Difference between revisions of "LINC-ROR"

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Loewer S, Cabili MN, Guttman M, Loh YH, Thomas K, Park IH, Garber M, Curran M,
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Loewer S, Cabili MN, Guttman M, Loh Y-H, Thomas K, Park IH et al. Large intergenic non-coding RNA-RoR modulates reprogramming of human induced pluripotent stem cells[J]. Nature genetics. 2010, 42(12):1113-1117.
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Onder T, Agarwal S, Manos PD, Datta S, Lander ES, Schlaeger TM, Daley GQ, Rinn
 
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pluripotent stem cells. Nature genetics. 2010 Dec;42(12):1113-7.
 
 
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Zhang A, Zhou N, Huang J, Liu Q, Fukuda K, Ma D, Lu Z, Bai C, Watabe K, Mo YY.
 
Zhang A, Zhou N, Huang J, Liu Q, Fukuda K, Ma D, Lu Z, Bai C, Watabe K, Mo YY.
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The human long non-coding RNA-RoR is a p53 repressor in response to DNA damage.
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The human long non-coding RNA-RoR is a p53 repressor in response to DNA damage[J].
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Cell Res. 2013 Mar;23(3):340-50.
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Wang Y, Xu Z, Jiang J, Xu C, Kang J, Xiao L, Wu M, Xiong J, Guo X, Liu H.
 
Wang Y, Xu Z, Jiang J, Xu C, Kang J, Xiao L, Wu M, Xiong J, Guo X, Liu H.
 
Endogenous miRNA sponge lincRNA-RoR regulates Oct4, Nanog, and Sox2 in human
 
Endogenous miRNA sponge lincRNA-RoR regulates Oct4, Nanog, and Sox2 in human
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embryonic stem cell self-renewal. Dev Cell. 2013 Apr 15;25(1):69-80.
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Revision as of 05:27, 19 November 2018

Annotated Information

Name

LINC-ROR:long intergenic non-protein coding RNA, regulator of reprogramming [1]

lincRNA-ST8SIA3 [1]

RoR [2]

Characteristics

The LINC-ROR gene is 2.6 kb in length, located in chromosome 18 (18q21.31), consisting of four exons [2].

Function

LINC-ROR is first found to modulate reprogramming of human induced pluripotent stem cells [1].

LINC-ROR is p53 repressor in response to DNA damage [1]. LINC-ROR can suppress p53 translation through direct interaction with the heterogeneous nuclear ribonucleoprotein I (hnRNP I), and inhibit p53-mediated cell cycle arrest and apoptosis [2].

LINC-ROR also functions as an endogenous miRNA sponge and antagonizes miR-145 to critically regulate the levels of pluripotency transcription factors Oct4, Sox2, and Nanog, in order to ensure embryonic stem cell self-renewal [3][4].

A competition for miR-145 between linc-RoR and mRNAs encoding the core TFs[4].

LINC-ROR is involved in modulation of hypoxia-signaling pathways through modulation of HIF-1a and its downstream targets [5].

Regulation

LINC-ROR and p53 form a RoR-p53 autoregulatory feedback loop where p53 transcriptionally induces RoR expression [2].

LINC-ROR transcription is mainly controlled by the core TFs Oct4, Sox2, and Nanog [1][3][4].

Diseases

malignant liver cancer [5]

Expression

LINC-ROR is highly expressed in embryonic stem cells and iPSCs [2].

In self-renewing human embryonic stem cells (hESCs), LINC-ROR is expressed at a high level [3][4].

LINC-ROR expression is increased in hypoxic regions within tumor cell xenografts in vivo and is highly expressed in extracellular RNA released by hepatocellular cancer (HCC) cells during hypoxia [5].

Sequence

>NR_048536.1 Homo sapiens long intergenic non-protein coding RNA, regulator of reprogramming (LINC-ROR), long non-coding RNA

000001 GGTGAAATAA ACAGCCATGT TGCTCACACA AAGCCTGTTT GGTGGTCTCT TCACACGGAC GCTCATGAAA TTTGGTGATG 000080
000081 TGACTCGGAT AGGGGGACCT CCCTTGGGAG ATCAGTACCC TGTCCTCCTG CTCTTTGCTC CGTGAGAAAG ATCCACCTAC 000160
000161 AACCTCAGGT CCTTAGACCA ACCAGCCCAA GAAACATCTC ACCAATTTCA AATCCAGACC CCACTGGAAA TCGGACTGTC 000240
000241 CAACTCACCT GACAGCCACT CCCACAGCCG CTGGAACTCT GGCCCAAGGC TCTCTGACTC CTTCCCAGAT CTTCTTGGCT 000320
000321 TAGCGGCTGA AGACTGACGC TGCCCGATCG CCTCGGAAGC CCCCTAGACC ATCACGGACG CCGAGCTTCG GGTAACTCTC 000400
000401 ACAGTGGAAG AAACACAACT ACAGATTTCT ACCTGGTGCA TGGCCATCGC TCATGAAGAC TACAACTTCC AGCTTCCTTT 000480
000481 GAAGAAAAAG AGGACTTGAT GGCATTGTCG CTAAGTAAGA AATAATGTGT GTGACTTCAG GGTTGCCCCC TTAAAGGGAG 000560
000561 GGGACATTTT CCATCCTGCT GTTCAGAGTA TGGATGTGAT GAGAGACATC TTGGATGATG CAGAGGAGGT GAACACCCCA 000640
000641 GGACAATGAA ACCACAGGAG AGAAAGAGCC TGCGCTGGCC CATCTAGCAC AGCCACTGGA CACAGGGACC ACCTGCCTCT 000720
000721 GCACTCTTAT GGAAGGAGGA AATCTAACTT TCCCAGTTTA AGGCACTGTT ACTTTGGGCT CCTGTTACAT AACTGTGGCA 000800
000801 GAATGAAGGT TCAACATGGA AACTGGCAAT GTTGAAGAAA CATAAAGTTC ATTGCTTGAA TATCTGAAGT TGTGGACTCA 000880
000881 ATCTCATACC TGCTCCACTT ATGAGTTATA GTTCTTCCAG GTCTCAGGAA TGGGATCAGC AGGTCTCAGG GTTGTACTCT 000960
000961 CCTGGATCTC TCACCAGCCA CCTCAAACCA GCTGCCATAG CCTGTCCACT TCCACTCCAA TCTTCTCTTC CTTCATCACC 001040
001041 TCCCTTGCAC ACCCTGATAA CCTCGAAAGA GAACTCTTCC CAAGGCTCTG TTCCAAACAC ATCGCCACTC TGCTTAGAAC 001120
001121 CTTCAATGAC TCCTCATGGC CTAGGAGGTT TCTCTCCCAT CTGGATCCAG CTGACGTTCC CAGCACCTTC TCCTGACTCC 001200
001201 TGTCTTTTCT TGAACCAGTT CTGCCCAACA AGGAGGAAAG GGCTGACAGA GTGAAAGTCC CAGGGCATGT GGGAATGTGA 001280
001281 CTCTTTTCAC TTTAAATTCT ATGACTGGAA AGTTTTGGGC AGAGTTGGAC ATGTGCACTT AGCTTCCAGA AGACAGAATC 001360
001361 CTTTTAAAAG AGTCAGAGAA AACACTGGCT TCCTGCCATG ACATGAGATA CAGACAGGAG AGTTGGGAAG CTTTTTAAAG 001440
001441 ATGGCACTAT GACTACAATC ACAGAAACTC TCCATGAGGA AGTAAAAGAA AGCACCTGCA ACACTCCAGC TATGCAGACC 001520
001521 ACTCTGTAAT GGGCTCAGAT CTGGACAGGT GTGTGGAAAG GTGGGTCAAC AGGTCAGGCG TCACAGACTT GGAACATTCA 001600
001601 TGGTGGAAAA GAAAAAGCCC CAAAGAAGAG ACTTCAGGAT AAATGAGAAA ATACTCAAGA CAGCAAAAGT CTCTTTTAGA 001680
001681 AATGTTGGAG AAAGAACACT TAATGTCAGG AGTTACTGTT GATTGATGGC CTTACTGTGT AGCAGGTGAG AAACCCATTG 001760
001761 TTCAGTTCCC TAAAGTCACC CTATTCTCCC AATCATCCTA TGGAGGGGGA ACCATGATGG TTATCCCCAT CTTAT