Difference between revisions of "SCAANT1"
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===Characteristics=== | ===Characteristics=== | ||
| + | [[File: directly regulates a previously unrecognized ataxin-7 sense promoter by convergent transcription that overlaps the ataxin-7 repeat and the adjacent P2A sense promoter.jpg|right|thumb|400px|'''directly regulates a previously unrecognized ataxin-7 sense promoter by convergent transcription that overlaps the ataxin-7 repeat and the adjacent P2A sense promoter''' <ref name="ref1" />.]] | ||
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SCAANT1, a novel antisense ncRNA transcript, located in 3q14.1 <ref name="ref1" /> | SCAANT1, a novel antisense ncRNA transcript, located in 3q14.1 <ref name="ref1" /> | ||
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===Function=== | ===Function=== | ||
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SCAANT1 directly regulates a previously unrecognized ataxin-7 sense promoter by convergent transcription that overlaps the ataxin-7 repeat and the adjacent P2A sense promoter. <ref name="ref1" />. | SCAANT1 directly regulates a previously unrecognized ataxin-7 sense promoter by convergent transcription that overlaps the ataxin-7 repeat and the adjacent P2A sense promoter. <ref name="ref1" />. | ||
Revision as of 14:45, 29 June 2016
SCAANT1, ATXN7 antisense RNA 1, directly regulates a previously unrecognized ataxin-7 sense promoter by convergent transcription that overlaps the ataxin-7 repeat and the adjacent P2A sense promoter.
Contents
Annotated Information
Name
SCAANT1, SCA7/ATXN7 antisense RNA 1(HGNC nomenclature)
"ATXN7 antisense RNA 1 (non-protein coding)", ATXN7-AS1, "spinocerebellar ataxia-7 antisense noncoding transcript 1"[1]
Characteristics
SCAANT1, a novel antisense ncRNA transcript, located in 3q14.1 [1]
It belongs to the category of "Antisense" in lncRNA classification.
Function
SCAANT1 directly regulates a previously unrecognized ataxin-7 sense promoter by convergent transcription that overlaps the ataxin-7 repeat and the adjacent P2A sense promoter. [1]. .
Regulation
CTCF regulates SCAANT1 expression[1].
Expression
Ataxin-7 sense expression and SCAANT1 expression are inversely correlated in human tissues and SCA7 patients[1]
Sequence
>>gi|22919304|gb|BU569004.1|BU569004 AGENCOURT_10400290 NIH_MGC_82 Homo sapiens cDNA clone IMAGE:6616312 5', mRNA sequence
000081 CTGGGGAACT TGAATTCGTC CAGCAAAGAG AGAACATGAG ATCAGTGTGC GAGGGAATGG AGGAGAGTGA AACAAACCGA 000160
000161 GAGAAGCTTT AACCCGTGTA CATATTTTAG AGGCACCACC CCAAGTTTCT GGAAGTGATT CATTCACCCC AAAAGTAAAA 000240
000241 ATCTGATTCA TTTTTANNAA AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA 000320
000321 AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA AAAAAANNNN NNNNAANNNN NNCCAAAAAA AAAAATTNAA AAAANTTTTN 000400
000401 AAAAACAANN NCNAAAAAAA AAAGNNNAAA AAAAATTTAA NTTAAAACGG TGTCCAAAAA AAATTCCCTA GAAAATCCCC 000480
000481 NNNNCTTCTG GTTTTCCCCC GGGAAATCCC ACCCACGGGA ATTCCTCCCG GGGGGTTCCC CAAAAAAAAT CCCAAGAGGG 000560
000561 GGGCCTAAAG AGGCCTTTTC TTGAACACTT TCCCGGAAGG AATTGCCGGG GGAGCTCCAA AAGGGTTTTG TAACCCCGGG 000640
000641 AAAGCCCCGC CCCCCCGGGA ATTAAGGTGA GAATCCGTTT GAAAATTTCT ATAAAAAAGT TGGAGCGCCC CTGCGGAACG 000720
000721 CCTTCATAAG CCCGGGGGGG GGAAAAGGGG AATCCAAAAG GGTTGTGTCC CCCTCCGCGG AACCCCTTTT GGGAATAAAA 000800
000801 GGGTAAAACC GGGGGACAAA AAAATTTTTC ACAAATGGGG CCCCATTGGG GCCAAAATAG GGGTTAATCT CGCCCA
Labs working on this lncRNA
- Department of Laboratory Medicine, University of Washington, Seattle, WA 98195, USA[1].
