Difference between revisions of "ENST00000531381.1"
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==Annotated Information== | ==Annotated Information== | ||
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''MIR100HG'':mir-100-let-7a-2 cluster host gene(HGNC nomenclature) | ''MIR100HG'':mir-100-let-7a-2 cluster host gene(HGNC nomenclature) | ||
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===Diseases=== | ===Diseases=== | ||
* myeloid leukemia | * myeloid leukemia | ||
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==Labs working on this lncRNA== | ==Labs working on this lncRNA== | ||
Revision as of 06:31, 25 June 2016
MIR100HG, the human miR-99a/100 ~ 125b cluster host gene, locating in the nuclear cell compartment, plays a role in the regulation of erythro-megakaryocytic development.
Contents
Annotated Information
Name
MIR100HG:mir-100-let-7a-2 cluster host gene(HGNC nomenclature)
"adipogenesis down-regulated transcript 1", AGD1, "lncRNA neuronal 2", lncRNA-N2[1]
Characteristics
MIR100HG was localized in the nucleus and their expression correlated with the corresponding miRNA clusters[1].
It was contained in BH3-like motif ,which was associated with the single nucleotide polymorphism (SNP) rs577948, a susceptibility locus for high myopia in Japanese subjects[2].
Cellular Localization
MIR100HG was localized in the nucleus[1].
Function
Knockdown of MIR100HG impaired cell viability and replating-efficiency of AMKL（acute megakaryoblastic leukemia） cells,which implys MIR100HG may contributes to the maintenance of leukemic growth[1].
Diseases
- myeloid leukemia
Labs working on this lncRNA
- Pediatric Hematology and Oncology, Hannover Medical School, Carl-Neuberg-Straße 1, 30625 Hannover, Germany[1]
- School of Optometry and Ophthalmology and Eye Hospital, Wenzhou Medical College, Wenzhou, Zhejiang, China[2]
References
Basic Information
| Transcript ID |
ENST00000531381.1 |
| Source |
Gencode19 |
| Same with |
lnc-BLID-1:4,NONHSAT024776,MIR100HG,AGD1, lncRNA-N2 |
| Classification |
intergenic |
| Length |
3370 nt |
| Genomic location |
chr11-:121959811..121972886 |
| Exon number |
2 |
| Exons |
121959811..121962448,121972155..121972886 |
| Genome context |
|
| Sequence |
000001 GAGACACACT ACAACAGGAG AGGGAGCAAG CGCGAGAGGA TATTAGAAGA GAGGCTTGTC TCCAAGATAT GGAAGGAAGT 000080 000081 GAGAAATGAC AGGGCTGCAA GCTTTGTATG TAGGAGCCCG GCAGGGCGGG GGAGCGGCGA GGAGAGCCAA GTGGATTCTC 000160 000161 AGAAAAGGGG GGAAGCCATC GAAGAGCTAA AGGTGATTAG AGGGGGATAT TGATTTCTTA TTCTGCCAGA GATTTAAGCA 000240 000241 GGCATGCGAG GAATCTGCAC CATGGTTGGC AAAAAGAGAC CCGTTGCCTC CTGTAACCAG ACACTCAGGC TTTCCAGGAG 000320 000321 CCCAGGGAGC AAGCCGAGAA GAAAGGGGGC AGTGTGGTCT AGGAAAATTC AACTTGTCGC TGATTTGTGC CTGATGCCTG 000400 000401 CTGTCCGTCA GCAGCCTCCC TTACAATCTT TTTTTCTCTC TCTCCTTTTT TTTTCCTTGC CTTCTCCTTC TTCACTGAAG 000480 000481 CCTAGGGGAG CCAGTAAAGA TTAAATGTGC TTCTCAAAGG CAGCCACTTC ATGCTGCTAT GTCGAAAGGG CCATTATTAT 000560 000561 TATTATATTT TAATGGTAAA AGAGAAAAGG AGAGAGGTTG AGCGAGCGAG AGAGAAGCTA GGTGTGATGA TGACAGACTA 000640 000641 GCTTTTCTGA GAGGAAAAGG AAAAGGGAAG GGAGAGAAAA AGGAGAGCCT CTGAGCTCAA CGGAGGATTG TGCCTGAGAA 000720 000721 GAACCCACAG AGTTGTGTTG ATGTTCCTTT CAGCTGGTCC TATAGTACCC CTCCTCAGGA ATGTCTCCCC AGTGCAAGGA 000800 000801 CAAAGACTGA AGAGACTGCT ATATTGATGG ACTCTCAAGC CAACTATGAA GTTGAAACAA AGAAAGTGAT CACCTGAAGA 000880 000881 CACCTCCTCT GCTAAGAAAC ACCCCCAAAT TGTGCAGCTT CTGCCACTAG AACTCTCAGA ACAAGAGACA ATCTTTTCAA 000960 000961 GAAACAGAAA AACTCAATAA TGACATCTAG ATTTTCATGA GCCAAGAACT TTCCCTTCCT CATGTGTATT CCTCTGTTTG 001040 001041 TACTTAAATT CATGTGACAT TCATTTTTTT CCTAGTATGG ATATGCTTAT TAATGCACTT GTTTCAAAAT CCCAAATTGC 001120 001121 ACAAATGTGT TAATATTTTA AGAAACAAAA TGAATCCTAC AAGGAGAATG ATTTTTAGCC ACACATAGGG TTGGATCTTG 001200 001201 AGAGTGACCT ACAGAATAAA AGTACTTTTA AAATAAAGTA GTCAGAGGCT ATTCAAAGGG TAAAATAATC ATAGTACCAC 001280 001281 ATTGGTCCAC TTGACACTAA CCAATCGATC ATTTTTTTTT AATCAAGAAA GCTAGATTCT ATCAGATAAA ATCACTGCTT 001360 001361 CTAAAGAGTT TAAATCTAGT TAGAAAAAGT TATAGAAATG TTTGCAAAGA TAAGTAACAG ATAGAGTCAG TAGAGGATAA 001440 001441 GATCAAAAAC AAAACCAAGC AAAAGATGAG TTCAGGGGAG TTTGCCATCA AGTTGGCAAA ACTGACTTAC TTAGGGAAGA 001520 001521 AAGTTATAAA ACAGGAAAAT ATGAGATGAA CCTTGAGTGA TGTGGAAGAT TTAGATAAAT GGAAAGGAAG GAGAAAATGG 001600 001601 AGTTCTTTAG GTGGTTGTAA TTGGAGGAGG AAATGAATAC ACACATCTTG TTGACTTAAA CCCAGACATT CAGCAGCTCT 001680 001681 CTATACATAT CTGGAAAAGA CTGCACAGTC ACCTCCTGTC TCTCACCCCA GGTATTACTT AGAATTATTA TCATATTTCC 001760 001761 CTTCCTTTAA AGTAAGTAAG GGTGATTGGT GACAATATGG AGAACTATGA TTTTTCCATT AACCTAATAA TAATTGGTAT 001840 001841 TTATTGAGTT CTGTTAAGCA TTTTACATAT TAACTCACTT AAGCCTTTCA ACAGCCTTGC AAAATAGGTA TTATTATCCC 001920 001921 CATTTTACAG GCAAGAAAAC TGAGGTTTAA GTAACTTGCC GAAGTGCCAT ATACAGGGCT CACATTCAGT ATTGCAGTTG 002000 002001 C |