Difference between revisions of "PXN-AS1"
(Created page with "PXN-AS1 plays an important role in a variety of cancers<ref name="ref1" /> ==Annotated Information== ===Name=== A...") |
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| − | PXN-AS1 | + | LncRNA PXN-AS1 is upregulated in NPC and promoted NPC malignancy by upregulating SAPCD2 via direct RNA-RNA interaction.<ref name="ref1" /> |
==Annotated Information== | ==Annotated Information== | ||
===Name=== | ===Name=== | ||
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Approved name:PXN antisense RNA 1 | Approved name:PXN antisense RNA 1 | ||
| − | HGNC ID | + | HGNC ID:44123 |
Previous name:PXN antisense RNA 1 (non-protein coding) | Previous name:PXN antisense RNA 1 (non-protein coding) | ||
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PXN-AS1-L is upregulated in NPC tissues and cell lines.<ref name="ref1" /> | PXN-AS1-L is upregulated in NPC tissues and cell lines.<ref name="ref1" /> | ||
===Function=== | ===Function=== | ||
| − | PXN-AS1-L | + | PXN-AS1-L interacts with SAPCD2 mRNA 3'-untranslated region, prevents the binding of microRNAs-AGO silencing complex to SAPCD2 mRNA, and upregulates the mRNA and protein level of SAPCD2.<ref name="ref1" /> |
| − | === | + | ===Expression=== |
| + | [[File: PXN-AS1.png|thumb|300px|Overexpression of PXN‐AS1‐L promotes nasopharyngeal carcinoma cell proliferation, migration, and invasion.<ref name="ref1"/>]] | ||
PXN-AS1-L overexpression promotes NPC cell proliferation, migration, and invasion in vitro, and NPC tumor growth in vivo. PXN-AS1-L silencing suppresses NPC cell proliferation, migration, and invasion in vitro.<ref name="ref1" /> | PXN-AS1-L overexpression promotes NPC cell proliferation, migration, and invasion in vitro, and NPC tumor growth in vivo. PXN-AS1-L silencing suppresses NPC cell proliferation, migration, and invasion in vitro.<ref name="ref1" /> | ||
| − | === | + | ===Regulation=== |
LncRNA PXN-AS1-L is upregulated in NPC and promoted NPC malignancy by upregulating SAPCD2 via direct RNA-RNA interaction.<ref name="ref1" /> | LncRNA PXN-AS1-L is upregulated in NPC and promoted NPC malignancy by upregulating SAPCD2 via direct RNA-RNA interaction.<ref name="ref1" /> | ||
===Diseases=== | ===Diseases=== | ||
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*Department of Otolaryngology, Henan Province People's Hospital of Henan University, Zhengzhou, China.<ref name="ref1" /> | *Department of Otolaryngology, Henan Province People's Hospital of Henan University, Zhengzhou, China.<ref name="ref1" /> | ||
*Department of Radiotherapy, Henan Province People's Hospital of Henan University, Zhengzhou, China.<ref name="ref1" /> | *Department of Radiotherapy, Henan Province People's Hospital of Henan University, Zhengzhou, China.<ref name="ref1" /> | ||
| − | ==References== | + | ==References== |
| + | <references> | ||
<ref name="ref1">Jia X, Niu P, Xie C, Liu H. Long noncoding RNA PXN-AS1-L promotes the malignancy of nasopharyngeal carcinoma cells via upregulation of SAPCD2. Cancer Med. 2019 Aug;8(9):4278-4291. doi: 10.1002/cam4.2227. Epub 2019 Jun 7. </ref>(1) | <ref name="ref1">Jia X, Niu P, Xie C, Liu H. Long noncoding RNA PXN-AS1-L promotes the malignancy of nasopharyngeal carcinoma cells via upregulation of SAPCD2. Cancer Med. 2019 Aug;8(9):4278-4291. doi: 10.1002/cam4.2227. Epub 2019 Jun 7. </ref>(1) | ||
</references> | </references> | ||
Revision as of 04:13, 19 February 2021
LncRNA PXN-AS1 is upregulated in NPC and promoted NPC malignancy by upregulating SAPCD2 via direct RNA-RNA interaction.[1]
Contents
Annotated Information
Name
Approved symbol:PXN-AS1
Approved name:PXN antisense RNA 1
HGNC ID:44123
Previous name:PXN antisense RNA 1 (non-protein coding)
Alias symbol:EyeLinc4
RefSeq ID:NR_038924
LncBook ID:HSALNG0094500
Characteristics
PXN-AS1-L is upregulated in NPC tissues and cell lines.[1]
Function
PXN-AS1-L interacts with SAPCD2 mRNA 3'-untranslated region, prevents the binding of microRNAs-AGO silencing complex to SAPCD2 mRNA, and upregulates the mRNA and protein level of SAPCD2.[1]
Expression
File:PXN-AS1.png
Overexpression of PXN‐AS1‐L promotes nasopharyngeal carcinoma cell proliferation, migration, and invasion.[1]
PXN-AS1-L overexpression promotes NPC cell proliferation, migration, and invasion in vitro, and NPC tumor growth in vivo. PXN-AS1-L silencing suppresses NPC cell proliferation, migration, and invasion in vitro.[1]
Regulation
LncRNA PXN-AS1-L is upregulated in NPC and promoted NPC malignancy by upregulating SAPCD2 via direct RNA-RNA interaction.[1]
Diseases
Nasopharyngeal carcinoma (NPC) malignancy[1]
Labs working on this lncRNA
- Department of Otolaryngology, Henan Province People's Hospital of Henan University, Zhengzhou, China.[1]
- Department of Radiotherapy, Henan Province People's Hospital of Henan University, Zhengzhou, China.[1]
