NONHSAT104559

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Annotated Information

Name

Alpha 250/ Alpha 280

Characteristics

Two overlapping antisense RNAs from intron 1 of the human ribosomal protein 14 (Rps14) gene, identified by RNase Protection Assay (RPA).. RPA expression analysis using both cell extracts and cell-free transcription system indicates full-length sizes of 250 and 280 nt, respectively. Transcripts terminate at the same nucleotide, therefore alpha-250 overlaps alpha-280 along its whole length.. Transcription of both RNAs is resistant to high concentrations of RNAPII inhibitor alpha-amanitin.

Function

Regulates RPS14 transcription.. Each lncRNA can interact with the Rps14 gene loci to stimulate its expression in-trans.. Each lncRNA is transcribed through a known enhancer with putative transcription factor binding abilities, suggesting the 'enhancer' may be the transcribed RNA, which could be recruiting transcription factors to the Rps14 gene.

Expression

Ubiquitously expressed in the human tissues and cell lines examined. . Alpha-250 was almost exclusively cytoplasmic. Alpha- 280 was mostly in the nucleus.

Conservation

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Misc

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Transcriptomic Nomeclature

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Regulation

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Allelic Information and Variation

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Evolution

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Labs working on this lncRNA

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References

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Basic Information

Transcript ID	NONHSAT104559
Source	NONCODE4.0
Same with	,
Classification	antisense
Length	290 nt
Genomic location	chr5+:149828969..149829258
Exon number	1
Exons	149828969..149829258
Genome context
Sequence	000001 TACGCTGTGC AGCTCAAACG CGGCCGTGGC CGTGGCCGTA TTGCGGGGCC GAGGCCTTAA AAGGCTGGAC CCGCACTCAC 000080 000081 CCTTACTTCA CAAGCTCCTC CCTGAAAGCA AAACGGGCCT TCTGAGACCA GGAACGAACT CAATCCCGAG TTGGCCAGGA 000160 000161 TCCAGGTGGG CCAGCCGCGC GTCTCTTGCC CGGCACCTAG CTCGGTTCCC ACGGAAAGAC CCCCGTCTCT CGTCCCAAGC 000240 000241 CCCACAGGGT CCCCTCGCCG CAGGATGCCC CCCGATTGTC GCGCCCGGGC

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