EPB41L4A-DT

EPB41L4A-DT, is a long noncoding RNA act as a tumor suppressor in mediating the proliferation of solid tumors.

Annotated Information

Name

Approved symbol:EPB41L4A-DT

Approved name:EPB41L4A divergent transcript

HGNC ID HGNC:25643

Previous names:EPB41L4A antisense RNA 2 (head to head)

Alias symbols:FLJ11235

RefSeq ID:NR_027706

prev_symbol:EPB41L4A-AS2

Characteristics

EPB41L4A-DT is one exon transcript of 1406 bp long non-coding RNA, located on human chromosome chr5q22.2 .

Function

Ectopic overexpression of EPB41L4A-DT inhibits tumor cell proliferation. (A) Endogenous expression of EPB41L4A-DT was detected in breast cancer cell lines. (B) Validation of ectopic overexpression of EPB41L4A-DT by qRT-PCR. Ectopic overexpression of EPB41L4A-DT inhibits proliferation (C), promotes apoptosis (D) and decreases colony formation (E) in MDA-MB-231, A549 and 786-O cell lines. qRT-PCR amplification was performed in triplicate and the levels of EPB41L4A-DT were normalized against control GAPDH expression. Data are presented as the mean value from three independent experiments ± S.D. ***p < 0. 001; **p < 0. 01; *p < 0.05.

The expression of EPB41L4A-DT in high-staged tumors was downregulated compared with those with low tumor stage in lung and renal cancers. Aberrant expression of EPB41L4A-DT in tumor tissues indicate that it serves as a tumor suppressor and that its downregulation contributes to tumorigenesis and disease progression. Overexpression of EPB41L4A-DT inhibited tumor cell proliferation in breast, renal, and lung cancer cell lines. .

Expression

EPB41L4A-DT is downregulated in breast, renal cancer and lung cancer tissues compared with normal tissues .

Regulation

Please input information here.

Diseases

• Breast cancer
• Lung cancer
• Renal cancer

Labs working on this lncRNA

• Department of Breast Surgery, Harbin Medical University Cancer Hospital, Harbin, China.
• Department of Pathology, Harbin Medical University Cancer Hospital, Harbin, China.
• Biotherapy Center, Harbin Medical University Cancer Hospital, Harbin, China.
• Heilongjiang Academy of Medical Sciences, Harbin, China.

References

Sequence

>gi|54508|ref|NR_027706.1| Homo sapiens EPB41L4A divergent transcript (EPB41L4A-DT), long non-coding RNA

000001 TCAGATCCGC CGAGTATGAA GCGCTCGGCT TTTCTTTTGT GTGAGGAGCA CCCACGACGC CCCGACCATG GGCGCAGGGG 000080
000081 CAGAGGCGAA GGTCGTCGCT CCGTCCGCTA CCCCGTCCCC CAGCCGCAAG CGCCGAGGAG CCGGAAGAGA GGCGGAAAGG 000160
000161 GCAGCAGGCT CCTTACCCAG ACCAGCGAGG GGAGGTCAGC TCGTCGCGGG GTGTGGCTCC CGTCCGGGGA CTCCCGAGCT 000240
000241 CATTACGGGT GGCCGTGTGT AGCCAAGTTC AAGCTCTCCC TCCGGGAATG CCTGCCGCGG CGGCGGAATA CGGCTTCTTC 000320
000321 AGGACATTCA GCAAAGCGGG GAGGCGGGGA CCTGCGGGCG GAGGAGCGAC GCCCCAGCTG GGAACGCGGC GGACGGGCGA 000400
000401 GCGGGGGGTG CGCCCTGGGC GCGCCAGGCC GCAGAGGCTC CGGGGAAAGT TCTCTTGGCC GCGCGAGTGG TGGCGCCCCG 000480
000481 GGCGGGAGCA GCCCAGGTGC ATGTGGGCCC GGTCCAGGCG TCTGCAAAAA GCCCTGGAAC GAAGCGGACC CCCCAGTCCA 000560
000561 GCGCTGGCCG CGGCAGGGGA GCCCCTTCTG GGCGGGGTAT CAGCTGGGGG CGGAGGGCGG GGCAGAGACC GTGGTCCCAG 000640
000641 CGGCGAGGTG CCGGCGAGTC CACGCTGCCA AGCCGCACAC TGCGCCCAAG CCGCGGGGCA GTCCAGCGCT CGCTGCGTCC 000720
000721 TTCCCCCGAG AGACCTGGAG GCTGGGTGGG GAGAAGAGGA CGCGGTGCTG CTCGGACCCC ACGGTTCGGC GGTCCCAATC 000800
000801 CCACGCCCTC CGCGCGGTCG GCCGCGTCCA GGACTGAGGG GCACAATAGC TCTGAAGCTG CAGTGACCCC TGGTGGGTCC 000880
000881 CGATGTCCGT GCACAGGCAG CCGAGGTTGA GCTGCGGACG ACACTGAGCC CCGCTGGGCT TCGGAGCAGG TGCAATCTGT 000960
000961 GCTCTCCAGC TGGGAACCAG CAGCGAGTTA ATGCGAGTCG CAGTTAGGGG AGACACGAGG GGAGGTGTCA CAGAAAAAAA 001040
001041 ACTCTATATT GAGTTTTAGA GTTAGAGCTT TGGCATCAGA CGTAGTTTTG AGTTGACTAT TCTACTGCTT GTTAGCTGGG 001120
001121 TAGCCAAAGC TCAAAAAAAA TTGCTTAAAA CCTAGGACGT TAGCCCTTAA AACAAAACCA GGCTTCCGTA GCACAGTAGA 001200
001201 AATGAAATGA ACAATTGGCG ACTTTTGATG GAGTTTCCTC TCATAGTGAT TTGCCACAAA GGACCTTCTG TAGGAAGCCT 001280
001281 CGGCCTTCCC TGCTATTGTG ACCCCATCCA AACACAGGAT CAGCATAACC GCCAAAGTGC AATATAAATT TCTGAACTTT 001360
001361 ACCTAGGCTA TGAATAAAAC TATTTTATCT TCTGAAAAAA AAAAAA