Difference between revisions of "FLNC-AS1"
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==Annotated Information== | ==Annotated Information== | ||
| − | === | + | ===Name=== |
| − | FLNC-AS1 | + | FLNC-AS1:FLNC antisense RNA 1 |
| − | + | ||
| − | FLNC antisense RNA 1 | + | ENST00000447565 <ref name="ref1" /> |
| − | === | + | ===Characteristics=== |
| − | + | ENST00000447565 is a LIF (leukemia inhibitor factor) natural antisense lncRNA. <ref name="ref1" /> | |
| − | === | + | |
| − | + | ===Function=== | |
| − | === | + | Lnc-LIF-AS can regulate the stability of LIF mRNA by over-lapping a 3′-UTR of LIF mRNA which might contribute to inhibit the degradation of LIF mRNA mediated by other RNAs.<ref name="ref1" /> |
| − | + | ===Regulation=== | |
| − | === | + | The expression ofΔNp63α can directly inhibitLIF mRNA transcription and decrease LIF mRNA stability by suppressing the expression of Lnc-LIF-AS.<ref name="ref1" /> |
| − | + | ===Diseases=== | |
| − | === | + | Cervical squamous cancers<ref name="ref1" /> |
| − | + | ===Expression=== | |
| − | === | + | ENST00000447565 is significantly downregulated expression in SiHa/ΔNp63αstable cell lines. |
| − | + | In addition, Lnc-LIF-AS is also shown gradually up-regulated with the increase of ΔNp63α siRNAs. <ref name="ref1" /> | |
| − | == | + | |
| − | + | ==Labs working on this lncRNA== | |
| − | + | *Department of Obstetrics and Gynecology, Anhui Provincial Hospital, Anhui Medical University, Hefei 230001, China. | |
| − | + | ==References== | |
| + | <references> | ||
| + | <ref name="ref1"> | ||
| + | Qian L, Xu F, Wang X, Jiang M, Wang J, Song W, Wu D, Shen Z, Feng D, Ling B, | ||
| + | Cheng Y, Xiao W, Shan G, Zhou Y. LncRNA expression profile of ΔNp63α in cervical | ||
| + | squamous cancers and its suppressive effects on LIF expression. Cytokine. 2017 | ||
| + | Aug;96:114-122. | ||
| + | </ref> | ||
| + | </references> | ||
Revision as of 02:34, 13 August 2017
Contents
Annotated Information
Name
FLNC-AS1:FLNC antisense RNA 1
ENST00000447565 [1]
Characteristics
ENST00000447565 is a LIF (leukemia inhibitor factor) natural antisense lncRNA. [1]
Function
Lnc-LIF-AS can regulate the stability of LIF mRNA by over-lapping a 3′-UTR of LIF mRNA which might contribute to inhibit the degradation of LIF mRNA mediated by other RNAs.[1]
Regulation
The expression ofΔNp63α can directly inhibitLIF mRNA transcription and decrease LIF mRNA stability by suppressing the expression of Lnc-LIF-AS.[1]
Diseases
Cervical squamous cancers[1]
Expression
ENST00000447565 is significantly downregulated expression in SiHa/ΔNp63αstable cell lines. In addition, Lnc-LIF-AS is also shown gradually up-regulated with the increase of ΔNp63α siRNAs. [1]
Labs working on this lncRNA
- Department of Obstetrics and Gynecology, Anhui Provincial Hospital, Anhui Medical University, Hefei 230001, China.
