Difference between revisions of "LINC00554"

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(Created page with "''LINC00554''is involved in a significant signal cascade which can be targetted for eliminating liver tumor-initiating cells (TICs). It is involved in self-renewal of TICs thr...")
 
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''LINC00554''is involved in a significant signal cascade which can be targetted for eliminating liver tumor-initiating cells (TICs). It is involved in self-renewal of TICs through protein kinase c substrates.  
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''LINC00554'' is involved in a significant signal cascade which can be targetted for eliminating liver tumor-initiating cells (TICs). It is involved in self-renewal of TICs through protein kinase C substrates ''MARCKS'' and ''MARCKSL1'' <ref name="ref1" />.  
  
 
==Annotated Information==
 
==Annotated Information==
 
===Name===
 
===Name===
 
''LINC00554'': long intergenic non-protein coding RNA 554(HGNC nomenclature). ''LINC00554''  is  located  near  from ''ZIC2'' locus.
 
''LINC00554'': long intergenic non-protein coding RNA 554(HGNC nomenclature). ''LINC00554''  is  located  near  from ''ZIC2'' locus.
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===Alias===
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lncZic2 <ref name="ref1" />
  
 
===Characteristics===
 
===Characteristics===
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===Function===
 
===Function===
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''LINC00554'' is required for the self-renewal of liver TICs in a ''ZIC2''-independent manner. ''LINC00554'' drives the expression of myristoylated alanine-rich protein kinase C substrate (''MARCKS'') and MARCKS-like 1 (''MARCKSL1''), whose expression levels are increased during liver tumorigenesis and liver TIC self-renewal. Mechanistically, ''LINC00554'' interacts with BRM/SWI2-related gene 1 (''BRG1'') and recruits this transcriptional regulator to the promoters of the ''MARCKS'' and ''MARCKSL1'' gene, which activates expression of these genes. Moreover, the depletion of ''LINC00554'' and ''BRG1'' decreases ''MARCKS'' and ''MARCKSL1'' expression and diminishes liver TIC levels <ref name="ref1" />. Findings suggest that the ''lncZic2-BRG1-MARCKS/MARCKSL1'' signaling cascade might be a potential target for eliminating liver TICs in the management of liver cancer <ref name="ref1" />.
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''LINC00554'' is required for the self-renewal of liver TICs in a ''ZIC2''-independent manner. ''LINC00554'' drives the expression of myristoylated alanine-rich protein kinase C substrate (''MARCKS'') and MARCKS-like 1 (''MARCKSL1''), whose expression levels are increased during liver tumorigenesis and liver TIC self-renewal. Mechanistically, ''LINC00554'' interacts with BRM/SWI2-related gene 1 (''BRG1'') and recruits this transcriptional regulator to the promoters of the ''MARCKS'' and ''MARCKSL1'' gene, which activates expression of these genes. Moreover, the depletion of ''LINC00554'' and ''BRG1'' decreases ''MARCKS'' and ''MARCKSL1'' expression and diminishes liver TIC levels <ref name="ref1" />. Findings suggest that the ''LINC00554-BRG1-MARCKS/MARCKSL1'' signaling cascade might be a potential target for eliminating liver TICs in the management of liver cancer <ref name="ref1" />.
  
 
===Regulation===
 
===Regulation===

Revision as of 07:47, 21 December 2018

LINC00554 is involved in a significant signal cascade which can be targetted for eliminating liver tumor-initiating cells (TICs). It is involved in self-renewal of TICs through protein kinase C substrates MARCKS and MARCKSL1 [1].

Annotated Information

Name

LINC00554: long intergenic non-protein coding RNA 554(HGNC nomenclature). LINC00554 is located near from ZIC2 locus.

Alias

lncZic2 [1]

Characteristics

LINC00554 has a chromosomal location of 13q32.3 (HGNC nomenclature).

Function

LINC00554 is required for the self-renewal of liver TICs in a ZIC2-independent manner. LINC00554 drives the expression of myristoylated alanine-rich protein kinase C substrate (MARCKS) and MARCKS-like 1 (MARCKSL1), whose expression levels are increased during liver tumorigenesis and liver TIC self-renewal. Mechanistically, LINC00554 interacts with BRM/SWI2-related gene 1 (BRG1) and recruits this transcriptional regulator to the promoters of the MARCKS and MARCKSL1 gene, which activates expression of these genes. Moreover, the depletion of LINC00554 and BRG1 decreases MARCKS and MARCKSL1 expression and diminishes liver TIC levels [1]. Findings suggest that the LINC00554-BRG1-MARCKS/MARCKSL1 signaling cascade might be a potential target for eliminating liver TICs in the management of liver cancer [1].

Regulation

NA

Diseases

  • Liver cancer [1]

Expression

LINC00554 and ZIC2 are both highly expressed in liver TIC, but LINC00554 doesn’t regulate ZIC2 expression [1].

Experiment Forward primer Reverse primer
NA NA NA

Labs working on this lncRNA

  • School of Life Sciences, Zhengzhou University, Zhengzhou 450001, China. [1]
  • Department of Pharmaceutical Engineering, School of Chemistry, Wuhan University of Technology, Wuhan 430070, China. [1]
  • School of Life Sciences, Zhengzhou University, Zhengzhou 450001, China. [1]
  • School of Life Sciences, Zhengzhou University, Zhengzhou 450001, China. [1]

References

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 1.9 Chen Z, Liu Y, Yao L, Guo S, Gao Y, Zhu P. The long noncoding RNA lncZic2 drives the self-renewal of liver tumor–initiating cells via the protein kinase C substrates MARCKS and MARCKSL1. Journal of Biological Chemistry. 2018, 293(21):7982-92.

Sequence

>gi|100861542|ref|NR_047483.1| Homo sapiens long intergenic non-protein coding RNA 554 (LINC00554), long non-coding RNA

000001 GGTAGCAGGC GGAAGTGCGG CCCTCGAGGC GGTCGCGGCC TGTCGGGGCT TGGAGCGAAT GGCTCCAAGG CCGCAGGCTG 000080
000081 GGCCTGGGCC GCAGCCGTGG GAAGCCGACG ATGCCTGAGG CGCTCTGTCC TCGGCCCACC CTAGGAACTT GTATGACCGC 000160
000161 AGGAAAGGAT CAGGAGAGGC CGCTGCCCGT CTCCCACCGG CTCTAGGCTC CCTCGGCCGA CCGATGTGGG GAAGGGGAAG 000240
000241 GGGCCCGCGC CGAGGCTCTA GGGGAGGCTC CTAGGCCGGG TTCTCTGACT TAAGGCCCTC TTGGCTGTGG TTTTGCGGGA 000320
000321 GTGAGTTGAG GGAGCTGCAT TCACTCAAGT CCCTCACATG CCCGAGGGCC CGGGAATCGT GAAGCCGGGC CTGCGGACCC 000400
000401 GGTGGGAGGA AGGAGTGCGA AGCGCGGCCG CCGTGCTCGG CCGGCGCCGG GCTAGGTCGG GCGGTGGGGA CCGCGCCGGC 000480
000481 ATAGGACAAC GCGGTGGAGG GAAGCACCTG CCCCCGCCCA CCTTGACTCA GGGCCGCCGC GCCCCTCCTG GGCCATCCGC 000560
000561 GCGGGGGTCT CAGGATGGCG AAACCCGGGA CCTCGCGGCC CTCTAGTGCT CCCCTGCCAG GGTGCGACCT AGGTACCCTT 000640
000641 TATCGAGCCC CACTCCCCAA GGCAGAGAGA GTTCGACGTT CCCAAGGAGG GAGTCTCCAT GGAGGAATTC GTCCTGCTTC 000720
000721 ACTTCCAGAG TTGAAAGCCC GTCGGTTCTG CAAAGAGGAG CAGTCGGGCG CGGGCTAGCA AGCAGCTGAT GAAAATAATT 000800
000801 GTCCTCGCAC ACACAGCCCT GCGCCCAGGG GCGCGCGCGC GCACACACAC ACACACACAC ACACACACAC ACACACACAC 000880
000881 AACTTGCCTC CTCTAGCCGC CCAACCTTAA TATTCCGGGC ATGCAGTTTT CAACAACTTG CCTGACACAA TAACAAAGAC 000960
000961 ATTTAAATGC CAGGACGCAG ACTTCACTTT TTAACCTGCT GAGAGGAGCT ACTTTCAAAG CTTCCCCACC GCGAATAAAC 001040
001041 TGACAAAAAA TATGGGGTGC ACTTATAAAT TAAACACCTT ACCCTCAAAG CAATATACGT TAATCAGGTT TCTAAGGCAA 001120
001121 TAGCCATCTC TGTCTTTTCC TATTCACCCA AATAATGCCC CCAGAAGGAA CCCCTTTACA CAAGAGAGAA CTGGAAAAAA 001200
001201 AATGAATTAT ACCCATTGCT AGTAAAAAAT CATCTTAAAT CAATAGAGCA CCACTTGAAC TTGAGTTTCT ATTGTTTCAC 001280
001281 TGAATCATCA ATGTTTTTAA TTAAACAGAG CTACCCTTTC TGTTAAAACA TTACATAAAA GGGTTAGGTT TCTACTTTTG 001360
001361 TTGAGGCAGC TGGCGTTTGT TGGCTGTTGT GTTTGAGCAA CAGACTGTTC AATGGAAGCG AGAAATAGCT CAACGCGCTC 001440
001441 TTAATAGACC TGTTTCAACA ATGTATCTTG AAAAGGAATA CATTGTGTTA TTGTGTTAGT TTGCTACAAA CCTATTAAAA 001520
001521 GAAAAATAGC ATCCATCAGG TCTAACAAGA CGCATTTGTA TTATACGTAC TTATCTGCTT CAAATACACT TCTTGGCACA 001600
001601 ATGTCTAGAA TTCAACTAGA TCATCAGGAG CTGGGCAGAA GAACGCATAC CAGTTAGGTA ATGATACACG GGCTAAAAAT 001680
001681 AATAATAAAG GAAGGACTAA GCAGACGGTA ATTGCTACTT TTTTGTGTAT CATGAGAAAT AACAGGCAAC CCTACTTCAA 001760
001761 TTAAAAATAT ATTGCAAAAG TGTGGACTCC TACGACAAAA ACAATTTAAA AAATATTTGT AGCATGGGAA TATTGATCCA 001840
001841 TATCCCATAT TTGGAACGAA TCTGATACAC TTTCGATAGG AATTTGTTTC AGAGAAGGAT TCAGGGCAGA AGCGATGCAT 001920
001921 TTTTAAAGC