Difference between revisions of "ABHD11-AS1"

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(Created page with " ==Annotated Information== ===Approved Symbol=== ''ABHD11-AS1'' ===Approved Name=== ABHD11 antisense RNA 1 ===Previous Symbols=== WBSCR26, LINC00035 ===Synonyms=== NCRNA000...")
 
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===Ensembl ID===
 
===Ensembl ID===
 
ENSG00000225969
 
ENSG00000225969
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 +
===characteristics===
 +
ABHD11-AS1 RNA is an approximately 473-base-long transcript processed from 4 exonsin human. <ref name="ref1" />
 +
 +
ABHD11-AS1 and its mouse homolog Abhd1os contain 2 small potential ORFs (ORF1, 105 nucleotides and ORF2, 138 nucleotides in mouse), which are conserved across mammals. <ref name="ref1" />
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 +
===Function===
 +
[[File: Effect of the knock down of Abhd11os on the toxicity induced by mHtt.jpg|right|thumb|400px|'''Effect of the knock down of Abhd11os on the toxicity induced by mHtt''' <ref name="ref1" />.]]
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Abhd11os has a neuroprotective effect against mHtt. <ref name="ref1" />
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===Expression===
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Abhd11os levels are markedly reduced in different mouse models of Huntington disease (HD) <ref name="ref1" />
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Abhd11os overexpression produces neuroprotection against an N-terminal fragment of mutant huntingtin, whereas Abhd11os knockdown is protoxic.<ref name="ref1" />
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Compared with adjacent non-tumor tissues, the expression level of ABHD11-AS1 in gastric cancer tissues was significantly increased. <ref name="ref2" />
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 +
{| class='wikitable' style="text-align:center"
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|-
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! | Primer
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! | Forward primer
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! | Reverse primer
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|-
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| rowspan="1"|RT-PCR
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| | Abhd11os-U GGATTGCCTCGGACCTG
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| | Abhd11os-L GCACCCGCTCTCGAAC <ref name="ref1" />
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|-
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| rowspan="2"| Knockdown
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| | Abhd11os-directedsmall hairpin RNA (shRNA)
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| | 5'GGGATGAAGCCATTGCTAA 3' <ref name="ref1" />
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|-
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| | Luciferase-targeted shRNA
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| | 5'CGTACGCGGAATACTTCGA 3' <ref name="ref1" />
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|}
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===Disease===
 +
ABHD11-AS1 might be a potential biomarker for diagnosis of gastric cancer. <ref name="ref2" />
  
 
===pubmed IDs===
 
===pubmed IDs===
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===Sequence===
 
===Sequence===
 
<dnaseq>CCCTAAGTCCCAGCCCTTGAGGGTCCATGAGACTGGGGCAGCAGCAGGGGCAGGTACAGAGCACCTCAGCCGCCTCTCCACCTGACAGCAACATCAAAGCCGAGGCCAAGGCGGGAGGGCCCAGAGTGAGACACCTCTTCCAGACAAGACTTGGTCGCTGCCTCCTCCTCTGTCACCCTGCGACACAGCCCAGAGTACCAGGCGGCTGGAGCACTGGGGGACACCCGGACAGAACCCTCCCTGGACCAAGTCCTCCAGGAACGGGATGAAGCCATTGCCAAGAAGCAGGCGGTGGAGGCGGAGCTGCAGAGATGCAAAGCCAGGCTACACGCCATGGAGGCCCAGCTGCTGGAGGTCCTGGAGGAGAAACTGAGGCTGAGGCGGGAGCTGGAGGCCTGGGAGGAGGACGTGCAGCAGCTGGTGTGGCAGCAGGTCCAGAATCAGCTGCAGAGAGAGGCCAAGGGTACTCGGGG</dnaseq>
 
<dnaseq>CCCTAAGTCCCAGCCCTTGAGGGTCCATGAGACTGGGGCAGCAGCAGGGGCAGGTACAGAGCACCTCAGCCGCCTCTCCACCTGACAGCAACATCAAAGCCGAGGCCAAGGCGGGAGGGCCCAGAGTGAGACACCTCTTCCAGACAAGACTTGGTCGCTGCCTCCTCCTCTGTCACCCTGCGACACAGCCCAGAGTACCAGGCGGCTGGAGCACTGGGGGACACCCGGACAGAACCCTCCCTGGACCAAGTCCTCCAGGAACGGGATGAAGCCATTGCCAAGAAGCAGGCGGTGGAGGCGGAGCTGCAGAGATGCAAAGCCAGGCTACACGCCATGGAGGCCCAGCTGCTGGAGGTCCTGGAGGAGAAACTGAGGCTGAGGCGGGAGCTGGAGGCCTGGGAGGAGGACGTGCAGCAGCTGGTGTGGCAGCAGGTCCAGAATCAGCTGCAGAGAGAGGCCAAGGGTACTCGGGG</dnaseq>
 +
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==Labs working on this lncRNA==
 +
* CEA, DSV, I²BM, Molecular Imaging Research Center (MIRCen), Fontenay-aux-Roses, France<ref name="ref1" />.
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* Department of Biochemistry and Molecular Biology, Zhejiang Provincial Key Laboratory of Pathophysiology, Ningbo University School of Medicine, 818 Fenghua Road, Ningbo, 315211, China.<ref name="ref2" />.
 +
 +
==References==
 +
<references>
 +
<ref name="ref1"> Francelle L, Galvan L, Gaillard MC, Petit F, Bernay B, Guillermier M, et al. Striatal long noncoding RNA Abhd11os is neuroprotective against an N-terminal fragment of mutant huntingtin in vivo[J]. Neurobiology of aging. 2015,36(3):1601 e7-16.</ref>(1)
 +
<ref name="ref2"> Lin X, Yang M, Xia T, Guo J. Increased expression of long noncoding RNA ABHD11-AS1 in gastric cancer and its clinical significance[J]. Medical oncology. 2014,31(7):42.</ref>(2)
 +
</references>

Revision as of 06:40, 28 June 2016

Annotated Information

Approved Symbol

ABHD11-AS1

Approved Name

ABHD11 antisense RNA 1

Previous Symbols

WBSCR26, LINC00035

Synonyms

NCRNA00035

Chromosome

7q11.23

RefSeq ID

NR_026690

OMIM ID

612545

Ensembl ID

ENSG00000225969

characteristics

ABHD11-AS1 RNA is an approximately 473-base-long transcript processed from 4 exonsin human. [1]

ABHD11-AS1 and its mouse homolog Abhd1os contain 2 small potential ORFs (ORF1, 105 nucleotides and ORF2, 138 nucleotides in mouse), which are conserved across mammals. [1]

Function

Effect of the knock down of Abhd11os on the toxicity induced by mHtt [1].

Abhd11os has a neuroprotective effect against mHtt. [1]

Expression

Abhd11os levels are markedly reduced in different mouse models of Huntington disease (HD) [1]

Abhd11os overexpression produces neuroprotection against an N-terminal fragment of mutant huntingtin, whereas Abhd11os knockdown is protoxic.[1]

Compared with adjacent non-tumor tissues, the expression level of ABHD11-AS1 in gastric cancer tissues was significantly increased. [2]

Primer Forward primer Reverse primer
RT-PCR Abhd11os-U GGATTGCCTCGGACCTG Abhd11os-L GCACCCGCTCTCGAAC [1]
Knockdown Abhd11os-directedsmall hairpin RNA (shRNA) 5'GGGATGAAGCCATTGCTAA 3' [1]
Luciferase-targeted shRNA 5'CGTACGCGGAATACTTCGA 3' [1]

Disease

ABHD11-AS1 might be a potential biomarker for diagnosis of gastric cancer. [2]

pubmed IDs

24984296, 25619660

Sequence

000001 CCCTAAGTCC CAGCCCTTGA GGGTCCATGA GACTGGGGCA GCAGCAGGGG CAGGTACAGA GCACCTCAGC CGCCTCTCCA 000080
000081 CCTGACAGCA ACATCAAAGC CGAGGCCAAG GCGGGAGGGC CCAGAGTGAG ACACCTCTTC CAGACAAGAC TTGGTCGCTG 000160
000161 CCTCCTCCTC TGTCACCCTG CGACACAGCC CAGAGTACCA GGCGGCTGGA GCACTGGGGG ACACCCGGAC AGAACCCTCC 000240
000241 CTGGACCAAG TCCTCCAGGA ACGGGATGAA GCCATTGCCA AGAAGCAGGC GGTGGAGGCG GAGCTGCAGA GATGCAAAGC 000320
000321 CAGGCTACAC GCCATGGAGG CCCAGCTGCT GGAGGTCCTG GAGGAGAAAC TGAGGCTGAG GCGGGAGCTG GAGGCCTGGG 000400
000401 AGGAGGACGT GCAGCAGCTG GTGTGGCAGC AGGTCCAGAA TCAGCTGCAG AGAGAGGCCA AGGGTACTCG GGG

Labs working on this lncRNA

  • CEA, DSV, I²BM, Molecular Imaging Research Center (MIRCen), Fontenay-aux-Roses, France[1].
  • Department of Biochemistry and Molecular Biology, Zhejiang Provincial Key Laboratory of Pathophysiology, Ningbo University School of Medicine, 818 Fenghua Road, Ningbo, 315211, China.[2].

References

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 1.9 Francelle L, Galvan L, Gaillard MC, Petit F, Bernay B, Guillermier M, et al. Striatal long noncoding RNA Abhd11os is neuroprotective against an N-terminal fragment of mutant huntingtin in vivo[J]. Neurobiology of aging. 2015,36(3):1601 e7-16.
  2. ↑ 2.0 2.1 2.2 Lin X, Yang M, Xia T, Guo J. Increased expression of long noncoding RNA ABHD11-AS1 in gastric cancer and its clinical significance[J]. Medical oncology. 2014,31(7):42.
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