Difference between revisions of "NONHSAT076153"
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==Annotated Information== | ==Annotated Information== | ||
===Name=== | ===Name=== | ||
| − | PCGEM1: Prostate-specific transcript | + | PCGEM1: Prostate-specific transcript, LINC00071 (HGNC) |
===Characteristics=== | ===Characteristics=== | ||
Revision as of 03:08, 14 November 2018
Please input one-sentence summary here.
Contents
Annotated Information
Name
PCGEM1: Prostate-specific transcript, LINC00071 (HGNC)
Characteristics
PCGEM1 is located at human chromosome 2q32.3 (HGNC), containg 1603 bp and 3 exons (GenBank).
Function
Over-expression leads to inhibition of apoptosis induced by doxorubicin [1].
Disease
prostate cancer
Expression
Prostate tissue-specific and prostate cancer-associated (Srikantan 2000). Cholesterols upregulate the expression of PCGEM1 even in androgen-insensitive prostate cancer cell lines while phytosterols reverse this effect (Ifere 2009). PCGEM1 overexpression in LNCaP and in NIH3T3 cells promotes cell proliferation and a dramatic increase in colony formation, suggesting a biological role of PCGEM1 in cell growth regulation (Petrovics 2004). Low specificity as a biomarker for prostate cancer (14%) (Bialkowska-Hobrzanska 2006).
Conservation
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Misc
GWAS association with schizophrenia. PCGEM1 polymorphisms may contribute to PCa risk in Chinese men (Xue 2013)
Transcriptomic Nomeclature
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Regulation
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Allelic Information and Variation
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Evolution
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Labs working on this lncRNA
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References
- ↑ Fu X, Ravindranath L, Tran N, Petrovics G & Srivastava S. Regulation of apoptosis by a prostate-specific and prostate cancer-associated noncoding gene, PCGEM1[J]. DNA and cell biology. 2006, 25(3):135-141.
Basic Information
| Transcript ID |
NONHSAT076153 |
| Source |
NONCODE4.0 |
| Same with |
, |
| Classification |
intergenic |
| Length |
1603 nt |
| Genomic location |
chr2+:193614571..193641625 |
| Exon number |
3 |
| Exons |
193614571..193614754,193615515..193615598,193640304..193641625 |
| Genome context |
|
| Sequence |
>gi |
