Difference between revisions of "HELLPAR"
Chunlei Yu (talk | contribs) (Created page with "==Annotated Information== ===Approved Symbol=== HELLPAR ===Approved Name=== HELLP associated long non-coding RNA ===Previous Symbols=== ===Synonyms=== LINC-HELLP ===Chromosom...") |
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===Approved Name=== | ===Approved Name=== | ||
HELLP associated long non-coding RNA | HELLP associated long non-coding RNA | ||
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===Synonyms=== | ===Synonyms=== | ||
LINC-HELLP | LINC-HELLP | ||
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===pubmed IDs=== | ===pubmed IDs=== | ||
23093777 | 23093777 | ||
| + | ===Diseases=== | ||
| + | * HELLP syndrome | ||
| + | |||
| + | ===Characteristics=== | ||
| + | The HELLP locus is in an intergenic region on 12q23.2 between PMCH and IGF1.And the HELLP associated long non-coding RNA is a transcript of 205,012 bases. <ref name="ref1" /> | ||
| + | |||
| + | ===Functions=== | ||
| + | Results of whole-genome RNA-Seq indicated that the HELLP lincRNA is involved in 1 or more processes in the cell cycle, in which siRNA-mediated knockdown of the transcript leads to reduced activity of the G2/M phase of the cell cycle, while the G1/S phase shows an increase in activity.<ref name="ref1" /> | ||
| + | |||
| + | ===Expression=== | ||
| + | By FISH, expression was found to be nuclear, perinuclear, and cytoplasmic, both in vitro — in the extravillous trophoblast cell line (SGHPL-5) used for its identification-and in vivo (i.e., first trimester placenta tissue),whereas no signal was detected using a sense probe as negative control.<ref name="ref1" /> | ||
| + | |||
| + | ==Labs working on this lncRNA== | ||
| + | * Department of Clinical Chemistry and Institute for Cardiovascular Research, VU University Medical Center, Amsterdam, The Netherlands.<ref name="ref1" />. | ||
| + | |||
| + | ==References== | ||
| + | <references> | ||
| + | <ref name="ref1"> van Dijk, M., H. K. Thulluru, J. Mulders, O. J. Michel, A. Poutsma, S. Windhorst, G. Kleiverda, D. Sie, A. M. Lachmeijer, and C. B. Oudejans. "Hellp Babies Link a Novel Lincrna to the Trophoblast Cell Cycle." J Clin Invest 122, no. 11 (2012): 4003-11.</ref>(1) | ||
| + | </references> | ||
Revision as of 06:42, 17 September 2016
Contents
Annotated Information
Approved Symbol
HELLPAR
Approved Name
HELLP associated long non-coding RNA
Synonyms
LINC-HELLP
Chromosome
12q23.2
OMIM ID
614985
Ensembl ID
ENSG00000281344
pubmed IDs
23093777
Diseases
- HELLP syndrome
Characteristics
The HELLP locus is in an intergenic region on 12q23.2 between PMCH and IGF1.And the HELLP associated long non-coding RNA is a transcript of 205,012 bases. [1]
Functions
Results of whole-genome RNA-Seq indicated that the HELLP lincRNA is involved in 1 or more processes in the cell cycle, in which siRNA-mediated knockdown of the transcript leads to reduced activity of the G2/M phase of the cell cycle, while the G1/S phase shows an increase in activity.[1]
Expression
By FISH, expression was found to be nuclear, perinuclear, and cytoplasmic, both in vitro — in the extravillous trophoblast cell line (SGHPL-5) used for its identification-and in vivo (i.e., first trimester placenta tissue),whereas no signal was detected using a sense probe as negative control.[1]
Labs working on this lncRNA
- Department of Clinical Chemistry and Institute for Cardiovascular Research, VU University Medical Center, Amsterdam, The Netherlands.[1].
