Difference between revisions of "FOXC2-AS1"
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==Annotated Information== | ==Annotated Information== | ||
| − | === | + | ===Name=== |
| − | FOXC2-AS1 | + | Approved Symbol: FOXC2-AS1 |
| − | + | ||
| − | FOXC2 antisense RNA 1 | + | Approved Name: FOXC2 antisense RNA 1 |
| − | + | ||
| − | + | Synonyms: ODRUL | |
| − | + | ||
| − | + | RefSeq ID: NR_125795 | |
| + | |||
| + | Ensembl ID: ENSG00000260944 | ||
| + | |||
| + | LncBook transcript ID: HSALNT0288979 | ||
===Chromosome=== | ===Chromosome=== | ||
16q24.1 | 16q24.1 | ||
| − | === | + | |
| − | + | ===Characteristics=== | |
| − | === | + | - |
| − | + | ||
| − | === | + | ===Function=== |
| − | + | [[File:FOXC2-AS1-exp.png|right|thumb|300px|FOXC2-AS1 was significantly upregulated in breast cancer (BC) tissues and cell lines.<ref name="ref1" />.]] | |
| + | |||
| + | [[File:FOXC2-AS1-fun.png|right|thumb|400px|Silenced FOXC2-AS1 caused cell cycle arrest and induced apoptosis<ref name="ref1" />.]] | ||
| + | * Loss of function revealed that silenced FOXC2-AS1 significantly suppressed the proliferation ability, and flow cytometric analysis illustrated the influence of FOXC2-AS1 on cell cycle and apoptosis rate. Cyclin D1, cyclin D2, and cyclin D3 were all partly positively modulated by FOXC2-AS1 in breast cancer (BC).<ref name="ref1" />. | ||
| + | |||
| + | ===Regulation=== | ||
| + | - | ||
| + | |||
| + | ===Diseases=== | ||
| + | Breast cancer<ref name="ref1" /> | ||
| + | |||
| + | ===Expression=== | ||
| + | FOXC2-AS1 was significantly increased in BC tissues and cell lines, and Kaplan–Meier survival analysis indicated that a high level of FOXC2-AS1 was associated with poor prognosis of BC patients<ref name="ref1" />. | ||
| + | |||
| + | {| class='wikitable' style="text-align:center" | ||
| + | |- | ||
| + | ! | Experiment | ||
| + | ! | Forward primer | ||
| + | ! | Reverse primer | ||
| + | |- | ||
| + | | rowspan="1"|Quantitative real-time PCR | ||
| + | | | 5'-TTCATCGGCTGCGTATTCG- 3' | ||
| + | | | 5'-TTGCCTTCTAGTCGCCTCC- 3'<ref name="ref1" /> | ||
| + | |} | ||
| + | |||
| + | ===Evolution=== | ||
| + | - | ||
===pubmed IDs=== | ===pubmed IDs=== | ||
| − | 26408180 | + | 26408180, 29562954 |
===Sequence=== | ===Sequence=== | ||
>gi|672890592|ref|NR_125795.1| Homo sapiens FOXC2 antisense RNA 1 (FOXC2-AS1), long non-coding RNA | >gi|672890592|ref|NR_125795.1| Homo sapiens FOXC2 antisense RNA 1 (FOXC2-AS1), long non-coding RNA | ||
<dnaseq>CTTGCCGGGCTTCTTGTCGTCGCGGGGCACCTTGACGAAGCACTCGTTGAGCGAGAGGTTGTGGCGGATGCTGTTCTGCCAGCCCTGCTTGTTCTCCCGGTAGAAGGGGAAGCGGTCCATGATGAACTGGTAGATGCCGTTCAAGGTTTCCTTGCACCCTTCCTGGCTGTTCATCGGCTGCGTATTCGATTCTCAGCAAAAGGATGTTGAGACAACCCACCAGGCCTCTTCGCTTCGGCCTCTTCGCTTCGGGGAGGCGACTAGAAGGCAATGGGGCGTGCCACTTATTTCCAATAAAAGAACAGAAGACGAAAATGTA</dnaseq> | <dnaseq>CTTGCCGGGCTTCTTGTCGTCGCGGGGCACCTTGACGAAGCACTCGTTGAGCGAGAGGTTGTGGCGGATGCTGTTCTGCCAGCCCTGCTTGTTCTCCCGGTAGAAGGGGAAGCGGTCCATGATGAACTGGTAGATGCCGTTCAAGGTTTCCTTGCACCCTTCCTGGCTGTTCATCGGCTGCGTATTCGATTCTCAGCAAAAGGATGTTGAGACAACCCACCAGGCCTCTTCGCTTCGGCCTCTTCGCTTCGGGGAGGCGACTAGAAGGCAATGGGGCGTGCCACTTATTTCCAATAAAAGAACAGAAGACGAAAATGTA</dnaseq> | ||
| + | ==Labs working on this lncRNA== | ||
| + | * Department of Breast Surgery, the Affiliated Hospital of Guizhou Medical University, Guizhou, P.R. China | ||
| + | ==References== | ||
| + | <references> | ||
| + | <ref name="ref1"> | ||
| + | Yang H, Chen T, Xu S, Zhang S, Zhang M. Long Noncoding RNA FOXC2-AS1 Predicts Poor Survival in Breast Cancer Patients and Promotes Cell Proliferation. Oncol Res. 2019 Feb 5;27(2):219-226. | ||
| + | </ref>(1) | ||
| + | </references> | ||
Latest revision as of 07:37, 14 August 2019
Contents
Annotated Information
Name
Approved Symbol: FOXC2-AS1
Approved Name: FOXC2 antisense RNA 1
Synonyms: ODRUL
RefSeq ID: NR_125795
Ensembl ID: ENSG00000260944
LncBook transcript ID: HSALNT0288979
Chromosome
16q24.1
Characteristics
-
Function
FOXC2-AS1 was significantly upregulated in breast cancer (BC) tissues and cell lines.[1].
Silenced FOXC2-AS1 caused cell cycle arrest and induced apoptosis[1].
- Loss of function revealed that silenced FOXC2-AS1 significantly suppressed the proliferation ability, and flow cytometric analysis illustrated the influence of FOXC2-AS1 on cell cycle and apoptosis rate. Cyclin D1, cyclin D2, and cyclin D3 were all partly positively modulated by FOXC2-AS1 in breast cancer (BC).[1].
Regulation
-
Diseases
Breast cancer[1]
Expression
FOXC2-AS1 was significantly increased in BC tissues and cell lines, and Kaplan–Meier survival analysis indicated that a high level of FOXC2-AS1 was associated with poor prognosis of BC patients[1].
| Experiment | Forward primer | Reverse primer |
|---|---|---|
| Quantitative real-time PCR | 5'-TTCATCGGCTGCGTATTCG- 3' | 5'-TTGCCTTCTAGTCGCCTCC- 3'[1] |
Evolution
-
pubmed IDs
26408180, 29562954
Sequence
>gi|672890592|ref|NR_125795.1| Homo sapiens FOXC2 antisense RNA 1 (FOXC2-AS1), long non-coding RNA
000001 CTTGCCGGGC TTCTTGTCGT CGCGGGGCAC CTTGACGAAG CACTCGTTGA GCGAGAGGTT GTGGCGGATG CTGTTCTGCC 000080
000081 AGCCCTGCTT GTTCTCCCGG TAGAAGGGGA AGCGGTCCAT GATGAACTGG TAGATGCCGT TCAAGGTTTC CTTGCACCCT 000160
000161 TCCTGGCTGT TCATCGGCTG CGTATTCGAT TCTCAGCAAA AGGATGTTGA GACAACCCAC CAGGCCTCTT CGCTTCGGCC 000240
000241 TCTTCGCTTC GGGGAGGCGA CTAGAAGGCA ATGGGGCGTG CCACTTATTT CCAATAAAAG AACAGAAGAC GAAAATGTA
000081 AGCCCTGCTT GTTCTCCCGG TAGAAGGGGA AGCGGTCCAT GATGAACTGG TAGATGCCGT TCAAGGTTTC CTTGCACCCT 000160
000161 TCCTGGCTGT TCATCGGCTG CGTATTCGAT TCTCAGCAAA AGGATGTTGA GACAACCCAC CAGGCCTCTT CGCTTCGGCC 000240
000241 TCTTCGCTTC GGGGAGGCGA CTAGAAGGCA ATGGGGCGTG CCACTTATTT CCAATAAAAG AACAGAAGAC GAAAATGTA
Labs working on this lncRNA
- Department of Breast Surgery, the Affiliated Hospital of Guizhou Medical University, Guizhou, P.R. China
