Difference between revisions of "MELTF-AS1"
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==Annotated Information== | ==Annotated Information== | ||
| − | [[File: lncRNA MFI2 is upregulated in human osteosarcoma tissues and osteosarcoma cell lines.jpg|right|thumb|400px|'''lncRNA | + | [[File: lncRNA MFI2 is upregulated in human osteosarcoma tissues and osteosarcoma cell lines.jpg|right|thumb|400px|'''lncRNA MELTF-AS1 is upregulated in human osteosarcoma tissues and osteosarcoma cell lines''' <ref name="ref1" />.]] |
| − | [[File: Knockdown of MFI2 suppresses osteosarcoma cell proliferation.jpg|right|thumb|400px|'''Knockdown of | + | [[File: Knockdown of MFI2 suppresses osteosarcoma cell proliferation.jpg|right|thumb|400px|'''Knockdown of MELTF-AS1 suppresses osteosarcoma cell proliferation''' <ref name="ref1" />.]] |
| − | [[File: Correlation between MFI2 expression level and FOXP4 protein expression in osteosarcoma.jpg|right|thumb|400px|'''Correlation between | + | [[File: Correlation between MFI2 expression level and FOXP4 protein expression in osteosarcoma.jpg|right|thumb|400px|'''Correlation between MELTF-AS1 expression level and FOXP4 protein expression in osteosarcoma''' <ref name="ref1" />.]] |
===Approved Symbol=== | ===Approved Symbol=== | ||
MELTF-AS1 (MELTF antisense RNA 1) | MELTF-AS1 (MELTF antisense RNA 1) | ||
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osteosarcoma | osteosarcoma | ||
===Expression=== | ===Expression=== | ||
| − | Compared with corresponding adjacent, histological normal tissues, | + | Compared with corresponding adjacent, histological normal tissues, MELTF-AS1 was significantly upregulated in human osteosarcoma tissues (P<0.0001).<ref name="ref1" /> |
FOXP4 protein is upregulated in osteosarcoma tissues and positively correlated with MFI2 expression.<ref name="ref1" /> | FOXP4 protein is upregulated in osteosarcoma tissues and positively correlated with MFI2 expression.<ref name="ref1" /> | ||
===Function=== | ===Function=== | ||
| − | Knockdown of | + | Knockdown of MELTF-AS1 inhibits osteosarcoma cell migration, invasion and proliferation. However,knockdown of MELTF-AS1 promotes osteosarcoma cell apoptosis in vitro.<ref name="ref1" /> |
==Labs working on this lncRNA== | ==Labs working on this lncRNA== | ||
Revision as of 10:33, 19 November 2017
Contents
Annotated Information
lncRNA MELTF-AS1 is upregulated in human osteosarcoma tissues and osteosarcoma cell lines [1].
Knockdown of MELTF-AS1 suppresses osteosarcoma cell proliferation [1].
Correlation between MELTF-AS1 expression level and FOXP4 protein expression in osteosarcoma [1].
Approved Symbol
MELTF-AS1 (MELTF antisense RNA 1)
Previous Symbols
MFI2-AS1
Chromosome
3q29
RefSeq(supplied by NCBI)
NR_038285
Disease
osteosarcoma
Expression
Compared with corresponding adjacent, histological normal tissues, MELTF-AS1 was significantly upregulated in human osteosarcoma tissues (P<0.0001).[1] FOXP4 protein is upregulated in osteosarcoma tissues and positively correlated with MFI2 expression.[1]
Function
Knockdown of MELTF-AS1 inhibits osteosarcoma cell migration, invasion and proliferation. However,knockdown of MELTF-AS1 promotes osteosarcoma cell apoptosis in vitro.[1]
Labs working on this lncRNA
- Department of Orthopaedic Surgery, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510120, P.R. China.
- Department of Anatomy, Guangzhou Medical University, Guangzhou, Guangdong 510182, P.R. China.
