Difference between revisions of "LINP1"
Guangyu Wang (talk | contribs) (Created page with "==Annotated Information== ===Approved Symbol=== LINP1 ===Approved Name=== lncRNA in non-homologous end joining pathway 1 ===Previous Symbols=== _ ===Synonyms=== _ ===Chromosom...") |
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==Annotated Information== | ==Annotated Information== | ||
| + | [[File:Expression and genomic alteration of LINP1 in breast cancer.jpg|right|thumb|400px|'''Expression and genomic alteration of LINP1 in breast cancer'''<ref name="ref1" />]] | ||
| + | [[File:LINP1 RNA associates with Ku80 and DNA-PKcs.jpg|right|thumb|400px|'''LINP1 RNA associates with Ku80 and DNA-PKcs'''<ref name="ref1" />]] | ||
| + | [[File:LINP1 serves as a modular scaffold in the NHEJ pathway.jpg|right|thumb|400px|'''LINP1 serves as a modular scaffold in the NHEJ pathway'''<ref name="ref1" />]] | ||
===Approved Symbol=== | ===Approved Symbol=== | ||
| − | LINP1 | + | LINP1 (lncRNA in non-homologous end joining pathway 10 |
| − | |||
| − | lncRNA in non-homologous end joining pathway | ||
| − | |||
| − | |||
| − | |||
| − | |||
===Chromosome=== | ===Chromosome=== | ||
10p14 | 10p14 | ||
===RefSeq ID=== | ===RefSeq ID=== | ||
NR_138480 | NR_138480 | ||
| − | |||
| − | |||
| − | |||
| − | |||
===pubmed IDs=== | ===pubmed IDs=== | ||
27111890 | 27111890 | ||
| + | ===Expression=== | ||
| + | Compared with the non-basal lines, LINP1 has significantly higher expression level. <ref name="ref1" /> | ||
| + | ===Function=== | ||
| + | LINP1 serves as a modular scaffold and uses different regions to interact with the two proteins Ku80 and DNA-PKcs which participate in the NHEJ pathway. <ref name="ref1" /> | ||
| + | Suppressing LINP1 expression can impair DNA repair activity in vivo, which in turn sensitizes tumors to IR treatment.<ref name="ref1" /> | ||
| + | ===Regulation=== | ||
| + | LINP1 is activated by the EGF (RAS-MEK-JNK) pathway and repressed by the p53 signaling pathway. <ref name="ref1" /> | ||
| + | ==Labs working on this lncRNA== | ||
| + | * Center for Research on Reproduction &Women's Health, University of Pennsylvania, Philadelphia, Pennsylvania, USA. | ||
| + | * Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, Pennsylvania, USA. | ||
| + | ==References== | ||
| + | <references> | ||
| + | <ref name="ref1"> Zhang, Y., et al., Long noncoding RNA LINP1 regulates repair of DNA double-strand breaks in triple-negative breast cancer. Nat Struct Mol Biol, 2016. 23(6): p. 522-30. | ||
| + | </ref>(1) | ||
| + | </references> | ||
Revision as of 14:17, 22 October 2017
Contents
Annotated Information
Expression and genomic alteration of LINP1 in breast cancer[1]
LINP1 RNA associates with Ku80 and DNA-PKcs[1]
LINP1 serves as a modular scaffold in the NHEJ pathway[1]
Approved Symbol
LINP1 (lncRNA in non-homologous end joining pathway 10
Chromosome
10p14
RefSeq ID
NR_138480
pubmed IDs
27111890
Expression
Compared with the non-basal lines, LINP1 has significantly higher expression level. [1]
Function
LINP1 serves as a modular scaffold and uses different regions to interact with the two proteins Ku80 and DNA-PKcs which participate in the NHEJ pathway. [1] Suppressing LINP1 expression can impair DNA repair activity in vivo, which in turn sensitizes tumors to IR treatment.[1]
Regulation
LINP1 is activated by the EGF (RAS-MEK-JNK) pathway and repressed by the p53 signaling pathway. [1]
Labs working on this lncRNA
- Center for Research on Reproduction &Women's Health, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
- Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
