Difference between revisions of "NR2F1-AS1"

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===Chromosome===
 
===Chromosome===
 
5q15
 
5q15
 +
 +
===Expression===
 +
lncRNA NR2F1-AS1 is up-regulated in oxaliplatin-resistant hepatocellular carcinoma (HCC) tissue.<ref name="ref1" />
 +
 +
===Function===
 +
In vitro,NR2F1-AS1 knockdown reduced the invasion, migration, drug-resistant gene (MDR1, MRP5, LRP1) and IC50 value in Huh7/OXA and HepG2/OXA cells. In vivo, NR2F1‐AS1 knockdown decreased the tumour weight of HCC cells.<ref name="ref1" />
 +
Bioinformatics tools and luciferase reporter assay confirmed that NR2F1-AS1 regulates hepatocellular carcinoma (HCC) oxaliplatin resistance through targeting miR-363-ABCC1 pathway. <ref name="ref1" />
  
 
===Sequence===
 
===Sequence===
 
>gi|565671824|ref|NR_021490.2| Homo sapiens NR2F1 antisense RNA 1 (NR2F1-AS1), transcript variant 3, long non-coding RNA
 
>gi|565671824|ref|NR_021490.2| Homo sapiens NR2F1 antisense RNA 1 (NR2F1-AS1), transcript variant 3, long non-coding RNA
 
<dnaseq>GGCGCGGAGCCGCGCGGAGTGACAAAGCCGCCGCTGCCGCCGCCGGGGGTGGGAGCCGCGCTCGCCCGCCCGCCCCTCGACTCGCGAGGGCGTAAAAGTTTGTCTCAGCTCGAGCATTCCTAGCGCCAACACGCCCTCAGGTAAAGGTGGAAGTAAATGGCCACGCTGTATTGACAGAGCAGGTAGATGAAACTCAAGAGAAAAGGTGTGGATAAATGAAACTAGCCCATGATGAACCTGTTTTCTCCGTGACCACAATATTAACCAGGATGAATGGCGGTGGCAGTGGGCCTGCATCACAGGTTGCAGCAGATGTTCTCAATATTTCTATTAAAATTTCCTTATTTCCATATGCAAGAGGAGCCCCAGAGCTGCATCCTTATGGTAGCTACCATGCCGTGATGTAAGCTGCCATTCACTGGGGAGCTTTGGCAATAGAATTGGCTAGATCAGGAAGCCTATGTCAACTATGGAACAACAACTTGCAGCTCATCTCTATTGATGATGGAATCTCGCTATGTCACCAGGCTGGAGTGCAGTGGCGCAACCTCGGCTCAGCGCAACATCCGCCTCCCGGGTTCAAGTGATTCTCCTACCTCAGCCTCCTGAGTAGCTGGGATTACAGGAATCTAATGACCATTGAACTGTGGCCATGACTTCAATTACAAGTATTTTCTTCACTAATGTCAGACTGTGGGCCTTTGTATATACACTTTTAACAAACTTTTTGGAAGTGCAATACATATCGCAACAACTTCTCAATGCTGAATCATAGTATTGGAAGACATTTTAAGCAACAATTAAACTCAACTTATTTACTACCAATAATGTACATAAGTCAGCTGAAGTGAGGATAACATGAATAGCACAAATACATTATGATTGCTGCCTGGCCAACAGTAATTATAAGAAACTGTCAGTTTTGAGATGTGTCTTGATTTCAGAGATGTTAAAAAAGTTTGTAAGTTACCATTGATAAAATATGAGTTTGCTTCCACAAATATTCTTTCTTCTGTCCTTCTGGAACTCAAGAGTAAACATATATTAGATTTTCTCACCATTTCATGCATGCTGGTTCCTAGGCTACTCTCTGAGTCATTTTTTTTTTCTTATCTGCCCTCCAGTTCACTAGTTCTGTCATTTTCTGGGTCTGATCTGCTGCAAATGCAATACATTGAGTTTTAAATTTCAGTCATTGTGTTTTCATTTCTAGAAATTTCATTTGACTCTTTCTCAAATTACTTTTCCATTTTTTTTGTAGTTTCCTATCCCTGGAGATATTTTCAATCATGCCATTTAATTTTTTAAATACGCAAGTGTAGTTTTATAATTTGTGTCTGATAATTCTAATATCTGAAGTCTTAGTAGGTCTGTTTCAGTTGTCCTGTAATTATGCATGTTTTTGCCCATGTTGCTTTGTTTCCTTGTATGCTTGGTTATCTTTCTTACTGCCCTTGCAAAATTATTTGGAGAGTCCTGGAGGCTTAAATGAAGATAACTTTTAGGAATAATTTGCATTTGCTTTTGCCGAGGATCTTGGGATCATTTCAACCAAAATCTTAGCTTGAAATTCCGCAATCAATCAAGGTGATGAGAACCTGGTCAGTAAATCCTAATGAGGGCCAGGCTGTGGCCAAAGATTTTTAGACAGATGTTTCCCTCCTTTGCCATTTCTCTTTTCTTTCCTCCTCTGCTCCTCTTAGTGTCCAGACAACCTTCATGGAAGTCCTTGGGGTGGGTGGGAAATGAGGACGGCAGGTTTCATTCTAGGTATAGCCCTTTGAGGTCTAACTTAATGCAGAGAGAGTTTTCTGGTCTATGTGCCACCTTACATGGGATCTTGAGCCTTGATTTCTAAACCCCTTGCCTTTGATGTTTCAGAATTGAAGCTTAAATTTGCCAACAGGCAAATGTCCTCAAGGCAAATTGGCTTAGGTGTTCGATATTCTTCTTACCAGAAAGGTAAACTTGGGTTTTTTACTTCACCCAGGATTTGGCATGACAGTTCCCCATTATCTTGTCAGCTTAGTGCTTTAAGTGATTGCATTTAAAAAAATTCTGCATTTTCAGTTTTTAGCAGGAGGAATGGCCTCAACTAGTGGTTTTCAACTGGGGATGATTTTTTTCCCCTAGGGGACATTTGATAATGTTTGGAGATGTTTTAGTTGTTAGAACTGGGGTTGGGGGAACTACTGTCATCTGGTGGGGAGAGACCGGCAATGCTGTTGATCTTACTATAATGCACAGGCCACCCCCAACAACAAACAAATTACATAGCCCCAAATATCAATAATGCCAAGGTCCAAATAACCTAACCTTCCATTACTGAAAATAGAAGTTCAAGAAGATAGTTTATAATTTAAAAATTTTTAGGTCTTAATAAGTTGTCATACTTTCACAGGTTTTATTTCATACTAAGTAATTTATTTCAAATTTTACATTCCAATTACAGAAAATTTTCTAAGCCAGTTTTTGTTCTTCATGAGTATTACTATCAAGGTCACATTTTTCATCTAGTATGTTTTACCCTGGTACTTGTTGGCAGGGTCAGGACTAAGGTGAGATGCGCAAGGCATTTGCCTCACACAAAATGCACAATGAATAAAATGTCAAAACTTTAAATAAAGACAGAATCACTAAAAGTACTTTGCCATATTGGAACCTGAGGCAAAAAGAAAAATAAGTAATAATATTTAAAATTTTGATCTCTTGTTCATTGTAGATTTTTACATTAATTTTGATTGTTTAAAACATTGCATTAAAATATTATTTAATGTGAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA</dnaseq>
 
<dnaseq>GGCGCGGAGCCGCGCGGAGTGACAAAGCCGCCGCTGCCGCCGCCGGGGGTGGGAGCCGCGCTCGCCCGCCCGCCCCTCGACTCGCGAGGGCGTAAAAGTTTGTCTCAGCTCGAGCATTCCTAGCGCCAACACGCCCTCAGGTAAAGGTGGAAGTAAATGGCCACGCTGTATTGACAGAGCAGGTAGATGAAACTCAAGAGAAAAGGTGTGGATAAATGAAACTAGCCCATGATGAACCTGTTTTCTCCGTGACCACAATATTAACCAGGATGAATGGCGGTGGCAGTGGGCCTGCATCACAGGTTGCAGCAGATGTTCTCAATATTTCTATTAAAATTTCCTTATTTCCATATGCAAGAGGAGCCCCAGAGCTGCATCCTTATGGTAGCTACCATGCCGTGATGTAAGCTGCCATTCACTGGGGAGCTTTGGCAATAGAATTGGCTAGATCAGGAAGCCTATGTCAACTATGGAACAACAACTTGCAGCTCATCTCTATTGATGATGGAATCTCGCTATGTCACCAGGCTGGAGTGCAGTGGCGCAACCTCGGCTCAGCGCAACATCCGCCTCCCGGGTTCAAGTGATTCTCCTACCTCAGCCTCCTGAGTAGCTGGGATTACAGGAATCTAATGACCATTGAACTGTGGCCATGACTTCAATTACAAGTATTTTCTTCACTAATGTCAGACTGTGGGCCTTTGTATATACACTTTTAACAAACTTTTTGGAAGTGCAATACATATCGCAACAACTTCTCAATGCTGAATCATAGTATTGGAAGACATTTTAAGCAACAATTAAACTCAACTTATTTACTACCAATAATGTACATAAGTCAGCTGAAGTGAGGATAACATGAATAGCACAAATACATTATGATTGCTGCCTGGCCAACAGTAATTATAAGAAACTGTCAGTTTTGAGATGTGTCTTGATTTCAGAGATGTTAAAAAAGTTTGTAAGTTACCATTGATAAAATATGAGTTTGCTTCCACAAATATTCTTTCTTCTGTCCTTCTGGAACTCAAGAGTAAACATATATTAGATTTTCTCACCATTTCATGCATGCTGGTTCCTAGGCTACTCTCTGAGTCATTTTTTTTTTCTTATCTGCCCTCCAGTTCACTAGTTCTGTCATTTTCTGGGTCTGATCTGCTGCAAATGCAATACATTGAGTTTTAAATTTCAGTCATTGTGTTTTCATTTCTAGAAATTTCATTTGACTCTTTCTCAAATTACTTTTCCATTTTTTTTGTAGTTTCCTATCCCTGGAGATATTTTCAATCATGCCATTTAATTTTTTAAATACGCAAGTGTAGTTTTATAATTTGTGTCTGATAATTCTAATATCTGAAGTCTTAGTAGGTCTGTTTCAGTTGTCCTGTAATTATGCATGTTTTTGCCCATGTTGCTTTGTTTCCTTGTATGCTTGGTTATCTTTCTTACTGCCCTTGCAAAATTATTTGGAGAGTCCTGGAGGCTTAAATGAAGATAACTTTTAGGAATAATTTGCATTTGCTTTTGCCGAGGATCTTGGGATCATTTCAACCAAAATCTTAGCTTGAAATTCCGCAATCAATCAAGGTGATGAGAACCTGGTCAGTAAATCCTAATGAGGGCCAGGCTGTGGCCAAAGATTTTTAGACAGATGTTTCCCTCCTTTGCCATTTCTCTTTTCTTTCCTCCTCTGCTCCTCTTAGTGTCCAGACAACCTTCATGGAAGTCCTTGGGGTGGGTGGGAAATGAGGACGGCAGGTTTCATTCTAGGTATAGCCCTTTGAGGTCTAACTTAATGCAGAGAGAGTTTTCTGGTCTATGTGCCACCTTACATGGGATCTTGAGCCTTGATTTCTAAACCCCTTGCCTTTGATGTTTCAGAATTGAAGCTTAAATTTGCCAACAGGCAAATGTCCTCAAGGCAAATTGGCTTAGGTGTTCGATATTCTTCTTACCAGAAAGGTAAACTTGGGTTTTTTACTTCACCCAGGATTTGGCATGACAGTTCCCCATTATCTTGTCAGCTTAGTGCTTTAAGTGATTGCATTTAAAAAAATTCTGCATTTTCAGTTTTTAGCAGGAGGAATGGCCTCAACTAGTGGTTTTCAACTGGGGATGATTTTTTTCCCCTAGGGGACATTTGATAATGTTTGGAGATGTTTTAGTTGTTAGAACTGGGGTTGGGGGAACTACTGTCATCTGGTGGGGAGAGACCGGCAATGCTGTTGATCTTACTATAATGCACAGGCCACCCCCAACAACAAACAAATTACATAGCCCCAAATATCAATAATGCCAAGGTCCAAATAACCTAACCTTCCATTACTGAAAATAGAAGTTCAAGAAGATAGTTTATAATTTAAAAATTTTTAGGTCTTAATAAGTTGTCATACTTTCACAGGTTTTATTTCATACTAAGTAATTTATTTCAAATTTTACATTCCAATTACAGAAAATTTTCTAAGCCAGTTTTTGTTCTTCATGAGTATTACTATCAAGGTCACATTTTTCATCTAGTATGTTTTACCCTGGTACTTGTTGGCAGGGTCAGGACTAAGGTGAGATGCGCAAGGCATTTGCCTCACACAAAATGCACAATGAATAAAATGTCAAAACTTTAAATAAAGACAGAATCACTAAAAGTACTTTGCCATATTGGAACCTGAGGCAAAAAGAAAAATAAGTAATAATATTTAAAATTTTGATCTCTTGTTCATTGTAGATTTTTACATTAATTTTGATTGTTTAAAACATTGCATTAAAATATTATTTAATGTGAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA</dnaseq>
 +
 +
==Labs working on this lncRNA==
 +
* General Surgery of Xiangya Hospital, Central South University, Changsha, China.<ref name="ref1" />
 +
 +
==References==
 +
<references>
 +
<ref name="ref1"> Huang H, Chen J, Ding CM, Jin X, Jia ZM, Peng J. LncRNA NR2F1-AS1 regulates
 +
hepatocellular carcinoma oxaliplatin resistance by targeting ABCC1 via miR-363. J
 +
Cell Mol Med. 2018 Jun;22(6):3238-3245. doi: 10.1111/jcmm.13605. Epub 2018 Mar
 +
30. PubMed PMID: 29602203; PubMed Central PMCID: PMC5980138.
 +
</ref>(1)
 +
</references>

Latest revision as of 10:26, 21 August 2019

Annotated Information

Name

Approved Symbol: NR2F1-AS1

Approved Name: NR2F1 antisense RNA 1

Synonyms: FLJ42709

RefSeq ID: NR_021490

Ensembl ID: ENSG00000237187

LncBook ID: HSALNT0091577

Chromosome

5q15

Expression

lncRNA NR2F1-AS1 is up-regulated in oxaliplatin-resistant hepatocellular carcinoma (HCC) tissue.[1]

Function

In vitro,NR2F1-AS1 knockdown reduced the invasion, migration, drug-resistant gene (MDR1, MRP5, LRP1) and IC50 value in Huh7/OXA and HepG2/OXA cells. In vivo, NR2F1‐AS1 knockdown decreased the tumour weight of HCC cells.[1] Bioinformatics tools and luciferase reporter assay confirmed that NR2F1-AS1 regulates hepatocellular carcinoma (HCC) oxaliplatin resistance through targeting miR-363-ABCC1 pathway. [1]

Sequence

>gi|565671824|ref|NR_021490.2| Homo sapiens NR2F1 antisense RNA 1 (NR2F1-AS1), transcript variant 3, long non-coding RNA

000001 GGCGCGGAGC CGCGCGGAGT GACAAAGCCG CCGCTGCCGC CGCCGGGGGT GGGAGCCGCG CTCGCCCGCC CGCCCCTCGA 000080
000081 CTCGCGAGGG CGTAAAAGTT TGTCTCAGCT CGAGCATTCC TAGCGCCAAC ACGCCCTCAG GTAAAGGTGG AAGTAAATGG 000160
000161 CCACGCTGTA TTGACAGAGC AGGTAGATGA AACTCAAGAG AAAAGGTGTG GATAAATGAA ACTAGCCCAT GATGAACCTG 000240
000241 TTTTCTCCGT GACCACAATA TTAACCAGGA TGAATGGCGG TGGCAGTGGG CCTGCATCAC AGGTTGCAGC AGATGTTCTC 000320
000321 AATATTTCTA TTAAAATTTC CTTATTTCCA TATGCAAGAG GAGCCCCAGA GCTGCATCCT TATGGTAGCT ACCATGCCGT 000400
000401 GATGTAAGCT GCCATTCACT GGGGAGCTTT GGCAATAGAA TTGGCTAGAT CAGGAAGCCT ATGTCAACTA TGGAACAACA 000480
000481 ACTTGCAGCT CATCTCTATT GATGATGGAA TCTCGCTATG TCACCAGGCT GGAGTGCAGT GGCGCAACCT CGGCTCAGCG 000560
000561 CAACATCCGC CTCCCGGGTT CAAGTGATTC TCCTACCTCA GCCTCCTGAG TAGCTGGGAT TACAGGAATC TAATGACCAT 000640
000641 TGAACTGTGG CCATGACTTC AATTACAAGT ATTTTCTTCA CTAATGTCAG ACTGTGGGCC TTTGTATATA CACTTTTAAC 000720
000721 AAACTTTTTG GAAGTGCAAT ACATATCGCA ACAACTTCTC AATGCTGAAT CATAGTATTG GAAGACATTT TAAGCAACAA 000800
000801 TTAAACTCAA CTTATTTACT ACCAATAATG TACATAAGTC AGCTGAAGTG AGGATAACAT GAATAGCACA AATACATTAT 000880
000881 GATTGCTGCC TGGCCAACAG TAATTATAAG AAACTGTCAG TTTTGAGATG TGTCTTGATT TCAGAGATGT TAAAAAAGTT 000960
000961 TGTAAGTTAC CATTGATAAA ATATGAGTTT GCTTCCACAA ATATTCTTTC TTCTGTCCTT CTGGAACTCA AGAGTAAACA 001040
001041 TATATTAGAT TTTCTCACCA TTTCATGCAT GCTGGTTCCT AGGCTACTCT CTGAGTCATT TTTTTTTTCT TATCTGCCCT 001120
001121 CCAGTTCACT AGTTCTGTCA TTTTCTGGGT CTGATCTGCT GCAAATGCAA TACATTGAGT TTTAAATTTC AGTCATTGTG 001200
001201 TTTTCATTTC TAGAAATTTC ATTTGACTCT TTCTCAAATT ACTTTTCCAT TTTTTTTGTA GTTTCCTATC CCTGGAGATA 001280
001281 TTTTCAATCA TGCCATTTAA TTTTTTAAAT ACGCAAGTGT AGTTTTATAA TTTGTGTCTG ATAATTCTAA TATCTGAAGT 001360
001361 CTTAGTAGGT CTGTTTCAGT TGTCCTGTAA TTATGCATGT TTTTGCCCAT GTTGCTTTGT TTCCTTGTAT GCTTGGTTAT 001440
001441 CTTTCTTACT GCCCTTGCAA AATTATTTGG AGAGTCCTGG AGGCTTAAAT GAAGATAACT TTTAGGAATA ATTTGCATTT 001520
001521 GCTTTTGCCG AGGATCTTGG GATCATTTCA ACCAAAATCT TAGCTTGAAA TTCCGCAATC AATCAAGGTG ATGAGAACCT 001600
001601 GGTCAGTAAA TCCTAATGAG GGCCAGGCTG TGGCCAAAGA TTTTTAGACA GATGTTTCCC TCCTTTGCCA TTTCTCTTTT 001680
001681 CTTTCCTCCT CTGCTCCTCT TAGTGTCCAG ACAACCTTCA TGGAAGTCCT TGGGGTGGGT GGGAAATGAG GACGGCAGGT 001760
001761 TTCATTCTAG GTATAGCCCT TTGAGGTCTA ACTTAATGCA GAGAGAGTTT TCTGGTCTAT GTGCCACCTT ACATGGGATC 001840
001841 TTGAGCCTTG ATTTCTAAAC CCCTTGCCTT TGATGTTTCA GAATTGAAGC TTAAATTTGC CAACAGGCAA ATGTCCTCAA 001920
001921 GGCAAATTGG CTTAGGTGTT CGATATTCTT CTTACCAGAA AGGTAAACTT GGGTTTTTTA CTTCACCCAG GATTTGGCAT 002000
002001 GACAGTTCCC CATTATCTTG TCAGCTTAGT GCTTTAAGTG ATTGCATTTA AAAAAATTCT GCATTTTCAG TTTTTAGCAG 002080
002081 GAGGAATGGC CTCAACTAGT GGTTTTCAAC TGGGGATGAT TTTTTTCCCC TAGGGGACAT TTGATAATGT TTGGAGATGT 002160
002161 TTTAGTTGTT AGAACTGGGG TTGGGGGAAC TACTGTCATC TGGTGGGGAG AGACCGGCAA TGCTGTTGAT CTTACTATAA 002240
002241 TGCACAGGCC ACCCCCAACA ACAAACAAAT TACATAGCCC CAAATATCAA TAATGCCAAG GTCCAAATAA CCTAACCTTC 002320
002321 CATTACTGAA AATAGAAGTT CAAGAAGATA GTTTATAATT TAAAAATTTT TAGGTCTTAA TAAGTTGTCA TACTTTCACA 002400
002401 GGTTTTATTT CATACTAAGT AATTTATTTC AAATTTTACA TTCCAATTAC AGAAAATTTT CTAAGCCAGT TTTTGTTCTT 002480
002481 CATGAGTATT ACTATCAAGG TCACATTTTT CATCTAGTAT GTTTTACCCT GGTACTTGTT GGCAGGGTCA GGACTAAGGT 002560
002561 GAGATGCGCA AGGCATTTGC CTCACACAAA ATGCACAATG AATAAAATGT CAAAACTTTA AATAAAGACA GAATCACTAA 002640
002641 AAGTACTTTG CCATATTGGA ACCTGAGGCA AAAAGAAAAA TAAGTAATAA TATTTAAAAT TTTGATCTCT TGTTCATTGT 002720
002721 AGATTTTTAC ATTAATTTTG ATTGTTTAAA ACATTGCATT AAAATATTAT TTAATGTGAA AAAAAAAAAA AAAAAAAAAA 002800
002801 AAAAAAAAAA AAAA

Labs working on this lncRNA

  • General Surgery of Xiangya Hospital, Central South University, Changsha, China.[1]

References

  1. 1.0 1.1 1.2 1.3 Huang H, Chen J, Ding CM, Jin X, Jia ZM, Peng J. LncRNA NR2F1-AS1 regulates hepatocellular carcinoma oxaliplatin resistance by targeting ABCC1 via miR-363. J Cell Mol Med. 2018 Jun;22(6):3238-3245. doi: 10.1111/jcmm.13605. Epub 2018 Mar 30. PubMed PMID: 29602203; PubMed Central PMCID: PMC5980138.