Difference between revisions of "SPINT1-AS1"
Guangyu Wang (talk | contribs) (Created page with "==Annotated Information== ===Approved Symbol=== SPINT1-AS1 ===Approved Name=== SPINT1 antisense RNA 1 ===Previous Symbols=== _ ===Synonyms=== RP11-532F12.5 ===Chromosome=== 15...") |
Jiabao Cao (talk | contribs) |
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==Annotated Information== | ==Annotated Information== | ||
| − | === | + | ===Name=== |
| − | SPINT1-AS1 | + | SPINT1-AS1:SPINT1 antisense RNA 1 |
| − | === | + | |
| − | + | ||
| − | === | + | RP11-532F12.5<ref name="ref1" /> |
| − | + | ||
| − | === | + | ===Function=== |
| − | RP11-532F12.5 | + | Interestingly, an analysis of the RP11-532F12.5 genomic locus showes that RHOV is its near coding gene (38 kb away). RP11-532F12.5 might regulate the expression of neighboring protein-coding genes and influence the development and progression of melanoma. RHOV, which is co-expressed with RP11-532F12.5(PCC = 0.943 in metastatic melanoma vs. normal skin tissues), is an apoptosis-associated genes in the Rho GTPase family. <ref name="ref1" /> |
| − | === | + | |
| − | + | ===Diseases=== | |
| − | == | + | Melanoma<ref name="ref1" /> |
| − | + | ===Expression=== | |
| − | == | + | RP11-532F12.5 is downregulated with a log2 FC of -4.971 in metastatic melanoma(MM) when compared with normal skin tissues. <ref name="ref1" /> |
| − | + | ||
| − | + | ===Sequence=== | |
| − | + | >NR_146466.1 Homo sapiens SPINT1 antisense RNA 1 (SPINT1-AS1), transcript variant 1, long non-coding RNA | |
| − | + | <dnaseq>AGCGCGGGCCTCTGGGTTCCGAGGGTGCTGGTGACCTGAGAAGAAGGGAGGGGACAGAGGAGGAGACACA | |
| − | + | CCTGATCAGCCCGGGAGACTTTGGAGGAGGCGGGCCGGCCGGGAGGAAGTGGCGGGGAGGAGGGACCGGA | |
| + | GCACCCCAGGATCGAAGAGGGCGCACGGGCCCGGCCCTCCCACGCGCCCTCCAGGGACCCGGCAGCCAGA | ||
| + | CAGACGGACAGGCGGACCGCTAGGGAGCTCAAGTACCCGGACACACGCACGAGCGCAGAACAAAGGGCCG | ||
| + | GACATGCTCCAGCCCGCTCCGCCTGCGCCTCGGCCTTGCGCGCGGGGGCCCGGGTTACCTGCGCAGAGCC | ||
| + | AGCTGTGATGTAAAGAAGTTTGTGCTGCATGAGAGAGATAGCACCTGAAGAAAATGAGGCCCTGGAGGAT | ||
| + | GAGAGACTCTAAAGGAAAAGGGAAGGGCCTGCTGTCTTCCAGCCACGCCAGCCCCCAACTGAGAAGCTGG | ||
| + | TGCCCTTGGTGTGGTGGAAGCAAGGTGCCATGTGATAAGTAAGCCTCCAGAGAGGCCTGCATGGCAGGAT | ||
| + | CCAATGTCTTTAGCCAACAGCATCTGGGAACCTGAGACCTGCCAACACCCTTGTGAGTGAGCCTGGAAGT | ||
| + | GGACCTCCTGCTCTTGAACCTTGAGGTGACTATAGTGCTGGCTGACACCTTGACTGCAGTCCCTGAGCTG | ||
| + | GGGGGCCCAGCTGATCTACTCCCAGAATCCCCCCTACTAAAACAGTGATATAATAAATGCTTATTGTTTC | ||
| + | AAGCTGGTAAAAAAAAAAAAAAAAA</dnaseq> | ||
| + | ==Labs working on this lncRNA== | ||
| + | *Department of Radiology, Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China. | ||
| + | ==References== | ||
| + | <references> | ||
| + | <ref name="ref1"> | ||
| + | Wang S, Fan W, Wan B, Tu M, Jin F, Liu F, Xu H, Han P. Characterization of | ||
| + | long noncoding RNA and messenger RNA signatures in melanoma tumorigenesis and | ||
| + | metastasis. PLoS One. 2017 Feb 22;12(2). | ||
| + | </ref> | ||
| + | </references> | ||
Revision as of 03:20, 27 August 2017
Contents
Annotated Information
Name
SPINT1-AS1:SPINT1 antisense RNA 1
RP11-532F12.5[1]
Function
Interestingly, an analysis of the RP11-532F12.5 genomic locus showes that RHOV is its near coding gene (38 kb away). RP11-532F12.5 might regulate the expression of neighboring protein-coding genes and influence the development and progression of melanoma. RHOV, which is co-expressed with RP11-532F12.5(PCC = 0.943 in metastatic melanoma vs. normal skin tissues), is an apoptosis-associated genes in the Rho GTPase family. [1]
Diseases
Melanoma[1]
Expression
RP11-532F12.5 is downregulated with a log2 FC of -4.971 in metastatic melanoma(MM) when compared with normal skin tissues. [1]
Sequence
>NR_146466.1 Homo sapiens SPINT1 antisense RNA 1 (SPINT1-AS1), transcript variant 1, long non-coding RNA
000001 AGCGCGGGCC TCTGGGTTCC GAGGGTGCTG GTGACCTGAG AAGAAGGGAG GGGACAGAGG AGGAGACACA CCTGATCAGC 000080
000081 CCGGGAGACT TTGGAGGAGG CGGGCCGGCC GGGAGGAAGT GGCGGGGAGG AGGGACCGGA GCACCCCAGG ATCGAAGAGG 000160
000161 GCGCACGGGC CCGGCCCTCC CACGCGCCCT CCAGGGACCC GGCAGCCAGA CAGACGGACA GGCGGACCGC TAGGGAGCTC 000240
000241 AAGTACCCGG ACACACGCAC GAGCGCAGAA CAAAGGGCCG GACATGCTCC AGCCCGCTCC GCCTGCGCCT CGGCCTTGCG 000320
000321 CGCGGGGGCC CGGGTTACCT GCGCAGAGCC AGCTGTGATG TAAAGAAGTT TGTGCTGCAT GAGAGAGATA GCACCTGAAG 000400
000401 AAAATGAGGC CCTGGAGGAT GAGAGACTCT AAAGGAAAAG GGAAGGGCCT GCTGTCTTCC AGCCACGCCA GCCCCCAACT 000480
000481 GAGAAGCTGG TGCCCTTGGT GTGGTGGAAG CAAGGTGCCA TGTGATAAGT AAGCCTCCAG AGAGGCCTGC ATGGCAGGAT 000560
000561 CCAATGTCTT TAGCCAACAG CATCTGGGAA CCTGAGACCT GCCAACACCC TTGTGAGTGA GCCTGGAAGT GGACCTCCTG 000640
000641 CTCTTGAACC TTGAGGTGAC TATAGTGCTG GCTGACACCT TGACTGCAGT CCCTGAGCTG GGGGGCCCAG CTGATCTACT 000720
000721 CCCAGAATCC CCCCTACTAA AACAGTGATA TAATAAATGC TTATTGTTTC AAGCTGGTAA AAAAAAAAAA AAAAA
000081 CCGGGAGACT TTGGAGGAGG CGGGCCGGCC GGGAGGAAGT GGCGGGGAGG AGGGACCGGA GCACCCCAGG ATCGAAGAGG 000160
000161 GCGCACGGGC CCGGCCCTCC CACGCGCCCT CCAGGGACCC GGCAGCCAGA CAGACGGACA GGCGGACCGC TAGGGAGCTC 000240
000241 AAGTACCCGG ACACACGCAC GAGCGCAGAA CAAAGGGCCG GACATGCTCC AGCCCGCTCC GCCTGCGCCT CGGCCTTGCG 000320
000321 CGCGGGGGCC CGGGTTACCT GCGCAGAGCC AGCTGTGATG TAAAGAAGTT TGTGCTGCAT GAGAGAGATA GCACCTGAAG 000400
000401 AAAATGAGGC CCTGGAGGAT GAGAGACTCT AAAGGAAAAG GGAAGGGCCT GCTGTCTTCC AGCCACGCCA GCCCCCAACT 000480
000481 GAGAAGCTGG TGCCCTTGGT GTGGTGGAAG CAAGGTGCCA TGTGATAAGT AAGCCTCCAG AGAGGCCTGC ATGGCAGGAT 000560
000561 CCAATGTCTT TAGCCAACAG CATCTGGGAA CCTGAGACCT GCCAACACCC TTGTGAGTGA GCCTGGAAGT GGACCTCCTG 000640
000641 CTCTTGAACC TTGAGGTGAC TATAGTGCTG GCTGACACCT TGACTGCAGT CCCTGAGCTG GGGGGCCCAG CTGATCTACT 000720
000721 CCCAGAATCC CCCCTACTAA AACAGTGATA TAATAAATGC TTATTGTTTC AAGCTGGTAA AAAAAAAAAA AAAAA
Labs working on this lncRNA
- Department of Radiology, Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China.
