Difference between revisions of "HCCAT5"
| Line 16: | Line 16: | ||
===pubmed IDs=== | ===pubmed IDs=== | ||
20130911, 23314567 | 20130911, 23314567 | ||
| + | |||
| + | ===Diseases=== | ||
| + | * Hepatocellular carcinoma | ||
| + | |||
| + | ===Characteristics=== | ||
| + | The ORF of the HTA gene encoded a protein of 92 amino acids with an estimated molecular weight of 10.2 kDa.<ref name="ref2" /> | ||
| + | [[File: HCCAT5.jpg|right|thumb|400px|'''Alternative splicing of the HTA gene''' <ref name="ref2" />.]] | ||
===Functions=== | ===Functions=== | ||
HTA could play important roles in Hepatocellular carcinoma(HCC) development and progression and can be a promising molecular target for the development of new diagnostic and therapeutic strategies for HCC.<ref name="ref1" /> | HTA could play important roles in Hepatocellular carcinoma(HCC) development and progression and can be a promising molecular target for the development of new diagnostic and therapeutic strategies for HCC.<ref name="ref1" /> | ||
| + | |||
| + | Overexpression of the HTA gene in the hepatic cell line QSG-7701 via stable transfection can promote its proliferation rate and colony forming ability and change the cell cycle distribution of the cell lines.<ref name="ref2" /> | ||
===Expression=== | ===Expression=== | ||
| − | The primer designed for HTA is described as the following: HTA of 607 bp, | + | The primer designed for HTA is described as the following: HTA of 607 bp, 5-GGCTTACACATGCTCTTGCT-3, (sense) and 5-GCCGAGTTCACTCATCCTTCT-3 (antisense);<ref name="ref1" /> |
HTA was highly expressed in hepatocellular carcinoma line HepG2, but was not detected in other cell lines.<ref name="ref1" /> | HTA was highly expressed in hepatocellular carcinoma line HepG2, but was not detected in other cell lines.<ref name="ref1" /> | ||
| − | |||
| − | |||
===Sequence=== | ===Sequence=== | ||
| Line 33: | Line 40: | ||
==Labs working on this lncRNA== | ==Labs working on this lncRNA== | ||
* Tumor Immunobiology Laboratory of Cancer Research Institute,Central South University, 410078 Changsha, Hunan, China <ref name="ref1" />. | * Tumor Immunobiology Laboratory of Cancer Research Institute,Central South University, 410078 Changsha, Hunan, China <ref name="ref1" />. | ||
| + | * Tumor Immunobiology Laboratory of Cancer Research Institute,Central South University, 110 Xiangya Road, Changsha, Hunan 410078.<ref name="ref2" /> | ||
==References== | ==References== | ||
<references> | <references> | ||
<ref name="ref1">Yan L,Y. L, Fj.G, Miao Dai, Jj.Wang, Jinyue.Hu and Guancheng Li.(2010) Identification of HTA as a novel-specific marker for human hepatocellular carcinoma.J Cancer Res Clin Oncol,136:1187–1192.</ref>(1) | <ref name="ref1">Yan L,Y. L, Fj.G, Miao Dai, Jj.Wang, Jinyue.Hu and Guancheng Li.(2010) Identification of HTA as a novel-specific marker for human hepatocellular carcinoma.J Cancer Res Clin Oncol,136:1187–1192.</ref>(1) | ||
| + | <ref name="ref2">Liu, Y., Y. Zhao, Q. Ju, L. Chen, F. Li, G. Zhou, P. Xie, G. Li, and Y. Li. "Molecular Clone and Functional Study of a Novel Hepatoma Associated Gene." Int J Oncol 42, no. 3 (2013): 1105-12.</ref>(2) | ||
</references> | </references> | ||
Revision as of 03:13, 17 September 2016
Contents
Annotated Information
Approved Symbol
HCCAT5
Approved Name
hepatocellular carcinoma associated transcript 5 (non-protein coding)
Synonyms
HTA, FJ222407
Chromosome
16q22.3
RefSeq ID
NR_027756
OMIM ID
615613
Ensembl ID
ENSG00000260880
pubmed IDs
20130911, 23314567
Diseases
- Hepatocellular carcinoma
Characteristics
The ORF of the HTA gene encoded a protein of 92 amino acids with an estimated molecular weight of 10.2 kDa.[1]
Alternative splicing of the HTA gene [1].
Functions
HTA could play important roles in Hepatocellular carcinoma(HCC) development and progression and can be a promising molecular target for the development of new diagnostic and therapeutic strategies for HCC.[2]
Overexpression of the HTA gene in the hepatic cell line QSG-7701 via stable transfection can promote its proliferation rate and colony forming ability and change the cell cycle distribution of the cell lines.[1]
Expression
The primer designed for HTA is described as the following: HTA of 607 bp, 5-GGCTTACACATGCTCTTGCT-3, (sense) and 5-GCCGAGTTCACTCATCCTTCT-3 (antisense);[2] HTA was highly expressed in hepatocellular carcinoma line HepG2, but was not detected in other cell lines.[2]
Sequence
>gi|238859661|ref|NR_027756.1| Homo sapiens hepatocellular carcinoma associated transcript 5 (non-protein coding) (HCCAT5), long non-coding RNA
000001 AAGTTTAAGA CAGCCTGGTG AGGCCCAGAG CCTCACCAGT CCCCCAGAAA ACGGAGTATT GTTTCCATCC AAACCTTGCA 000080
000081 CTGAAAGGAG CCTGTCAGCA GGAAGTGACC TCGTGAGACA ACTGTGGGGA GAGCAAAGGG CCGGGGAGAG AAAGGCCTCA 000160
000161 TTCTCACTGC AAACAGGAAA AGGAAAGAGA AAAAGCAAGC TCTGTCTCCA CACAAGGTTT GCTGGGCTGG CTATGAACTG 000240
000241 TTCCAGTACG TTCCATCAAA TAGACGCCTT CATAGAATCA AGCCGAGCGC GAACGCCGTG TCTGGGGCTC CCACTCCCGG 000320
000321 GACACACACG CGGGCTGGCT TACACATGCT CTTGCTCTCT CGCGCTCTGG GAGAGCGCTT ATATGGGCTT CATGAGGCTA 000400
000401 AGTAATAAAC ACTTTGTCTT CACCCTGCTA TTTATGGGTT GCTTGGGGCA TCCTGTGCTC TCCACTGCCC TTACCTGAAC 000480
000481 AGACGGCTCA TGCAGACCCG GAGTTTAATA GGGACAACAG TAAATCTGAG AGGCTGTGTG TGTCCCACGC GCTCCTGTTT 000560
000561 TCCCAGCCAC CCATGCTAGT TGCAGAGAAA AGCCAACCTG TATCCCTTCG TTTATGCTCT GTGTGCCCTT CCTGGAGAGA 000640
000641 TCCCTTCATT CTTCAGCAAT GGATCAAAGA ACTCTGAAAA CAAGAACAAC CCCGACAGCT GCAAACCACG AGCCCTCACC 000720
000721 TCCAGCAGAG GTTTTCGGGA AACTCTGGAC GACCACGCGC ATGCAGAGGG CTCTCAGAGC TTCCAGGTCC TGTAAGAAGA 000800
000801 GATGGAGTCA TAGCTGCGCC CTGTCCACTC TCGGGCTGTC ACACAAGCCT GGAGCCCAGC CATTTCTCGG CCTTGTCTTC 000880
000881 ATCTTGGGCT AACCGGTCGT CTCCTGCAAA CAGACAGCAC GGAGAAGGAT GAGTGAACTC GGCCTCTCCC CACAGAATAC 000960
000961 AGTTCGCCAT TACAGCGCTG ATTAAATACA GGACATTATC TCACCATAAT GCCCTCCTGG CGGCGTTCCC AGGAAAATTC 001040
001041 TAACTAATCA TAAAAATAGA AAGAAAAACG CAACCTAAAA AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA AAAA
000081 CTGAAAGGAG CCTGTCAGCA GGAAGTGACC TCGTGAGACA ACTGTGGGGA GAGCAAAGGG CCGGGGAGAG AAAGGCCTCA 000160
000161 TTCTCACTGC AAACAGGAAA AGGAAAGAGA AAAAGCAAGC TCTGTCTCCA CACAAGGTTT GCTGGGCTGG CTATGAACTG 000240
000241 TTCCAGTACG TTCCATCAAA TAGACGCCTT CATAGAATCA AGCCGAGCGC GAACGCCGTG TCTGGGGCTC CCACTCCCGG 000320
000321 GACACACACG CGGGCTGGCT TACACATGCT CTTGCTCTCT CGCGCTCTGG GAGAGCGCTT ATATGGGCTT CATGAGGCTA 000400
000401 AGTAATAAAC ACTTTGTCTT CACCCTGCTA TTTATGGGTT GCTTGGGGCA TCCTGTGCTC TCCACTGCCC TTACCTGAAC 000480
000481 AGACGGCTCA TGCAGACCCG GAGTTTAATA GGGACAACAG TAAATCTGAG AGGCTGTGTG TGTCCCACGC GCTCCTGTTT 000560
000561 TCCCAGCCAC CCATGCTAGT TGCAGAGAAA AGCCAACCTG TATCCCTTCG TTTATGCTCT GTGTGCCCTT CCTGGAGAGA 000640
000641 TCCCTTCATT CTTCAGCAAT GGATCAAAGA ACTCTGAAAA CAAGAACAAC CCCGACAGCT GCAAACCACG AGCCCTCACC 000720
000721 TCCAGCAGAG GTTTTCGGGA AACTCTGGAC GACCACGCGC ATGCAGAGGG CTCTCAGAGC TTCCAGGTCC TGTAAGAAGA 000800
000801 GATGGAGTCA TAGCTGCGCC CTGTCCACTC TCGGGCTGTC ACACAAGCCT GGAGCCCAGC CATTTCTCGG CCTTGTCTTC 000880
000881 ATCTTGGGCT AACCGGTCGT CTCCTGCAAA CAGACAGCAC GGAGAAGGAT GAGTGAACTC GGCCTCTCCC CACAGAATAC 000960
000961 AGTTCGCCAT TACAGCGCTG ATTAAATACA GGACATTATC TCACCATAAT GCCCTCCTGG CGGCGTTCCC AGGAAAATTC 001040
001041 TAACTAATCA TAAAAATAGA AAGAAAAACG CAACCTAAAA AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA AAAA
Labs working on this lncRNA
- Tumor Immunobiology Laboratory of Cancer Research Institute,Central South University, 410078 Changsha, Hunan, China [2].
- Tumor Immunobiology Laboratory of Cancer Research Institute,Central South University, 110 Xiangya Road, Changsha, Hunan 410078.[1]
References
- ↑ 1.0 1.1 1.2 1.3 Liu, Y., Y. Zhao, Q. Ju, L. Chen, F. Li, G. Zhou, P. Xie, G. Li, and Y. Li. "Molecular Clone and Functional Study of a Novel Hepatoma Associated Gene." Int J Oncol 42, no. 3 (2013): 1105-12.
- ↑ 2.0 2.1 2.2 2.3 Yan L,Y. L, Fj.G, Miao Dai, Jj.Wang, Jinyue.Hu and Guancheng Li.(2010) Identification of HTA as a novel-specific marker for human hepatocellular carcinoma.J Cancer Res Clin Oncol,136:1187–1192.
