Difference between revisions of "SNHG14"
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The mechanism of epigenetic silencing of UBE3A has been associated with a brain specific paternal antisense (UBE3A-ATS) transcript in human and mouse<ref name="ref1" />. | The mechanism of epigenetic silencing of UBE3A has been associated with a brain specific paternal antisense (UBE3A-ATS) transcript in human and mouse<ref name="ref1" />. | ||
Revision as of 11:20, 11 August 2019
Contents
Annotated Information
Name
Approved symbol: SNHG14
Approved name: small nucleolar RNA host gene 14
HGNC ID: HGNC:37462
Previous names: UBE3A antisense RNA 1 (non-protein coding); small nucleolar RNA host gene 14 (non-protein coding)
Previous symbols: UBE3A-AS1
Alias symbols: NCRNA00214; UBE3A-AS; UBE3A-ATS
Alias names: non-protein coding RNA 214; UBE3A antisense
RefSeq ID: NR_146177
LncBook ID: HSALNT0217643
Characteristics
Human UBE3A-ATS is a large (∼460 kb) transcript that initiates in the PWS-IC and extends distally through SNURF/SNRPN, IPW and overlaps UBE3A, alternatively spliced and serves as a host for several types of small nucleolar RNA (snoRNA) of the box C/D class that are contained within the introns and are expressed upon processing of the paternal copy of the host transcript[1].
Expression
More distal part of UBE3A-ATS, which overlaps UBE3A, is brain specific[1].
Regulation
In the 7SK ribonucleoprotein, Larp7 binds directly to 3′ terminus of 7SK RNA ((Krueger 2008)) ((Markert 2008)), and prevents degradation of 7SK in vivo ((Krueger 2008)).
Function
The mechanism of epigenetic silencing of UBE3A has been associated with a brain specific paternal antisense (UBE3A-ATS) transcript in human and mouse[1].
Disease
Angelman syndrome (AS)[1]
Evolution
Please input evolution information here.
Labs working on this lncRNA
- Department of Genetics and Developmental Biology, University of Connecticut Health Center, Farmington, CT 06030, USA.
