Difference between revisions of "DGCR9"

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==Annotated Information==
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===Name===
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Approved Symbol: DGCR9
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Approved Name: DiGeorge syndrome critical region gene 9 (non-protein coding)
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Synonyms: DGS-A, POM121L5P
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Chromosome: 22q11.21
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RefSeq ID: NR_024159
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Ensembl ID: ENSG00000273032
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LncBook transcript ID: HSALNT0275220
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===Characteristics===
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===Function===
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* DGCR9 was positively associated with lymph node invasion and tumor-node-metastasis (TNM) stage in gastric cancer patients. By in vitro functional analysis, knockdown of DGCR9 in gastric cancer cells suppressed cellular proliferation, migration, and glucose uptake. In contrast, overexpression of DGCR9 increased each of these cancer cell characteristics<ref name="ref1" />.
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===Regulation===
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===Diseases===
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Gastric cancer<ref name="ref1" />.
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===Expression===
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DGCR9 was significantly upregulated in gastric cancer tissues and cell lines<ref name="ref1" />.
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{| class='wikitable' style="text-align:center"
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|-
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! | Experiment
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! | Forward primer
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! | Reverse primer
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|-
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| rowspan="1"|Quantitative real-time PCR
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| |  5'-TAGCATGGCCAGGTATGCAC- 3'
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| |  5'-TGCGAATCCCAAAGCTGTCA- 3'<ref name="ref1" />
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|}
  
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===Evolution===
  
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==Annotated Information==
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===Approved Symbol===
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==Labs working on this lncRNA==
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DGCR9
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* Department of Biochemistry and Molecular Biology, Zhejiang Key Laboratory of Pathophysiology, Medical School of Ningbo University, Ningbo, People’s Republic of China.
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===Approved Name===
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==References==
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DiGeorge syndrome critical region gene 9 (non-protein coding)
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<references>
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===Previous Symbols===
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<ref name="ref1">
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_
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Ni C, Yang P, Guo J, Ye M. Role of DiGeorge syndrome critical region gene 9, a long noncoding RNA, in gastric cancer. Onco Targets Ther. 2018 Apr 19;11:2259-2267.  
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===Synonyms===
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</ref>(1)
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DGS-A, POM121L5P
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</references>
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===Chromosome===
 
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22q11.21
 
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===RefSeq ID===
 
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NR_024159
 
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===OMIM ID===
 
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_
 
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===Ensembl ID===
 
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ENSG00000273032
 
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===pubmed IDs===
 
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8776594
 
 
===Sequence===
 
===Sequence===
 
>gi|205830460|ref|NR_024159.1| Homo sapiens DiGeorge syndrome critical region gene 9 (non-protein coding) (DGCR9), long non-coding RNA
 
>gi|205830460|ref|NR_024159.1| Homo sapiens DiGeorge syndrome critical region gene 9 (non-protein coding) (DGCR9), long non-coding RNA
 
<dnaseq>GTAAAACTCATATGAAACCAAAAAAGAGCTCAAAGAGCCAAAGTCATCCTCAGCAAAAACAACAAAACTAGAAGCACCCCATTTCACTGCAAATTAGAATGACAAAATTTTTGACAAGTGCATGGTAACCAAAACAGCATGGTCCTAGCATAAAACTAGACACATAGATCAATGGGACGGATGACAGAGCCCAGAAAGACAGCCACATAGTCTTGGGGCTTGTGTCTCTCCTGCTGTGCATCCATGCTGGGTGCTTTACATACAACAGGCAGACAAGAAGTCCCTGTTGCAAGTGAGGACAAAGTGTGGGAAGGCCGTGAGGGTCTGCAGTCCCAGATGGCCTTGGCCTCACCCCGCAGTGCGCTTTTGCACCAGAGTGCCACCTTCTTCTCCAGGTCCAGGTCTTCAGCAGTGACCCCAGACCCCAGCTGTAAGGGAGGTGGCAGCATCAGAGGCTCCCCTTGCCTGAGTGGCAGCAGAGGAAACTTGCATCTATGGGGCCTAGAGGCCTGGGATGTGGGGGAGCCATTCCTGGGGGCAAGTGTCTGCCCTGGTGCTGCATCTGCTGCCTTTTCACACTGGGTGAGACCCCAAGAGACAGCCTGAGGCCGGTCCTCACTCACTGTCTTTGAGGACCTGAGGGGCAGCTGACAGTGGGATGAGGCTGGCCCCCTCCTCTTTGGTGACAGGAAGCCTCCCATGGAACTGTAGGAGCTCACGATGGCATTTTGTTTGGTGCACGAACTCATCCAGGAGGTCTGGGATCTCTGGTTTTATCCGACTTCTGACCTCTGGGCATGGAGGTCTCTCTGCAGAGGCCCAGGCCTGGGCACGAAGGGAGAGAGGCCTCCATTGTCCCACAGGGGCCTAAATGCAGACTGTGCATCCCCGGTGCCCTCAGGAACCCTTCTCTGATCATCAGGATTCTCTTGGACTCTGGGGTCCTTGTCCTGCTCAGGCATCCCTGCCCCCCTCTTCAGGAGGGCCCTCAACACGATCTTCTCTGGACAGGAGTCTGGGGCACAACTGGATGTTGTGGGCCCCAAAGGGGTGACTCCCTGCTCCTGGGCCCCACAGAGAGTCCTTGTGCTCAGTGCACTGGCTGAGCTGCAAGACATCCTGGAATTGGGAGCACACAGCACCGGCTTGCTGTGGTACCTGTGCATTCAAATTGAAGGCAGGATCGCCAGCAAGGAACACAGGGCTTGCAGGATCACAGAAAACCCTTGGAGTTGTTTTGACACACCACTGATGCCAAGTGTCTGGGTACTTGTAGGATGGCCCTGCCATTCCATCCAGGGGCAGTGGCAACAGGGAGATTCCACAAACAAAGTGAACTGGGGGATGGGATGAGCAGGCTCCAGGCAACTGAGCCCTACTGGCAGGCCCTTGGCCCCCGGGGCCGGGACAGGGGTGACAGACACAGAGTGCCCAGGTAACCACTCCTGGGAGCAGTGGGGAACCGTCGGATGCTTCAACTCTTGAGAGCTGGGCTCTAAGCATCCGCCTTAGCTGCCAACTTGGCCAAAGGCTATGCGAGCAGTTTCCCGTTGACGGGCAATGCATCTTTCCAACCTGAGCGAGTGGGTGTGTGTGCAAAGATGGTGCGAGTCACGGATCTGCGCAGGAAGGGTGACTTTAAGGGATTAGCATGGCCAGGTATGCACACAAGGCACCTGCTGGCAATGCCTTGGTGGGGAGCGGGCAGTGCACACAAGAGGTACTGGAGGGAGAGGCGCGCGGGAAGAACAGGCGCGCACAATGGCTGCAGATCCACCTGTGGATCGCTGAAGATTCCTGCTGAGGGTTGAGGCTGCTGGGCTGGAGGACTGTATGGTCCATGCATTGTAATGTCCCCTTCTCTCCCTGGCCCGGAGCCCCAAGAGCTATCCGGACTCTCTCCAAGACCTGGTTCTGGCCCAGCAAAGAGGTCTCGGCAGGGGAGCAGGATTCCCGGCCCAGCAGCTGGCTCAGGAGGTGACAGCTTTGGGATTCGCATCTGAGCATCCTCCTACTCTTCTCCTGGGAACTCTGTTGGGGAGGGTTGCTCAGAACAGAAGTGCCTGGGACGCCCAGATCCTGCTGGAGTGGCAGCTGGGGTGATGGCCAGGGCAGGCTGGGAGGGACATACTTTCCATAGGACCCAGTGCTTTCATCTCCGTGCAACTGACCAAGAGAAACCAAACCCAAACTCCTTCCTTTACACAGACCTATTTGAGGGAGGCTGGGTATTGTTTGTGTATTTCAACCTAACAAGATTTTGAGATAGTTGGAATGCAGAAGGAGACAGGAGGACTCAAGTGTCCTGTCTTTTGCAAAAATGTCAAACGTAGCTACTCAGTCTCTTTTTTGTTTTTTTGTTTGTTTTGAAGACTATGGTTATTTTGCAAAATATATATTATTTGAGTTTCTCTAAAAAAAAAAAAAAAAAAAA</dnaseq>
 
<dnaseq>GTAAAACTCATATGAAACCAAAAAAGAGCTCAAAGAGCCAAAGTCATCCTCAGCAAAAACAACAAAACTAGAAGCACCCCATTTCACTGCAAATTAGAATGACAAAATTTTTGACAAGTGCATGGTAACCAAAACAGCATGGTCCTAGCATAAAACTAGACACATAGATCAATGGGACGGATGACAGAGCCCAGAAAGACAGCCACATAGTCTTGGGGCTTGTGTCTCTCCTGCTGTGCATCCATGCTGGGTGCTTTACATACAACAGGCAGACAAGAAGTCCCTGTTGCAAGTGAGGACAAAGTGTGGGAAGGCCGTGAGGGTCTGCAGTCCCAGATGGCCTTGGCCTCACCCCGCAGTGCGCTTTTGCACCAGAGTGCCACCTTCTTCTCCAGGTCCAGGTCTTCAGCAGTGACCCCAGACCCCAGCTGTAAGGGAGGTGGCAGCATCAGAGGCTCCCCTTGCCTGAGTGGCAGCAGAGGAAACTTGCATCTATGGGGCCTAGAGGCCTGGGATGTGGGGGAGCCATTCCTGGGGGCAAGTGTCTGCCCTGGTGCTGCATCTGCTGCCTTTTCACACTGGGTGAGACCCCAAGAGACAGCCTGAGGCCGGTCCTCACTCACTGTCTTTGAGGACCTGAGGGGCAGCTGACAGTGGGATGAGGCTGGCCCCCTCCTCTTTGGTGACAGGAAGCCTCCCATGGAACTGTAGGAGCTCACGATGGCATTTTGTTTGGTGCACGAACTCATCCAGGAGGTCTGGGATCTCTGGTTTTATCCGACTTCTGACCTCTGGGCATGGAGGTCTCTCTGCAGAGGCCCAGGCCTGGGCACGAAGGGAGAGAGGCCTCCATTGTCCCACAGGGGCCTAAATGCAGACTGTGCATCCCCGGTGCCCTCAGGAACCCTTCTCTGATCATCAGGATTCTCTTGGACTCTGGGGTCCTTGTCCTGCTCAGGCATCCCTGCCCCCCTCTTCAGGAGGGCCCTCAACACGATCTTCTCTGGACAGGAGTCTGGGGCACAACTGGATGTTGTGGGCCCCAAAGGGGTGACTCCCTGCTCCTGGGCCCCACAGAGAGTCCTTGTGCTCAGTGCACTGGCTGAGCTGCAAGACATCCTGGAATTGGGAGCACACAGCACCGGCTTGCTGTGGTACCTGTGCATTCAAATTGAAGGCAGGATCGCCAGCAAGGAACACAGGGCTTGCAGGATCACAGAAAACCCTTGGAGTTGTTTTGACACACCACTGATGCCAAGTGTCTGGGTACTTGTAGGATGGCCCTGCCATTCCATCCAGGGGCAGTGGCAACAGGGAGATTCCACAAACAAAGTGAACTGGGGGATGGGATGAGCAGGCTCCAGGCAACTGAGCCCTACTGGCAGGCCCTTGGCCCCCGGGGCCGGGACAGGGGTGACAGACACAGAGTGCCCAGGTAACCACTCCTGGGAGCAGTGGGGAACCGTCGGATGCTTCAACTCTTGAGAGCTGGGCTCTAAGCATCCGCCTTAGCTGCCAACTTGGCCAAAGGCTATGCGAGCAGTTTCCCGTTGACGGGCAATGCATCTTTCCAACCTGAGCGAGTGGGTGTGTGTGCAAAGATGGTGCGAGTCACGGATCTGCGCAGGAAGGGTGACTTTAAGGGATTAGCATGGCCAGGTATGCACACAAGGCACCTGCTGGCAATGCCTTGGTGGGGAGCGGGCAGTGCACACAAGAGGTACTGGAGGGAGAGGCGCGCGGGAAGAACAGGCGCGCACAATGGCTGCAGATCCACCTGTGGATCGCTGAAGATTCCTGCTGAGGGTTGAGGCTGCTGGGCTGGAGGACTGTATGGTCCATGCATTGTAATGTCCCCTTCTCTCCCTGGCCCGGAGCCCCAAGAGCTATCCGGACTCTCTCCAAGACCTGGTTCTGGCCCAGCAAAGAGGTCTCGGCAGGGGAGCAGGATTCCCGGCCCAGCAGCTGGCTCAGGAGGTGACAGCTTTGGGATTCGCATCTGAGCATCCTCCTACTCTTCTCCTGGGAACTCTGTTGGGGAGGGTTGCTCAGAACAGAAGTGCCTGGGACGCCCAGATCCTGCTGGAGTGGCAGCTGGGGTGATGGCCAGGGCAGGCTGGGAGGGACATACTTTCCATAGGACCCAGTGCTTTCATCTCCGTGCAACTGACCAAGAGAAACCAAACCCAAACTCCTTCCTTTACACAGACCTATTTGAGGGAGGCTGGGTATTGTTTGTGTATTTCAACCTAACAAGATTTTGAGATAGTTGGAATGCAGAAGGAGACAGGAGGACTCAAGTGTCCTGTCTTTTGCAAAAATGTCAAACGTAGCTACTCAGTCTCTTTTTTGTTTTTTTGTTTGTTTTGAAGACTATGGTTATTTTGCAAAATATATATTATTTGAGTTTCTCTAAAAAAAAAAAAAAAAAAAA</dnaseq>

Revision as of 07:08, 2 August 2019

Annotated Information

Name

Approved Symbol: DGCR9

Approved Name: DiGeorge syndrome critical region gene 9 (non-protein coding)

Synonyms: DGS-A, POM121L5P

Chromosome: 22q11.21

RefSeq ID: NR_024159

Ensembl ID: ENSG00000273032

LncBook transcript ID: HSALNT0275220

Characteristics

Function

  • DGCR9 was positively associated with lymph node invasion and tumor-node-metastasis (TNM) stage in gastric cancer patients. By in vitro functional analysis, knockdown of DGCR9 in gastric cancer cells suppressed cellular proliferation, migration, and glucose uptake. In contrast, overexpression of DGCR9 increased each of these cancer cell characteristics[1].

Regulation

Diseases

Gastric cancer[1].

Expression

DGCR9 was significantly upregulated in gastric cancer tissues and cell lines[1].

Experiment Forward primer Reverse primer
Quantitative real-time PCR 5'-TAGCATGGCCAGGTATGCAC- 3' 5'-TGCGAATCCCAAAGCTGTCA- 3'[1]

Evolution

Labs working on this lncRNA

  • Department of Biochemistry and Molecular Biology, Zhejiang Key Laboratory of Pathophysiology, Medical School of Ningbo University, Ningbo, People’s Republic of China.

References

  1. ↑ 1.0 1.1 1.2 1.3 Ni C, Yang P, Guo J, Ye M. Role of DiGeorge syndrome critical region gene 9, a long noncoding RNA, in gastric cancer. Onco Targets Ther. 2018 Apr 19;11:2259-2267.

Sequence

>gi|205830460|ref|NR_024159.1| Homo sapiens DiGeorge syndrome critical region gene 9 (non-protein coding) (DGCR9), long non-coding RNA

000001 GTAAAACTCA TATGAAACCA AAAAAGAGCT CAAAGAGCCA AAGTCATCCT CAGCAAAAAC AACAAAACTA GAAGCACCCC 000080
000081 ATTTCACTGC AAATTAGAAT GACAAAATTT TTGACAAGTG CATGGTAACC AAAACAGCAT GGTCCTAGCA TAAAACTAGA 000160
000161 CACATAGATC AATGGGACGG ATGACAGAGC CCAGAAAGAC AGCCACATAG TCTTGGGGCT TGTGTCTCTC CTGCTGTGCA 000240
000241 TCCATGCTGG GTGCTTTACA TACAACAGGC AGACAAGAAG TCCCTGTTGC AAGTGAGGAC AAAGTGTGGG AAGGCCGTGA 000320
000321 GGGTCTGCAG TCCCAGATGG CCTTGGCCTC ACCCCGCAGT GCGCTTTTGC ACCAGAGTGC CACCTTCTTC TCCAGGTCCA 000400
000401 GGTCTTCAGC AGTGACCCCA GACCCCAGCT GTAAGGGAGG TGGCAGCATC AGAGGCTCCC CTTGCCTGAG TGGCAGCAGA 000480
000481 GGAAACTTGC ATCTATGGGG CCTAGAGGCC TGGGATGTGG GGGAGCCATT CCTGGGGGCA AGTGTCTGCC CTGGTGCTGC 000560
000561 ATCTGCTGCC TTTTCACACT GGGTGAGACC CCAAGAGACA GCCTGAGGCC GGTCCTCACT CACTGTCTTT GAGGACCTGA 000640
000641 GGGGCAGCTG ACAGTGGGAT GAGGCTGGCC CCCTCCTCTT TGGTGACAGG AAGCCTCCCA TGGAACTGTA GGAGCTCACG 000720
000721 ATGGCATTTT GTTTGGTGCA CGAACTCATC CAGGAGGTCT GGGATCTCTG GTTTTATCCG ACTTCTGACC TCTGGGCATG 000800
000801 GAGGTCTCTC TGCAGAGGCC CAGGCCTGGG CACGAAGGGA GAGAGGCCTC CATTGTCCCA CAGGGGCCTA AATGCAGACT 000880
000881 GTGCATCCCC GGTGCCCTCA GGAACCCTTC TCTGATCATC AGGATTCTCT TGGACTCTGG GGTCCTTGTC CTGCTCAGGC 000960
000961 ATCCCTGCCC CCCTCTTCAG GAGGGCCCTC AACACGATCT TCTCTGGACA GGAGTCTGGG GCACAACTGG ATGTTGTGGG 001040
001041 CCCCAAAGGG GTGACTCCCT GCTCCTGGGC CCCACAGAGA GTCCTTGTGC TCAGTGCACT GGCTGAGCTG CAAGACATCC 001120
001121 TGGAATTGGG AGCACACAGC ACCGGCTTGC TGTGGTACCT GTGCATTCAA ATTGAAGGCA GGATCGCCAG CAAGGAACAC 001200
001201 AGGGCTTGCA GGATCACAGA AAACCCTTGG AGTTGTTTTG ACACACCACT GATGCCAAGT GTCTGGGTAC TTGTAGGATG 001280
001281 GCCCTGCCAT TCCATCCAGG GGCAGTGGCA ACAGGGAGAT TCCACAAACA AAGTGAACTG GGGGATGGGA TGAGCAGGCT 001360
001361 CCAGGCAACT GAGCCCTACT GGCAGGCCCT TGGCCCCCGG GGCCGGGACA GGGGTGACAG ACACAGAGTG CCCAGGTAAC 001440
001441 CACTCCTGGG AGCAGTGGGG AACCGTCGGA TGCTTCAACT CTTGAGAGCT GGGCTCTAAG CATCCGCCTT AGCTGCCAAC 001520
001521 TTGGCCAAAG GCTATGCGAG CAGTTTCCCG TTGACGGGCA ATGCATCTTT CCAACCTGAG CGAGTGGGTG TGTGTGCAAA 001600
001601 GATGGTGCGA GTCACGGATC TGCGCAGGAA GGGTGACT