Difference between revisions of "TFAP2A-AS2"
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===Function=== | ===Function=== | ||
| − | [[File:HIPSTR func.jpg|right|thumb| | + | [[File:HIPSTR func.jpg|right|thumb|200px|'''Developmental genes are affected by HIPSTR knockdown in HEK293 and H1BP cells'''<ref name="ref1" />.]] |
HIPSTR promoter is most active in undifferentiated cells, and depletion of HIPSTR in HEK293 and in pluripotent H1BP cells predominantly affects the genes involved in early organismal development and cell differentiation. | HIPSTR promoter is most active in undifferentiated cells, and depletion of HIPSTR in HEK293 and in pluripotent H1BP cells predominantly affects the genes involved in early organismal development and cell differentiation. | ||
Revision as of 15:35, 8 December 2017
Contents
Annotated Information
Name
TFAP2A-AS2:TFAP2A antisense RNA 2
HIPSTR.[1]
Characteristics
HIPSTR (Heterogeneously expressed from the Intronic Plus Strand of the TFAP2A-locus RNA) is a novel lncRNA gene in the developmentally regulated TFAP2A locus.[1]
Function
HIPSTR promoter is most active in undifferentiated cells, and depletion of HIPSTR in HEK293 and in pluripotent H1BP cells predominantly affects the genes involved in early organismal development and cell differentiation.
Regulation
HIPSTR promoter can be stimulated by TFAP2A, but HIPSTR and TFAP2A are not consistently co-induced in developmental models in vitro.[1]
Expression
HIPSTR is a bona fide antisense lncRNA. And HIPSTR has an evolutionarily conserved tissue-specific expression pattern, and that it is predominantly expressed in testis and placenta of mouse (Mouse ENCODE Project RNA-seq data) and of human. In addition, HIPSTR expression in the early human embryo is restricted to a subset of cells.[1]
Labs working on this lncRNA
- Departamento de Bioquímica, Instituto de Química, Universidade de São Paulo, 05508-000 São Paulo, SP, Brazil.
