Difference between revisions of "HSALNG0007045"

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(Created page with "''FALEC'', FAL1 is an oncogenic lncRNA that promotes cancer cell growth in part via repression of p21. ==Annotated Information== ===Approved Symbol=== ''FALEC'' ===Approved N...")
 
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===Characteristics===
 
===Characteristics===
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a lncRNA in a focal amplicon on chromosome 1q21.2
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''FALEC'' is a long noncoding RNA is located in a focal amplicon on chromosome 1q21.2. <ref name="ref1" />
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===Function===
 
===Function===
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''FALEC'' is associated with the epigenetic repressor BMI1 and regulates its stability in order to modulate the transcription of a number of genes including CDKN1A <ref name="ref1" />.
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FAL1 associates with the epigenetic repressor BMI1 and regulates its stability in order to modulate the transcription of a number of genes including CDKN1A
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The up-regulation of ''FALEC'' is connected with the poor prognosis of patients with melanoma <ref name="ref2" />.
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The up-regulation of FALEC is connected with the poor prognosis of patients with melanoma ref2
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FALEC could accelerate the proliferation of melanoma cells through influencing the cell cycle and apoptosis <ref name="ref1" />
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t FALEC could accelerate the proliferation of melanoma cells through influencing the cell cycle and apoptosis. ref2
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Knockdown of ''FALEC'' blocks the metastasis, invasion and EMT process <ref name="ref2" />.
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Knockdown of FALEC blocks the metastasis, invasion and EMT process ref2
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LncRNA ''FALEC'' is negatively correlated with p21 in melanoma tumorigenesis <ref name="ref2" />.
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LncRNA FALEC is negatively correlated with p21 in melanoma tumorigenesis re2
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''FALEC'' epigenetically silences p21 via binding to EZH2 <ref name="ref2" />
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FALEC epigenetically silences p21 via binding to EZH2 ref2
 
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===Regulation===
 
===Regulation===
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Please input regulation information here.
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===Diseases===
 
===Diseases===
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*Hepatocellular carcinoma ref3
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*Hepatocellular carcinoma <ref name="ref3" />
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*Ovarian carcinoma ref2
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*Ovarian carcinoma <ref name="ref2" />
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*Prostate cancer ref1
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*Prostate cancer <ref name="ref1" />
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*Thyroid cancer ref4
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*Thyroid cancer <ref name="ref4" />
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===Expression===
 
===Expression===
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FALEC is highly expressed in melanoma tissues and cell lines ref 2
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''FALEC'' is highly expressed in melanoma tissues and cell lines <ref name="ref2" />
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After stratifying the 128 late-stage ovarian cancer patients with ''FALEC'' RNA expression (cut-off, median expression) or gene amplification status, we found that both higher expression of ''FALEC'' RNA and genomic gain of ''FALEC'' gene were significantly associated with decreased survival in patients (p<0.0001 and p=0.03, respectively. <ref name="ref1" />
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After stratifying the 128 late-stage ovarian cancer patients with FAL1 RNA expression (cut-off, median expression) or gene amplification status, we found that both higher expression of FAL1 RNA and genomic gain of FAL1 gene were significantly associated with decreased survival in patients (p<0.0001 and p=0.03, respectively,
 
  
 
==Labs working on this lncRNA==
 
==Labs working on this lncRNA==
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==References==
 
==References==
 
<references>
 
<references>
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<ref name="ref1">  
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<ref name="ref1"> Hu X, Feng Y, Zhang D, et al. A functional genomic approach identifies FAL1 as an oncogenic long noncoding RNA that associates with BMI1 and represses p21 expression in cancer. Cancer Cell. 2014;26(3):344-357.
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A Functional genomic approach identifies FAL1 as an oncogenic long noncoding RNA that associates with BMI1 and represses p21 expression in human cancer
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</ref>(1)
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2014
 
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</ref>(1)
 
 
<ref name="ref2">  Ni NN, Song H, Wang XP, Xu XL, Jiang YQ & Sun JF. Up-regulation of long noncoding RNA FALEC predicts poor prognosis and promotes melanoma cell proliferation through epigenetically silencing p21[J]. Biomed Pharmacother. 2017, 96(1371-1379.
 
<ref name="ref2">  Ni NN, Song H, Wang XP, Xu XL, Jiang YQ & Sun JF. Up-regulation of long noncoding RNA FALEC predicts poor prognosis and promotes melanoma cell proliferation through epigenetically silencing p21[J]. Biomed Pharmacother. 2017, 96(1371-1379.
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</ref>(2)
 
</ref>(2)
 
<ref name="ref3">  Li BG, Mao R, Liu CF, Zhang WH, Tang Y & Guo Z. LncRNA FAL1 promotes cell proliferation and migration by acting as a CeRNA of miR-1236 in hepatocellular carcinoma cells[J]. Life Sci. 2018, 197(122-129.
 
<ref name="ref3">  Li BG, Mao R, Liu CF, Zhang WH, Tang Y & Guo Z. LncRNA FAL1 promotes cell proliferation and migration by acting as a CeRNA of miR-1236 in hepatocellular carcinoma cells[J]. Life Sci. 2018, 197(122-129.
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<ref name="ref4">  Jeong S, Lee J, Kim D, Seol MY, Lee WK, Jeong JJ et al. Relationship of Focally Amplified Long Noncoding on Chromosome 1 (FAL1) lncRNA with E2F Transcription Factors in Thyroid Cancer[J]. Medicine. 2016, 95(4).
 
<ref name="ref4">  Jeong S, Lee J, Kim D, Seol MY, Lee WK, Jeong JJ et al. Relationship of Focally Amplified Long Noncoding on Chromosome 1 (FAL1) lncRNA with E2F Transcription Factors in Thyroid Cancer[J]. Medicine. 2016, 95(4).
 
</ref>(4)
 
</ref>(4)
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<ref name="ref5">  Fromental-Ramain, C., Warot, X., Lakkaraju, S., Favier, B., Haack, H.,Birling, C., Dierich, A., Dolle, P. and Chambon, P. (1996a). Specific and redundant functions of the paralogous Hoxa-9 and Hoxd-9 genes in forelimb and axial skeleton patterning. Development 122,461 -472
 
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</ref>(10)
 
 
</references>
 
</references>
  
 
===Sequence===
 
===Sequence===
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>gi|100874054|ref|NR_051960.1| Homo sapiens focally amplified long non-coding RNA in epithelial cancer (FALEC), long non-coding RNA
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<dnaseq>GCGCATCTCCTACGGCCTCCAGGACAGAGGAACCGGGGGAGGCAGGGGGAAAAGGCCGGCCCAGCAATTC
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CCCTACCCCCCGGTCCCACGTGTACCCTCCTGGCCTGGGTCGCCCCAGCCCACGGGGAGCGGGCGGAGTC
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CTGGCCCACGAAGCCTTGTCACCTGGCGGGCGAATCCGCAAGCGGAGACTTGTCTTTAAAGGGCTTTGGG
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CCGGGCGCGGTGGCTCATGCCTGGAATCCCAGCACTTTGGGAGGCCGAGGCGGTGGATCACGAGGTCAGG
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AGTTCAAGACCAGCCTGGCCAAGAAGCTCATACTGACTAAGGCAGCAGAACATACAGGAGGAAGAGGAGC
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AGGTTTCACAGAGGGAAGACATGAGTTCAATTTTGGACTTCTCAGTAGTCGGTGTCCTCAGTGGTAGCAA
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CTTCAAACGGAAGGTGTCAAAAGTCAAATTCTGGAGAGTTGAGTATGAATGGGAGATGAAGAAAAGGAGG
 +
CAGCACTTGTAGCCTGCTCTTAATGTATTTCTGCACTCTACACTAGCAGCCTATTACACAGGACACTTGG
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ATGTCT</dnaseq>

Revision as of 04:48, 23 November 2018

FALEC, FAL1 is an oncogenic lncRNA that promotes cancer cell growth in part via repression of p21.

Annotated Information

Approved Symbol

FALEC

Approved Name

FALEC:focally amplified long non-coding RNA in epithelial cancer FAL1; ncRNA-a1; LINC00568

Characteristics

FALEC is a long noncoding RNA is located in a focal amplicon on chromosome 1q21.2. [1]

Function

FALEC is associated with the epigenetic repressor BMI1 and regulates its stability in order to modulate the transcription of a number of genes including CDKN1A [1]. The up-regulation of FALEC is connected with the poor prognosis of patients with melanoma [2]. FALEC could accelerate the proliferation of melanoma cells through influencing the cell cycle and apoptosis [1] Knockdown of FALEC blocks the metastasis, invasion and EMT process [2]. LncRNA FALEC is negatively correlated with p21 in melanoma tumorigenesis [2]. FALEC epigenetically silences p21 via binding to EZH2 [2]

Regulation

Please input regulation information here.

Diseases

  • Hepatocellular carcinoma [3]
  • Ovarian carcinoma [2]
  • Prostate cancer [1]
  • Thyroid cancer [4]

Expression

FALEC is highly expressed in melanoma tissues and cell lines [2] After stratifying the 128 late-stage ovarian cancer patients with FALEC RNA expression (cut-off, median expression) or gene amplification status, we found that both higher expression of FALEC RNA and genomic gain of FALEC gene were significantly associated with decreased survival in patients (p<0.0001 and p=0.03, respectively. [1]

Labs working on this lncRNA

  • Department of Pathology, Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, 210042, China
  • Ovarian Cancer Research Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
  • Center for Research on Reproduction & Women’s Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, USA
  • Department of Obstetrics and Gynecology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, USA

References

  1. ↑ 1.0 1.1 1.2 1.3 1.4 Hu X, Feng Y, Zhang D, et al. A functional genomic approach identifies FAL1 as an oncogenic long noncoding RNA that associates with BMI1 and represses p21 expression in cancer. Cancer Cell. 2014;26(3):344-357.
  2. ↑ 2.0 2.1 2.2 2.3 2.4 2.5 Ni NN, Song H, Wang XP, Xu XL, Jiang YQ & Sun JF. Up-regulation of long noncoding RNA FALEC predicts poor prognosis and promotes melanoma cell proliferation through epigenetically silencing p21[J]. Biomed Pharmacother. 2017, 96(1371-1379.
  3. ↑ Li BG, Mao R, Liu CF, Zhang WH, Tang Y & Guo Z. LncRNA FAL1 promotes cell proliferation and migration by acting as a CeRNA of miR-1236 in hepatocellular carcinoma cells[J]. Life Sci. 2018, 197(122-129.
  4. ↑ Jeong S, Lee J, Kim D, Seol MY, Lee WK, Jeong JJ et al. Relationship of Focally Amplified Long Noncoding on Chromosome 1 (FAL1) lncRNA with E2F Transcription Factors in Thyroid Cancer[J]. Medicine. 2016, 95(4).

Sequence

>gi|100874054|ref|NR_051960.1| Homo sapiens focally amplified long non-coding RNA in epithelial cancer (FALEC), long non-coding RNA

000001 GCGCATCTCC TACGGCCTCC AGGACAGAGG AACCGGGGGA GGCAGGGGGA AAAGGCCGGC CCAGCAATTC CCCTACCCCC 000080
000081 CGGTCCCACG TGTACCCTCC TGGCCTGGGT CGCCCCAGCC CACGGGGAGC GGGCGGAGTC CTGGCCCACG AAGCCTTGTC 000160
000161 ACCTGGCGGG CGAATCCGCA AGCGGAGACT TGTCTTTAAA GGGCTTTGGG CCGGGCGCGG TGGCTCATGC CTGGAATCCC 000240
000241 AGCACTTTGG GAGGCCGAGG CGGTGGATCA CGAGGTCAGG AGTTCAAGAC CAGCCTGGCC AAGAAGCTCA TACTGACTAA 000320
000321 GGCAGCAGAA CATACAGGAG GAAGAGGAGC AGGTTTCACA GAGGGAAGAC ATGAGTTCAA TTTTGGACTT CTCAGTAGTC 000400
000401 GGTGTCCTCA GTGGTAGCAA CTTCAAACGG AAGGTGTCAA AAGTCAAATT CTGGAGAGTT GAGTATGAAT GGGAGATGAA 000480
000481 GAAAAGGAGG CAGCACTTGT AGCCTGCTCT TAATGTATTT CTGCACTCTA CACTAGCAGC CTATTACACA GGACACTTGG 000560
000561 ATGTCT
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