Difference between revisions of "SMILR"
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===Characteristics=== | ===Characteristics=== | ||
| − | The longest open reading frame(ORF) within SMILR is 57 amino acids. | + | The longest open reading frame(ORF) within SMILR is 57 amino acids. |
[[File:Localization of SMILR.jpg|right|thumb|300px|'''Localization of SMILR.(A)RNA FISH analysis of SMILR,cytoplasmic UBC mRNA,and nuclear SNORD3 RNA in HSVSMC.(B)25±5 individual SMILR molecules were observed within the nucleus and cytoplasm.''' <ref name="ref1" />.]] | [[File:Localization of SMILR.jpg|right|thumb|300px|'''Localization of SMILR.(A)RNA FISH analysis of SMILR,cytoplasmic UBC mRNA,and nuclear SNORD3 RNA in HSVSMC.(B)25±5 individual SMILR molecules were observed within the nucleus and cytoplasm.''' <ref name="ref1" />.]] | ||
Revision as of 15:25, 23 September 2017
Contents
Annotated Information
Approved Symbol
SMILR
Approved Name
"smooth muscle induced lncRNA, enhancer of proliferation"
Chromosome
8q24.13
RefSeq(supplied by NCBI)
NR_131202
Characteristics
The longest open reading frame(ORF) within SMILR is 57 amino acids.
Localization of SMILR.(A)RNA FISH analysis of SMILR,cytoplasmic UBC mRNA,and nuclear SNORD3 RNA in HSVSMC.(B)25±5 individual SMILR molecules were observed within the nucleus and cytoplasm. [1].
Expression
SMILR is expressed highest in the heart and it is a differentially expressed lncRNA in human saphenous vein-derived smooth muscle cells [1].
Cellular Localization
SMILR locates in the nucleus and cytoplasm [1].
Function
SMILR regulates the expression of the nearby gene HAS2. Knockdown experiment shows SMILR is a driver gene and can regulate vascular smooth muscle cell proliferation [1].
Regulation
SMILR expression can be regulated by IL1α or PDGF and it is a time-dependent manner [1].
pubmed IDs
27052414
