAATATCAT CAGTGGTAAA TCTCATCTCC GTTTCAGTTG CTAAAATGAA AAAAAAAATG TGCATTTCAG 006800
006801 ATCGATGATA CGT
[back to top]