Difference between revisions of "NONHSAT106529"
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===Function=== | ===Function=== | ||
| − | [[File:FOXC1 and lncRNA-FOXCUT expression levels were elevated in metastatic ESCC and poorly differentiated tumor tissues.jpg|right|thumb|400px'''FOXC1 and lncRNA-FOXCUT expression levels were elevated in metastatic ESCC and poorly differentiated tumor tissues.'''<ref name="ref1" />]] | + | [[File:FOXC1 and lncRNA-FOXCUT expression levels were elevated in metastatic ESCC and poorly differentiated tumor tissues.jpg|right|thumb|400px|'''FOXC1 and lncRNA-FOXCUT expression levels were elevated in metastatic ESCC and poorly differentiated tumor tissues.'''<ref name="ref1" />]] |
''FOXCUT'' that co-interacted with FOXC1, may be functionally involved in the tumor progression and survival of ESCC patients, such as the upregulation of FOXC1 and FOXCUT were correlated with poor prognosis in ESCC patients, which may represent a potential prognostic biomarker and therapeutic target for ESCC patients <ref name="ref1" />. | ''FOXCUT'' that co-interacted with FOXC1, may be functionally involved in the tumor progression and survival of ESCC patients, such as the upregulation of FOXC1 and FOXCUT were correlated with poor prognosis in ESCC patients, which may represent a potential prognostic biomarker and therapeutic target for ESCC patients <ref name="ref1" />. | ||
| Line 16: | Line 16: | ||
===Expression=== | ===Expression=== | ||
| − | [[File:The expression of FOXC1 and FOXCUT.jpg|right|thumb|400px'''The expression of FOXC1 and ''FOXCUT''.'''<ref name="ref1" />]] | + | [[File:The expression of FOXC1 and FOXCUT.jpg|right|thumb|400px|'''The expression of FOXC1 and ''FOXCUT''.'''<ref name="ref1" />]] |
FOXC1 and ''FOXCUT'' were co-overexpressed in ESCC tissue specimens and ESCC cell lines. The expression of ''FOXCUT'' and FOXC1 (lncRNA-mRNA gene pair) were both identified to be upregulated in 82 ESCC tissues compared with adjacent noncancerous tissues, and the expression of FOXC1 was also decreased as the ''FOXCUT'' expression was downregulated by siRNA. | FOXC1 and ''FOXCUT'' were co-overexpressed in ESCC tissue specimens and ESCC cell lines. The expression of ''FOXCUT'' and FOXC1 (lncRNA-mRNA gene pair) were both identified to be upregulated in 82 ESCC tissues compared with adjacent noncancerous tissues, and the expression of FOXC1 was also decreased as the ''FOXCUT'' expression was downregulated by siRNA. | ||
Revision as of 08:43, 5 April 2015
FOXCUT,a novel long non-coding RNA FOXCUT ( FOXC1 promoter upstream transcript), which co-operated with its neighboring gene FOXC1 as lncRNA-mRNA pair, played a significant role in the oncogenesis and progression of esophageal squamous cell carcinoma (ESCC).
Contents
Annotated Information
Transcriptomic Nomeclature
FOXCUT,FOXC1 upstream transcript(HGNC nomenclature)
"FOXC1 promoter upstream transcript", TCONS_00011636 [1]
Function
FOXC1 and lncRNA-FOXCUT expression levels were elevated in metastatic ESCC and poorly differentiated tumor tissues.[1]
FOXCUT that co-interacted with FOXC1, may be functionally involved in the tumor progression and survival of ESCC patients, such as the upregulation of FOXC1 and FOXCUT were correlated with poor prognosis in ESCC patients, which may represent a potential prognostic biomarker and therapeutic target for ESCC patients [1].
Diseases
esophageal squamous cell carcinoma(ESCC) [1]
Expression
The expression of FOXC1 and FOXCUT.[1]
FOXC1 and FOXCUT were co-overexpressed in ESCC tissue specimens and ESCC cell lines. The expression of FOXCUT and FOXC1 (lncRNA-mRNA gene pair) were both identified to be upregulated in 82 ESCC tissues compared with adjacent noncancerous tissues, and the expression of FOXC1 was also decreased as the FOXCUT expression was downregulated by siRNA.
| siRNA primer | Forward | Reverse |
|---|---|---|
| FOXC1 | 5'- GGCGAGCAGAGCTACTACC -3' | 5'- TGCGAGTACACGCTCATGG -3'[1] |
| FOXCUT | 5'- GTCGCACCGATGACTAACG -3' | 5'- GCCCTGAAAGCCGAACTG -3'[1] |
Labs working on this lncRNA
- Key Laboratory of Oncology, Cancer Center, Division of Internal Medicine, Chinese PLA General Hospital & Chinese PLA Medical School, Beijing, China [1]
References
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 Pan F, Yao J, Chen Y, Zhou C, Geng P, Mao H, et al. A novel long non-coding RNA FOXCUT and mRNA FOXC1 pair promote progression and predict poor prognosis in esophageal squamous cell carcinoma[J]. International journal of clinical and experimental pathology. 2014,7(6):2838-49.
Basic Information
| Transcript ID |
NONHSAT106529 |
| Source |
NONCODE4.0 |
| Same with |
FOXCUT, TCONS_00011636 |
| Classification |
antisense,sense |
| Length |
6813 nt |
| Genomic location |
chr6-:1603265..1642995 |
| Exon number |
5 |
| Exons |
1603265..1608466,1610339..1610832,1612000..1612105,1630113..1630326,1642199..1642995 |
| Genome context |
|
| Sequence |
000001 CCAGCACAGC TGCCCACCTG TGCTATTCAC AAAGACACAA GAAGCCATCA TGAAGCAGGC TTTATAAAGT CAAAATATTA 000080 000081 CTCCACGTCT GTTATGCATA AGGACTCAGG ACGATGGTCA CCATGGAACC CCGTTCTCCA ACCTAGAGGA CAAAGACCAG 000160 000161 GTTGACCTTC ACCTTAGGGG GAAGGTGGAG ATTTTGAAGG AGAAATTTAT TTTCTCCCTG ACAAAACCAA AATTTTCAGA 000240 000241 CAAATCTGAG CAACAGTTAT AGAACCTTTG GGGTAGGTTT AAAGACGGAA ACTGGCCGGG TGTGGTGGCT CACGCCTGTA 000320 000321 ATCCCAGCAT TTTGGGAGGC CGAGGTGGGC CGATCATTTG AGGTCAGGAG TTTGAGACTA GCCTGACCAA CATGGTGAAA 000400 000401 CCCTGTCTCT ACTAAAGACA CAAAAATATT AGCCGGGCGT GGTGGCACAT TCCTGTAGTC CCAGCTGCTT GGGAACCTGA 000480 000481 GGCAGGAGAA TCTCTTGAAC CTGGGAGGTG GAGGTTGCAG TGAGCCGAGA TCACACCACT GCACTCCAGC CTGGGCGATA 000560 000561 GAGTGAGACT CTATTTTTTT CTTAAAAAAA AAAAAAAAAA AAAAAAAAGA TGGAAACTGC CCAGATTTCA AGAGAATTGA 000640 000641 GGCTTGCTGC GCTCCCCTTA GTTTCTGAAG AGCAGGGTTC CAAGTGAGCG AGGACAGGAT GAAAAGGAGA GTGCTACGCA 000720 000721 GGGCGATCTT TCTGAGCCAG GGGCCAGTAG GAAAGGACAG GGGCATCCTG AAGGAGCAGG TGAAACGAGG GCCTTCTCAT 000800 000801 ATTTTTAAAA TATAAATGAA AAAAGATCCA TTTATATGTA GGTTGCACTA TACATGCCAT TAAGTTCTCC TTTCCTGAAG 000880 000881 TGAACACCTG TAACTTTTTT TACCACCCTA AGCTTTATTG ACAAGTAGGC ATATAATGAA GACCACGTTC TCATTTACTT 000960 000961 TCCACGAAAG CTCTACTGTA CTAGCCGGAC TTTGTCGCTG GTTTCTGGGG CCAGGTACCA CGAGGTGAGG CGGCCTTGGT 001040 001041 GGGCCGCAGG GTGGTGGCCG GCCTCCTGGC CTCCCCCGCC GCCGCCGCCG CCGCCGCCGT GACTCAGGGA CGACGAGGCA 001120 001121 GGGTGCGAGT ACACGCTCAT GGGGGCCGGC ATGGCGGTGT AGCCGCCCCC GGCCGCCGCG GCCGCCGCGC GGTAGTAGCT 001200 001201 CTGCTCGCCG CCGAGGTAGG GCACCACTCC CAGGGAGTTG GGGCTGGACA CGGAGTAGCG CGCCTGCATG GCCCCCGCTC 001280 001281 GCCGCCGCCC CGCGCCGCCC GCCGCCCCCC ACCCTCGCTC GGGCCGGGCC GCGCCGCGCC GGCCGCCGAG TCCGAGTCCG 001360 001361 GGCCCGGCCG AGCTGGTGCC GGCCCGCTGC GCTGTGCGTC CGGCTGCGCT GCCGCCTCTC CCGGCGCTCG CTGGGGCTGG 001440 001441 CTCCTCCGGC GCCTCGGGCT ACCTCGGGGC CCGCGCGGCC GCGAGGCGGG GTCGCTGCGA GGGGAGAAGG CCGGGCCCGG 001520 001521 CCGCGGCAGA CCGCCTTGCA GGAACTCGCG GCGCAGCTTC CAGGCGCAAA CGGGGGAAAG CAGACAAAAA GAAAGAACAA 001600 001601 GCAGGCGCCC TCTTTGGAGG AGGGAGGGTT GCCCCGAGGT TGCTCTGAAT CCCGGGGCAG CTGCCTCCTG GCCTGCTGTG 001680 001681 CGCCGGGGTC TCTGGAGACT CCTTTTCCAG GTGGTTTGCG GGCCAAGTCA CTGGTGGGTT GGAGAAGCAC CAACAGGAGG 001760 001761 CTCAGCACTT GCTGGTTGCC AAGGACACTA GACAGGGGCG AGGGTGGTGG TGAAGCCCCA GGACCTGAAC ACTTAATTCC 001840 001841 TGTTCAGCCC CCAGCCCGGC ACCCTGAAGG TCTTATCAGC CCGCCTGGTC GAGGCTTTAA GGAGTGCTGT GGCTTCAGCC 001920 001921 TGGAGGAGAT TTAAGTGGTC TCCCTGAACA CCTCAGCAAG TGGTGAGTTC GGTCTTGAAG CTGCCTTTTA CACTGCTAGC 002000 002001 GGTGCGCGGA GATGAACGCA GCGATTACGG ATGCTTTGTT TTCCGAATGC GGGAAACGCC TTCGGCCCCG AGTTTTGCAA 002080 002081 CAGGCAATGG TGCCCCGCTG CCCCCTCCCC CACCAGCCTG TCGCCTCCTG CTCTTCCCTG CCTCCTCCCT CCATCGGCCC 002160 002161 AGTGAAGTGT AAACAGCTTG TTATGTAAAT TGCAAATCGA CCTGCAGCGG TGTTCTCAGC TCTCCGTTTT GGGTATAAAA 002240 002241 GTCGCCGTTG TGAAATTAGT GTCTGGCGTG CGAGAAAAAA TGGAGGGACG TAGTTTTATC AAGATCAACT TTCCACTGGT 002320 002321 TTAGCTCTGG ATATTCGCCA GGAAAAGATA TTTGCATTTG TGTTTTATAA ACTTACTCGG AAGCAAGCCT CCAGTAAGCG 002400 002401 GCTTGATTGT ATTTCAAGCA CTTTTCTTAT TTCATTTTTG TTGTTAGTGG TGTTATTTGA ACATTAAGAC GCAGGCATGA 002480 002481 AGTCTTTTGG GGAACAGGTT AAAGCTTTTA TTTTCAGGTT ACAGTTTTTG ATGCCCCTTT CTGCTACTCC ACGGGGTACT 002560 002561 TCAATCATCC GCTTCCGCAC ATCTCTTGAC TCATTTGGCA GAAGAGCCCC CACGGGAACC CTTCGGCTTC TTTTCTGACA 002640 002641 CCTCACGTAC TTGCAGCCTG AAGGCCCCGC AGGCGACAGC GGTAATGGAT GTTTGGTGGA ACCCTCCCTG GGCCCACACT 002720 002721 CCGCCCCTCC CCAGCAGGCC GGGCAACAAT TCCCAGGGCC CACCGAGGGG TGCTTAGCTC GGAGGAGGGG GAGTGACGTC 002800 002801 ACAGCGATGT TCAAAACAAG GCCTCCCCTG GCCCCACCAT AGAAAAGCAC CAGGAAGGGG AATGTGGCGA GCACTCCAGG 002880 002881 AAATGCTCGG ATTGGGGACC AGGTGACACT GTAGGAATGT GTGTGCTGGG GGATGGGATG GTGTCCTAAA TATGGGTCAC 002960 002961 CAGGAGCCAG AAGGAGCTCT CTTTTTTCTT TTTCTTTTTC AAGTAAAGCA GAGGAGGTGG AGATTGGGAT GGGGGCAGTC 003040 003041 CGGAAAAATC ACTCCCTAGG GGTGTGAGCT TAGCTCGTGT TGTGCGGATT GTCCCCGTCA CAGCCCAATC ACCTCTGTGG 003120 003121 TGTGCCTAGA CGCCCTCTCC CTTACCTCCC CGCTTTCTGG CTTCTCCATC CTCTGGGCTC TGGGTTCAGC CCTGAAAGCC 003200 003201 GAACTGTGGG CTGCAGTGGG GAGGCGAGGG CAGGTAGAAA CCAGCTTCAG GGGGGGCTCC ACCTGGCCCA GGAGCTGGGG 003280 003281 GACAACAGAA AAGGCAGGCT TAGGGCATGA GGGAAGGCGC TTCTCCTGCT GCACTGGGGC AGTGATTCCT GGGGGCTCTG 003360 003361 CACACACAGG AGGGAGGCTG CAAGTCCACA GCTGCTTTAG CATCTTTCCC TTTGCTGGGG CAGACAGAGT GGAAGATTAA 003440 003441 GGCAATTAAC CCCAGAGGGC CACTAGAAAA CTGTCCACTA GGCTGCCATC ACAGACCACT GGAGCAAGGT CCGCTTGGGG 003520 003521 ATGTCTTTGA GCTTTTTAGA TTACTTAGAT AATTGTCTTA GTTCTCCATT CGGCCTCCTT TGCTTAGACC AGAATCCCAG 003600 003601 GGGTAGGGGA GGATATCCTT GCATCAATGC CCGGCATTCG TTTTCAAACC ACCAGGCCGG CAGGCAACGT TAGTCATCGG 003680 003681 TGCGACTTTT CAGCGGAGGA AGGAGTGGGG ACCGAACATC TGGGTGGCCG CGACCTTGGG CAGATACTCC TTAGCTGGGG 003760 003761 GATTTTCAAG TAGAGGATTT GTCAGCACAG TCCCTCCAAT TCAGCCCCGT CCTTAGTAGA AAAATTTCTA CAATAAACGA 003840 003841 AAAGAGCGTT TGGTTTTCGA TTGTTTTAAA GACAAAGTGA TCCATATTGC CTGTCTACAT GGTTGGATTA ATCCGATAGT 003920 003921 TGCCCTCCTG GGGGCAGACC TCCACGGGAA GTTTGTGTGA TGGGATAATT TAATGTCATC TAAGTCCCCT GGAGGGGCGG 004000 004001 TTCCCCTAAC TACTCACCCA GGAGAAAGCC AGCCAACACC TACCTGATCG TTCCCGCCTC GGGATGGCCC ACCTATCGCC 004080 004081 CCTTGGCAGG AAAGCCCCCG CCTCGAAGGG CGTTTCGGGG GCTCAGAGCC GAGCTAAGCT GCAAGAGGGG GCCATGGGGA 004160 004161 ATGCGGGAAG TGAATCTTTA ACTTTGGTGC CCGGCTTCAA AAGACTCAGG GCTTCTTGTG TTCAGGCAGA GGTAAATGGA 004240 004241 GATTCAAACT GTCGTCTTGC ATTAACAATC CGGAATAAAA ATAAAATTCG TAAAGGGATA GATGATCGGA AAGAACAAAT 004320 004321 GGTGCATGTG TGCGCGAACG AGCCCCAGTT TCTCTCCATC CAGGTCCCCA GCGGACTCAG AGCGGCCGCC GCACTCCACG 004400 004401 GCCTGGGAGG ACAGAGGCCC CGCAGCCTCC CAACCTCGGC TCATGTGGGG GGCGCGCCGC GCAGGGTGGG CGAGTCCCCA 004480 004481 GGCCCCAGAG TCTGCCGGAG CCAGGGTGCG CGGTGCGGCG GGAGCCGGCC GTCGGAGGAC TGCAGGGCGA AAGCGCCTTC 004560 004561 CTGGGGCTGG AGCAGAAGGC GTGTGCCCCT GCACGGACGC GCCTTGGCTG TGGGTGTGGG AAGAAAGGCT TTGCCCCGTG 004640 004641 AGACAGACCC ACAGACAGCC CCGGAGCCGC CGGCGGGGTG AGGTGGGCTG CAACCTTGCA GGTGGCTGGC TGTTCCCAGG 004720 004721 TCTCCGGCCC GGCGCCGCAG CGGACCCAGG CGCCGGGGCC GCAGCCAGCC TTCCTTCCGA GTGCTCCCTT CGCGGAACCC 004800 004801 TGCGCCCTGG GACCTTCCTT CCGACGTCCC TCACCCCGGC CGGGGAGTGG CACCAACGCG GACGCACCGC CGGGCCTCCT 004880 004881 GCGGGTAAGG CGCGGTCGGC CCCCAGCTCT GAGCCTTCTG GGCAGGAGCC CCGGGGGCCT GGGCCGGGGC CGGTGTTTGC 004960 004961 ACCTCTCAGG ACAGGGACAA GGCCGACACC CGGCTCGGTG CAGCCGGCCT CCCCCGAGGA CCTGAGGGCC GACGCCTCCG 005040 005041 GGAACCGCTG GTCCTCGCGA GTGGGTCGGC GCCTGGCAGC GCGCGCCGGT GACCTGGTGG TCCGTCTGCT CCCAGGCCGC 005120 005121 CCCTCACAGG CTTCCCGCCG CTTCCCCGCG AGCGTCAGCA GAAAAAGGGA CGATGTGGAA GCCCGGAGGC CCCTTGGCCG 005200 005201 ACCCAGGCTG GGGCTCTCAG GCTGGGGGCA CCTCACCCCG GCAGGTCCCG CGCCTCGGGA ACCCGGGGCC AGGCAGCCGT 005280 005281 CCTGGGCGCC CGCACCGCGC ACTGCGCGTG CTACGAGCGC CCCCTGCCGT CGGAGGCGTT GTCTCCGCGG CGCCTCTGCC 005360 005361 CGCGCCGGGC TCCAAGGGCC GGCTCCGCCT GTCCCCGCAC AGCGTCCCCT GGGAACCGGG TCTCCAGAGA AGGAGGCCTG 005440 005441 GGGAAGACCG CGCCGCCCGC GTGGGACCCC GCAGGGCCTG GCACCTGGTT TTCTAGGCTG CAACTCTCAT CCCTCAGGGT 005520 005521 CCGGGCGGGA ACAGCCCCAT CGGGGAGACC CTCTCAGACT TCCAGGCACA GACCACGGAC GCTTTTGTTC CTGGAGTGGA 005600 005601 GGGAGGTGAC CCGAGACTGG GGCTTTCAGC CACCGCTACG CATTCCTTCC AGGCGGCCCT TTTAATTGAC GTACACGTTA 005680 005681 CAGAAAAAGC AAGGCCGCTC CATCCAGTGA ATTAC |