Difference between revisions of "DM1-AS"
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===Name=== | ===Name=== | ||
DM1-AS:DM1 locus antisense RNA | DM1-AS:DM1 locus antisense RNA | ||
| + | |||
===Characteristics=== | ===Characteristics=== | ||
| − | DM1-AS spans >6 kb, contains alternative transcription start sites and uses alternative polyadenylation sites up- and downstream of the (CAG)n repeat. <ref name="ref1" /> | + | DM1-AS spans >6 kb, contains alternative transcription start sites and uses alternative polyadenylation sites up- and downstream of the (CAG)n repeat <ref name="ref1" />. Thus, a mixture of DM1-AS RNAs with and without expanded (CAG)n repeat are produced in patients <ref name="ref1" />. |
===Cellular Localization=== | ===Cellular Localization=== | ||
| − | DM1-AS transcripts are present in the nucleus and | + | DM1-AS transcripts are present in both the nucleus and the cytoplasm <ref name="ref1" />. |
===Expression=== | ===Expression=== | ||
[[File:DM1-AS.jpg|right|thumb|400px|'''The DM1-AS transcript is a low-abundance RNA'''<ref name="ref1" />.]] | [[File:DM1-AS.jpg|right|thumb|400px|'''The DM1-AS transcript is a low-abundance RNA'''<ref name="ref1" />.]] | ||
| − | DM1-AS expression appears upregulated in patients, but transcript abundance remains very low | + | DM1-AS expression appears upregulated in patients, but transcript abundance remains very low <ref name="ref1" />. Comparison among different tissues show that DM1-AS expression is lowest in brain and highest in kidney, testis and muscle <ref name="ref1" />. |
===Diseases=== | ===Diseases=== | ||
| − | Myotonic dystrophy type 1<ref name="ref1" /> | + | Myotonic dystrophy type 1 <ref name="ref1" /> |
==Labs working on this lncRNA== | ==Labs working on this lncRNA== | ||
| − | * a Radboud University Medical Center , Department of Cell Biology , Nijmegen , The Netherlands. | + | * a Radboud University Medical Center, Department of Cell Biology, Nijmegen, The Netherlands. |
| + | |||
==References== | ==References== | ||
<references> | <references> | ||
| − | <ref name="ref1"> | + | <ref name="ref1">Gudde AEEG, van Heeringen SJ, de Oude AI, van Kessel IDG, Estabrook J, Wang ET, Wieringa B, Wansink DG. Antisense transcription of the myotonic dystrophy locus yields low-abundant RNAs with and without (CAG)n repeat. RNA Biol. 2017 Jan 19:1-15.</ref> |
| − | Gudde AEEG, van Heeringen SJ, de Oude AI, van Kessel IDG, Estabrook J, Wang | ||
| − | ET, Wieringa B, Wansink DG. Antisense transcription of the myotonic dystrophy | ||
| − | locus yields low-abundant RNAs with and without (CAG)n repeat. RNA Biol. 2017 Jan | ||
| − | 19:1-15. | ||
| − | </ref> | ||
</references> | </references> | ||
Revision as of 09:23, 28 September 2017
Contents
Annotated Information
Name
DM1-AS:DM1 locus antisense RNA
Characteristics
DM1-AS spans >6 kb, contains alternative transcription start sites and uses alternative polyadenylation sites up- and downstream of the (CAG)n repeat [1]. Thus, a mixture of DM1-AS RNAs with and without expanded (CAG)n repeat are produced in patients [1].
Cellular Localization
DM1-AS transcripts are present in both the nucleus and the cytoplasm [1].
Expression
The DM1-AS transcript is a low-abundance RNA[1].
DM1-AS expression appears upregulated in patients, but transcript abundance remains very low [1]. Comparison among different tissues show that DM1-AS expression is lowest in brain and highest in kidney, testis and muscle [1].
Diseases
Myotonic dystrophy type 1 [1]
Labs working on this lncRNA
- a Radboud University Medical Center, Department of Cell Biology, Nijmegen, The Netherlands.
