Lnc-EPCAM-1:2

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Annotated Information

Name

BCYRN1: apoptosis associated transcript in bladder cancer BC200

Characteristics

200 nucleotide ncRNA (Tiedge (1993)) exapted from an Alu element (Watson (1987)). Transcribed by RNA polymerase III (Martignetti (1993)). Three structural domains, 5' that shares homology with Alu elements, a central A rich region and a 3' unique region (Tiedge (1993)).

Function

Binds several proteins including the signal recognition particle SRP9/14 heterodimer (Kremerskothen (1998)), eukaryotic initiation factor 4A helicase (eIF4A) (Lin (2008)) and Poly(A)-binding protein (PABP), binding to PABP requires the central A rich region (Muddashetty (2002)).

Inhibits translation in-vitro and in cultured cells similar to BC1. BC200 binding to eIF4A inhibits it by uncoupling eIF4A ATPase activity from its helicase/ duplex unwinding activity (Lin (2008)). Translational inhibition also involves BC200 binding to to PABP (Kondrashov (2005)).

Regulation

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Expression

Expressed predominantly in different regions of the brain. Also shows low level expression in testis but not in other normal tissues examined (Watson (1987), Tiedge (1993), Kuryshev (2001)). RNA sequencing of 11 human tissues confirmed up-regulation of expression in brain (hypothalamus) and low or no expression elsewhere (Castle (2010)).

Disregulated in cancer: expressed in a number of human tumours but not in corresponding normal tissue (Chen (1998)).

Link with aging and Alzheimer disease: BC200 expression decreases with aging but is upregulated in Alzheimer's disease (AD). In AD affected brain regions, expression increased with disease severity. RNA localisation showed intense perikaryal staining, showing build up of RNA in cell body (Mus (2007)).

Like BC1 ncRNA found in rodents, BC200 also suggested to localise to dendrites (Tiedge (1993)).

Allelic Information and Variation

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Disease

Alzheimer's disease (Mus (2007))

Evolution

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Labs working on this lncRNA

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References

Annotation originally sourced from lncRNAdb.

Basic Information

Transcript ID	lnc-EPCAM-1:2
Source	LNCipedia2.1
Same with	,
Classification	intergenic
Length	200 nt
Genomic location	chr2+:47562453..47562653
Exon number	1
Exons	47562453..47562653
Genome context
Sequence	000001 GGCCGGGCGC GGTGGCTCAC GCCTGTAATC CCAGCTCTCA GGGAGGCTAA GAGGCGGGAG GATAGCTTGA GCCCAGGAGT 000080 000081 TCGAGACCTG CCTGGGCAAT ATAGCGAGAC CCCGTTCTCC AGAAAAAGGA AAAAAAAAAA CAAAAGACAA AAAAAAAATA 000160 000161 AGCGTAACTT CCCTCAAAGC AACAACCCCC CCCCCCCTTT

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