Difference between revisions of "LINC01844"
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==Annotated Information== | ==Annotated Information== | ||
| + | [[File:Expression of LOC101926975 in HSCR.png|right|thumb|500px|'''LOC101926975 is significantly downregulated in HSCR tissues compared control samples'''.<ref name="ref1" />]] | ||
| + | [[File:Function of LOC101926975 in vitro.jpg|right|thumb|400px|'''(A) LOC101926975 was effectively knocked down in SK-N-BE(2) cells. Downregulation of LOC101926975 suppressed cell proliferation (B)and caused cell cycle arrest (C)without impact on cell apoptosis (D)or cell migration.'''.<ref name="ref1" />]] | ||
===Approved Symbol=== | ===Approved Symbol=== | ||
LINC01844 | LINC01844 | ||
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===Synonyms=== | ===Synonyms=== | ||
LOC101926975 | LOC101926975 | ||
| − | |||
| − | |||
===Chromosome=== | ===Chromosome=== | ||
5q31.3 | 5q31.3 | ||
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NR_110558 | NR_110558 | ||
===Characteristics=== | ===Characteristics=== | ||
| − | LOC101926975 locates on chromosome 5 (142745600-142760993) and it is near the gene FGF1. <ref name="ref1" /> | + | LOC101926975 locates on chromosome 5 (142745600-142760993) and it is near the gene FGF1.<ref name="ref1" /> |
===Expression=== | ===Expression=== | ||
| − | Compared with the control tissues, the expression of LOC101926975 is down-regulated in hirschsprung disease (HSCR) tissues. <ref name="ref1" /> | + | Compared with the control tissues, the expression of LOC101926975 is down-regulated in hirschsprung disease (HSCR) tissues.<ref name="ref1" /> |
{| class='wikitable' style="text-align:center" | {| class='wikitable' style="text-align:center" | ||
|- | |- | ||
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|} | |} | ||
===Function=== | ===Function=== | ||
| − | SiRNA experiment show that LOC101926975 knockdown inhibits cell proliferation and blocks the G0/G1 to S phase transition. | + | SiRNA experiment show that LOC101926975 knockdown inhibits cell proliferation and blocks the G0/G1 to S phase transition.<ref name="ref1" /> |
| − | + | The expression correlation analysis shows LOC101926975 regulate the expression of FGF1.<ref name="ref1" /> | |
| − | + | ==Labs working on this lncRNA== | |
| − | == | + | * Department of Pediatric Surgery, Nanjing Children's Hospital Affiliated Nanjing Medical University, Nanjing 210008; 2. State Key Laboratory of Reproductive Medicine, Institute of Toxicology, School of Public Health, Nanjing Medical University, Nanjing 211166, China. |
| − | + | * State Key Laboratory of Reproductive Medicine, Institute of Toxicology, School of Public Health, Nanjing Medical University, Nanjing 211166, China; 3. Key Laboratory of Modern Toxicology (Nanjing Medical University), Ministry of Education, China. | |
| + | ==References== | ||
| + | <references> | ||
| + | <ref name="ref1"> | ||
| + | </ref>(1) | ||
| + | </references> | ||
Revision as of 13:28, 22 October 2017
Contents
Annotated Information
LOC101926975 is significantly downregulated in HSCR tissues compared control samples.[1]
(A) LOC101926975 was effectively knocked down in SK-N-BE(2) cells. Downregulation of LOC101926975 suppressed cell proliferation (B)and caused cell cycle arrest (C)without impact on cell apoptosis (D)or cell migration..[1]
Approved Symbol
LINC01844
Approved Name
long intergenic non-protein coding RNA 1844
Synonyms
LOC101926975
Chromosome
5q31.3
RefSeq ID
NR_110558
RefSeq(supplied by NCBI)
NR_110558
Characteristics
LOC101926975 locates on chromosome 5 (142745600-142760993) and it is near the gene FGF1.[1]
Expression
Compared with the control tissues, the expression of LOC101926975 is down-regulated in hirschsprung disease (HSCR) tissues.[1]
| Experiment | Forward primer | Reverse primer |
|---|---|---|
| qRT-PCR | 5'-AACCCAGTGTTCAAAACCCCA- 3' | 5'-GCAGGGGAAAATACCAGGGAA- 3'[1] |
Function
SiRNA experiment show that LOC101926975 knockdown inhibits cell proliferation and blocks the G0/G1 to S phase transition.[1] The expression correlation analysis shows LOC101926975 regulate the expression of FGF1.[1]
Labs working on this lncRNA
- Department of Pediatric Surgery, Nanjing Children's Hospital Affiliated Nanjing Medical University, Nanjing 210008; 2. State Key Laboratory of Reproductive Medicine, Institute of Toxicology, School of Public Health, Nanjing Medical University, Nanjing 211166, China.
- State Key Laboratory of Reproductive Medicine, Institute of Toxicology, School of Public Health, Nanjing Medical University, Nanjing 211166, China; 3. Key Laboratory of Modern Toxicology (Nanjing Medical University), Ministry of Education, China.
