Difference between revisions of "DACOR1"
Chunlei Yu (talk | contribs) (Created page with "==Annotated Information== ===Approved Symbol=== DACOR1 ===Approved Name=== DNMT1-associated colon cancer repressed lncRNA 1 ===Previous Symbols=== ===Synonyms=== TCONS_000232...") |
Chunlei Yu (talk | contribs) |
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===pubmed IDs=== | ===pubmed IDs=== | ||
26307088 | 26307088 | ||
| + | |||
| + | ===Disease=== | ||
| + | * colon cancer<ref name="ref1" /> | ||
| + | |||
| + | ===Function=== | ||
| + | DACOR1 induction resulted in down-regulation of Cystathionine β-synthase, which is known to lead to increased levels of S-adenosyl methionine-the key methyl donor for DNA methylation. <ref name="ref1" /> | ||
| + | |||
| + | The deregulation of DNMT1-associated lncRNAs contributes to aberrant DNA methylation and gene expression during colon tumorigenesis. | ||
| + | |||
| + | ===Expression=== | ||
| + | DACOR1 (DNMT1-associated Colon Cancer Repressed lncRNA 1), shows high, tissue-specific expression in the normal colon (including colon crypts) but was repressed in a panel of colon tumors and patient-derived colon cancer cell lines. <ref name="ref1" /> | ||
| + | |||
| + | ===Labs working on this lncRNA=== | ||
| + | * Department of Genetics and Genome Sciences, Department of Biochemistry.<ref name="ref1" /> | ||
| + | ===Reference=== | ||
| + | <references> | ||
| + | <ref name="ref1">Merry CR, Forrest ME, Sabers JN, Beard L, Gao XH, Hatzoglou M, et al. DNMT1-associated long non-coding RNAs regulate global gene expression and DNA methylation in colon cancer[J]. Human molecular genetics. 2015,24(21):6240-53.</ref>(1) | ||
| + | </references> | ||
Latest revision as of 03:07, 1 July 2016
Contents
Annotated Information
Approved Symbol
DACOR1
Approved Name
DNMT1-associated colon cancer repressed lncRNA 1
Previous Symbols
Synonyms
TCONS_00023265
Chromosome
15q22.33
OMIM ID
_
Ensembl ID
_
pubmed IDs
26307088
Disease
- colon cancer[1]
Function
DACOR1 induction resulted in down-regulation of Cystathionine β-synthase, which is known to lead to increased levels of S-adenosyl methionine-the key methyl donor for DNA methylation. [1]
The deregulation of DNMT1-associated lncRNAs contributes to aberrant DNA methylation and gene expression during colon tumorigenesis.
Expression
DACOR1 (DNMT1-associated Colon Cancer Repressed lncRNA 1), shows high, tissue-specific expression in the normal colon (including colon crypts) but was repressed in a panel of colon tumors and patient-derived colon cancer cell lines. [1]
Labs working on this lncRNA
- Department of Genetics and Genome Sciences, Department of Biochemistry.[1]
