Difference between revisions of "TRPM2-AS"
| Line 1: | Line 1: | ||
==Annotated Information== | ==Annotated Information== | ||
===Approved Symbol=== | ===Approved Symbol=== | ||
| − | TRPM2-AS | + | ===Name=== |
| + | Approved symbol: TRPM2-AS | ||
| + | |||
| + | Approved name: TRPM2 antisense RNA | ||
| + | |||
| + | HGNC ID: HGNC:50758 | ||
| + | |||
| + | Alias symbols: TRPM2-AS1 | ||
| + | |||
| + | RefSeq ID: NR_109964 | ||
| + | |||
| + | LncBook ID: [https://bigd.big.ac.cn/lncbook/transcript?transid=HSALNT0289414 HSALNT0289414] | ||
| + | |||
[[File: Identification of an antisense transcript and related molecules within the human TRPM2 gene on chromosome 21.jpg|right|thumb|400px|'''Identification of an antisense transcript and related molecules within the human TRPM2 gene on chromosome 21.''' <ref name="ref1" />.]] | [[File: Identification of an antisense transcript and related molecules within the human TRPM2 gene on chromosome 21.jpg|right|thumb|400px|'''Identification of an antisense transcript and related molecules within the human TRPM2 gene on chromosome 21.''' <ref name="ref1" />.]] | ||
[[File: Expression analysis of TRPM2-AS.png|right|thumb|400px|'''Expression analysis of TRPM2-AS.''' <ref name="ref1" />.]] | [[File: Expression analysis of TRPM2-AS.png|right|thumb|400px|'''Expression analysis of TRPM2-AS.''' <ref name="ref1" />.]] | ||
Revision as of 14:37, 10 August 2019
Contents
Annotated Information
Approved Symbol
Name
Approved symbol: TRPM2-AS
Approved name: TRPM2 antisense RNA
HGNC ID: HGNC:50758
Alias symbols: TRPM2-AS1
RefSeq ID: NR_109964
LncBook ID: HSALNT0289414
Synonyms
TRPM2-AS1
Chromosome
21q22.3
RefSeq ID
NR_109964
Disease
cancer
Ensembl ID
ENSG00000230061
Characteristics
TRPM2-AS is antisense with respect to TRPM2, an ion channel capable of conferring cell death upon oxidative stress.[1]
Regulation
The CpG island could be involved in the transcriptional regulation of TRPM2-AS,specifically,the methylation status of the CpG island contributes negatively to the expression level of both TRPM2-AS.[1]
Expression
TRPM2-AS transcripts is up-regulated in melanoma, and their activation is consistent with the methylation status of the shared CpG island.[1] Tumor samples displayed higher levels of TRPM2-AS and TRPM2-TE transcripts with respect to their matched normal tissue. [1]
Labs working on this lncRNA
- DIBIT-San Raffaele Scientific Institute, Via Olgettina 58, 20132 Milan, Italy. [1]
References
Sequence
>gi|568786345|ref|NR_109964.1| Homo sapiens TRPM2 antisense RNA (TRPM2-AS), long non-coding RNA
000081 CGGGAGCTCA GGCAGCGTCC CCGCCGGCAC CTGCCTCTTT GTGCAGCGGC AGTCAGGGCC CTCGGCAATG AGCTGAACTC 000160
000161 GCAGTGCGGT TACGAGGGCA AATATGCTCC TTGAGGGCCG GCGAAACTCA GCAGCCCGAG GAAGGCTACT GATGTGCATT 000240
000241 TCATAGCCGG CTGCGAATTT AGGAAAACAG ACTTTGCTTC TCGTCACTCA GCCTACGTGA CCAGGTTCAG ACACAGTCTG 000320
000321 CAGCCGCCCG CCTCGCACCC CCACTCTGCA GTGCGGTATG TGGGGAGCTC AGGGCACAGC AGGCCAGGCC TCCCCGTGGA 000400
000401 CGTCCAGGAA CCAGAACCAA ACTGCCCAGG GCCCCAGAGG GGAAGATGTC TCAGCAGACG GACAGCCGAG GCTCACATGG 000480
000481 CAAGCTCTGG CAGCCTGTCG GTCCCAGGAG AGAGGGGGAG ATGGCAGACG GGAAAAGAAG CCACCTGCTG GGATGCTGAG 000560
000561 ACTCGCTTGC AGGAGCTTTT GGAACTGGCT GAGGTCACAG CTGGAACCAC TGTGGCCAGC TGGAGTCTGC ACAGCCCGAG 000640
000641 TTTCCACCCC AGGGTCCCAG TAACTCCGCC CAAATGTGCA CACGAGACCT ATGAGGAGAC ATAACTTTCC AGAACCCCCT 000720
000721 TTTCTTCCAC CAGCCACTTA CTCATCCAAG AACCCACCCC CGAACCTTCC CTAATAGAAA CACTGCATTA AAGCCAGCGC 000800
000801 GGGGAGACAG ACGTGAACTG CGCCCCTGTC TCCTTGTGGG TTGGCCTAGA ATAAAAGCTT TTCTTTTCTC AAAAA
