Difference between revisions of "FAM201A"

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===Regulation===
 
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===Function===
 
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[[File:Model of hLarp7 recognition of the 7SK.png|right|thumb|Model of hLarp7 recognition of the 7SK 3′end and mechanism of assembly of core 7SK RNP([https://www.ncbi.nlm.nih.gov/pubmed/29946027 (Eichhorn 2018)])]]
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FAM201A contributed to radioresistance by upregulating ataxia telangiectasia mutated (ATM) and mammalian target of rapamycin (mTOR) expression via actions as a miR-101 sponge, lncRNA-FAM201A may also modulate cell ionizing radiosensitivity via a “FAM201A-miR-101-mTOR-NHEJ” axis, may be a potential biomarker for predicting radiosensitivity and patient prognosis, and may be a therapeutic target for enhancing cancer radiosensitivity in ESCC.<ref name="ref1" />.
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FAM201A contributed to radioresistance by upregulating ataxia telangiectasia mutated (ATM) and mammalian target of rapamycin (mTOR) expression via actions as a miR-101 sponge， may be a potential biomarker for predicting radiosensitivity and patient prognosis, and may be a therapeutic target for enhancing cancer radiosensitivity in ESCC.<ref name="ref1" />.
 
  
 
===Disease===
 
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==Labs working on this lncRNA==
 
==Labs working on this lncRNA==
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* Department of Radiation Oncology, Fujian Medical University Union Hospital and Fujian Provincial Platform for Medical Laboratory Research of First Affiliated Hospital, Fujian, China<ref name="ref1" />.
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* Department of Radiation Oncology, The Second Affiliated Hospital of Soochow University, Suzhou, China<ref name="ref1" />.
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* Laboratory of Molecular and Genetic Information, Institute of Molecular and Cellular Bioscience, The University of Tokyo, Tokyo, Japan<ref name="ref3" />.
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* Department of Orthopaedics, Huashan Hospital, Fudan University, Shanghai 200040, China<ref name="ref4" />.
  
 
==References==
 
==References==

Latest revision as of 14:28, 11 August 2019

Annotated Information

Name

Approved symbol: FAM201A

Approved name: family with sequence similarity 201 member A

HGNC ID: HGNC:27239

Previous symbols: C9orf122

Previous names: chromosome 9 open reading frame 122; family with sequence similarity 201, member A

RefSeq ID: NR_027294

Ensembl ID: ENSG00000204860

LncBook ID: HSALNT0288968

Chromosome

9p12

Characteristics

Overexpression of lncRNA FAM201A is highly correlated with the radiosensitivity of ESCC and is associated with poor surviva[1].l

The FAM201A gene is a 2.9 Kbp long gene located in genomic 9p13.1, that results in RNA transcripts without ORFs, which means that it has no protein-coding potential.

Expression

FAM201A was upregulated in radioresistant ESCC tumor tissues[1].

Regulation

Please input regulation information here.

Function

FAM201A contributed to radioresistance by upregulating ataxia telangiectasia mutated (ATM) and mammalian target of rapamycin (mTOR) expression via actions as a miR-101 sponge, lncRNA-FAM201A may also modulate cell ionizing radiosensitivity via a “FAM201A-miR-101-mTOR-NHEJ” axis, may be a potential biomarker for predicting radiosensitivity and patient prognosis, and may be a therapeutic target for enhancing cancer radiosensitivity in ESCC.[1].

Disease

  • colon adenocarcinoma [1]
  • Obsessive-compulsive disorder[2]
  • Tourette's syndrome[2]
  • colorectal[3]
  • Osteonecrosis of the femoral head[4]

Evolution

Please input evolution information here.

Labs working on this lncRNA

  • Department of Radiation Oncology, Fujian Medical University Union Hospital and Fujian Provincial Platform for Medical Laboratory Research of First Affiliated Hospital, Fujian, China[1].
  • Department of Radiation Oncology, The Second Affiliated Hospital of Soochow University, Suzhou, China[1].
  • Laboratory of Molecular and Genetic Information, Institute of Molecular and Cellular Bioscience, The University of Tokyo, Tokyo, Japan[3].
  • Department of Orthopaedics, Huashan Hospital, Fudan University, Shanghai 200040, China[4].

References

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Shahriyari L. Effect of normalization methods on the performance of supervised learning algorithms applied to HTSeq-FPKM-UQ data sets: 7SK RNA expression as a predictor of survival in patients with colon adenocarcinoma. Brief Bioinform. 2017 Nov 3. doi: 10.1093/bib/bbx153.
  2. ↑ 2.0 2.1 Yu D, Mathews CA, Scharf JM, et al. Cross-disorder genome-wide analyses suggest a complex genetic relationship between Tourette's syndrome and OCD[J]. Am J Psychiatry, 2015, 172: 82-93.
  3. ↑ 3.0 3.1 Matsumura K, Kawasaki Y, Miyamoto M, et al. The novel G-quadruplex-containing long non-coding RNA GSEC antagonizes DHX36 and modulates colon cancer cell migration[J]. Oncogene, 2017, 36: 1191-1199.
  4. ↑ 4.0 4.1 Huang G, Zhao G, Xia J, et al. FGF2 and FAM201A affect the development of osteonecrosis of the femoral head after femoral neck fracture[J]. Gene, 2018, 652: 39-47.

Annotation originally sourced from lncRNAdb.

Sequence

>gi|224591428|ref|NR_027294.1| Homo sapiens family with sequence similarity 201 member A (FAM201A), long non-coding RNA

000001 GAGTGCACCT GGCCTGAGAG CCCGCCAGGC CCTGCCCCTG CTCGGCTCCT CGTCTGCTGA AGCTCGGGAC CTCTAGCCAG 000080
000081 TGGCCCTCTG CAGCCACGGG GAATGGGGCT GAGAGCCGGT TCCCGCTGCA GGGCAGACCA CCTAGCTCAG CCGCAGCCAC 000160
000161 AGGGACATCT GGCCCCGGTT CTGAGATGTG GGGAGTGCTG GCGGGCTCGG GGGTTGCCTG GAGGCTGCTG CCTGCACACA 000240
000241 GAAGGCGGAT GCAGCTTGGG TGCCCAGGCG GGCTGGAGGA CAGCGGGCTG GGAAGCCAGG GGCCGCCGGG ACCTGGGGCT 000320
000321 GGAAACCACA TCTGCCCACA GCCGCAGCCT CCTGCACCTG TCATCCTGGC GGCGCCCTGA CGTCGGAGAA GCAGCAGGCG 000400
000401 CGGAGCTCCT GCAGCGGGCA CCGCTGCAGC AACCCGACCC GGCGCAGGCG GCAGTGGAAG GCGGCCTGCT AGCACGGCTC 000480
000481 CCGCGGCCCC AGGACCAGGG GTGCGGCCAG CACCGCCCTC ACTCCCCGCG TCTCGTGGAT ATTGCCCTCC CTGGAGGCGG 000560
000561 CTGGACCTAA GCGAGGCTCG CAGCGATCGG CCCCGCGAAG ACTCGCATGC AGGGCTCAGG ATCCCGCATT CTGGCGCCGC 000640
000641 GGCACCGCAC CTTTCAGCAG CCCTGCTCCT CTTCTTGTTG GTAAACTTTT GTCACTCTGC CATGAAAAGC ATCCAGGCGT 000720
000721 CCTTGATTTC GACATTGCGT GCACGCTCAG CCGAGCTCAT CAGACGGGCG GTTGTCCCCA GAGCCCGCGG GTAGCTTGTT 000800
000801 CCCGGGCGGC GGCTCCTGCT GGATGCAGCT CCTTGTGGGC CTACCAGGCT TGGTGGAGCC ACAGCAGACC TGTGGAGAGG 000880
000881 AAGAGTAAGG CGGGCTCTGC AGGGCAGTGG GCCGGGACCA TGAGAGAGGC GGGTCAGTCT GGGCTCCAAG CTCAGCCTCT 000960
000961 CGGATTCCCC GGGACCCACG GCTTATAATG CGCTTAAATC CCACGCCTCG CCCGAGAGAC AGCACGTCAC CGTCACCGTC 001040
001041 ACCGCCTAGC GCCCCTGACC CGCTCCCACT CCGCTGCAGC GGAGGGTGTG TGAGGGAGAG GGACGCAGGG AGGGAAAAGC 001120
001121 GTTGGGAGGG CAAACATCTT TTCATAAGCT TTTCCCCTTC TATATGCCAT CTCTGATGGG AGCCTCTTTA GATCTTTCGT 001200
001201 CCATTTACTA ATTGGGTTGT TCGATTTCTT ATTGTTGAGT TGTAAGTGGT TTTTAATGGT CTGGATGCCA GACAGGTGTT 001280
001281 TTGCAAATAT TTTCTCCGTC TGTGGCTTGT TTCTCCATTC TCTTATTTCC TTTCCCAGAG CAAAAGTTTT TAATTGTAAC 001360
001361 GACTTCATAC CAATATCTTC TTTCATGGTA GAAATTTGTC TTTTATGTAC TTTACTGTTG TATCTACAAA GTAATTGCCA 001440
001441 AACCCAAAGT TACCTAAATA TCCCTTTTGT TATTTTACAG AAGTTTTACA GCTTTTGGAT TTAAATTTAG GTCTAAAAAT 001520
001521 TGAATTCATA AAAGTAGAGA GTATAATGAT GCTTACCAGA GGCTGTGTTG CTGGGGAGAA AAATGGGAAG TTGTTCACAG 001600
001601 ATGCAAAGAT TCAGTTAAAC CGGAGAAATG CGTTTTGAAA TCTATTGCAC AGCAGGATGA CTATAGTCAA TAATAATGTA 001680
001681 CTGTATATTT AAATAACAAA AAGTAAATTT CAAATATCTA ACCACAAAAA AAAAAAAAAA A

Predicted Small Protein

Name FAM201A_smProtein_185:379
Length 64
Molecular weight 6456.4265
Aromaticity 0.03125
Instability index 83.928125
Isoelectric point 9.00665283203
Runs 9
Runs residual 0.00796875
Runs probability 0.0270073995564
Amino acid sequence MWGVLAGSGVAWRLLPAHRRRMQLGCPGGLEDSGLGSQGPPGPGAGNHICPQPQPPAPVI
LAAP
Secondary structure LEEEELLLLHHHHLLHHHHHHHLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLEE
EELL
PRMN -
PiMo -
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