Difference between revisions of "ENST00000579368.1"
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| − | + | GACAT2,gastric cancer associated transcript 2 (non-protein coding),was significantly decreased in gastric cancer tissues and cell lines which may be a biomarker for prognosis. | |
==Annotated Information== | ==Annotated Information== | ||
===Transcriptomic Nomeclature=== | ===Transcriptomic Nomeclature=== | ||
| − | + | GACAT2,gastric cancer associated transcript 2 (HGNC nomenclature) | |
| + | |||
| + | HMlincRNA717<ref name="ref1" /> | ||
===Function=== | ===Function=== | ||
| − | + | GACAT2 was significantly decreased in dysplasia. In addition, It is also a dysregulative molecule underlying gastric precancerous lesions that suggested that it may play crucial roles during cancer occurrence and progression<ref name="ref1" />. | |
| − | === | + | ===Diseases=== |
| − | + | Gastric cancar<ref name="ref1" />. | |
===Expression=== | ===Expression=== | ||
| − | + | [[File:GACAT2 expression levels in gastric cancer tissues and adjacent normal tissues.gif|right|thumb|400px|'''GACAT2 expression levels in gastric cancer tissues and adjacent normal tissues'''<ref name="ref1" />]] | |
| + | |||
| + | HMlincRNA717 expression was significantly decreased in gastric cancer tissues and cell lines. The downregulation expression of HMlincRNA717 was associated with cancer distal metastasis, venous invasion, and PNI<ref name="ref1" />. | ||
| − | + | The sequences of the PCR primers for glyceraldehyde 3-phosphate dehydrogenase (GAPDH) and HMlincRNA717 were as follows: | |
| − | |||
| − | === | + | {| class='wikitable' stytle="text-align:center" |
| − | + | |- | |
| + | ! | Primer | ||
| + | ! | Sense Primer | ||
| + | ! | Antisense Primer | ||
| + | |- | ||
| + | | rowspan="1"| GAPDH | ||
| + | | |5'-ACCCACTCCTCCACCTTTGAC-3' | ||
| + | | |5'-TGTTGCTGTAGCCAAATTCGTT-3'<ref name="ref1" /> | ||
| + | |- | ||
| + | | rowspan="1"| GACAT1 | ||
| + | | | 5'-TGGATGCTTACAAAGGACTGG-3' | ||
| + | | | 5'-CTGCAATTACGGAAAGAGCTG-3'<ref name="ref1" /> | ||
| + | |} | ||
| − | |||
==Labs working on this lncRNA== | ==Labs working on this lncRNA== | ||
| − | + | Department of Biochemistry and Molecular Biology and Zhejiang Provincial KeyLaboratory of Pathophysiology, Ningbo University School of Medicine, Ningbo, 315211, China<ref name="ref1" />. | |
==References== | ==References== | ||
| − | + | <references> | |
| + | <ref name="ref1">Shao Y, Chen H, Jiang X, Chen S, Li P, Ye M, et al. Low expression of lncRNA-HMlincRNA717 in human gastric cancer and its clinical significances[J]. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. 2014,35(10):9591-5.</ref>(1) | ||
| + | </references> | ||
{{basic| | {{basic| | ||
Revision as of 09:48, 5 April 2015
GACAT2,gastric cancer associated transcript 2 (non-protein coding),was significantly decreased in gastric cancer tissues and cell lines which may be a biomarker for prognosis.
Contents
Annotated Information
Transcriptomic Nomeclature
GACAT2,gastric cancer associated transcript 2 (HGNC nomenclature)
HMlincRNA717[1]
Function
GACAT2 was significantly decreased in dysplasia. In addition, It is also a dysregulative molecule underlying gastric precancerous lesions that suggested that it may play crucial roles during cancer occurrence and progression[1].
Diseases
Gastric cancar[1].
Expression
GACAT2 expression levels in gastric cancer tissues and adjacent normal tissues[1]
HMlincRNA717 expression was significantly decreased in gastric cancer tissues and cell lines. The downregulation expression of HMlincRNA717 was associated with cancer distal metastasis, venous invasion, and PNI[1].
The sequences of the PCR primers for glyceraldehyde 3-phosphate dehydrogenase (GAPDH) and HMlincRNA717 were as follows:
| Primer | Sense Primer | Antisense Primer |
|---|---|---|
| GAPDH | 5'-ACCCACTCCTCCACCTTTGAC-3' | 5'-TGTTGCTGTAGCCAAATTCGTT-3'[1] |
| GACAT1 | 5'-TGGATGCTTACAAAGGACTGG-3' | 5'-CTGCAATTACGGAAAGAGCTG-3'[1] |
Labs working on this lncRNA
Department of Biochemistry and Molecular Biology and Zhejiang Provincial KeyLaboratory of Pathophysiology, Ningbo University School of Medicine, Ningbo, 315211, China[1].
References
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 Shao Y, Chen H, Jiang X, Chen S, Li P, Ye M, et al. Low expression of lncRNA-HMlincRNA717 in human gastric cancer and its clinical significances[J]. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. 2014,35(10):9591-5.
Basic Information
| Transcript ID |
ENST00000579368.1 |
| Source |
Gencode19 |
| Same with |
lnc-PPP4R1-7:1,NONHSAT057182 |
| Classification |
intergenic |
| Length |
818 nt |
| Genomic location |
chr18-:8695854..8707619 |
| Exon number |
2 |
| Exons |
8695854..8696119,8707068..8707619 |
| Genome context |
|
| Sequence |
000001 ACAATAAATA AAACAGTTGG TGTCAATACA ACTCCCCTTA TTTTCTCTCA AGTCACCTGG ATCGTCCTGA CCCCGGGAAC 000080
000081 CCCGTCTGCA GCACCAGGCC CCCTCCGTGG AGAAAAGATG GAGCCGGATT AAGCACCCAG TGCTAAGGCG ACTAAGACGC 000160 000161 CACTGCCCGC AGGCCCTGCC GGAAAATACT CAGAGAGTGC AGCAGGCGCC GCGATTCCTT AGAAAGTGCT GGCGTGGCCT 000240 000241 CTCCTGACAC AGAAAGCCGG CTCCTGGATG CTTACAAAGG ACTGGCCCGC GCAACACCGT TGCTCCTCAA CCCGGGCCAC 000320 000321 ACTCCAAGGA CCTCTACTGA GCTTCAGCTT GCTCACCGAA AACGGCGCGG CCCCCTCTAC CCGGGATGTC GGAGCCCAGG 000400 000401 AGACCCTGAG AGCCCCCAGC TCTTTCCGTA ATTGCAGGAG AAGGGGCAAG CGGGTCCGTA GCCGGGGGCC CTCCAGTGGC 000480 000481 ATTATCCTGA ACCGCCACGC CCGCACGTGG CCCGGCTAGA GCTCCCTGGC GAAGGATCAC CTGTTCCTAC AGTGACAACT 000560 000561 GGACCTGGCC CGAACCCCTG GCATCTGGCA ACATTATTAC CTGTCGAAAC AGAAGTAGAG ATTTGAAATA GAGGATGCCT 000640 000641 GTTCCCATTT CCTCCTGCTG TCTGGAAGGA AGTCTGGCTT TCCAGCCCAA CTCTAAGCTC ATCTTTACAT ACAAAATAAG 000720 000721 GGTATGTTTA CATGGAAAGC AAAAATAGAA CCATGGATTT ACAGAAGGTT CCATAGCAGC AAATAACAGT GCTTATGAAA 000800 000801 TAAACATTTT AAATATTA |
