Difference between revisions of "FLNC-AS1"

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FLNC-AS1:FLNC antisense RNA 1
 
FLNC-AS1:FLNC antisense RNA 1
  
ENST00000447565 <ref name="ref1" />
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ENST00000469965<ref name="ref1" />  
 
===Characteristics===
 
===Characteristics===
ENST00000447565 is a LIF (leukemia inhibitor factor) natural antisense lncRNA. <ref name="ref1" />
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ENST00000469965 is a FLNC(filamin C) natural antisense lncRNA.<ref name="ref1" />  
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 +
===Cellular Localization===
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===Function===
 
===Function===
Lnc-LIF-AS can regulate the stability of LIF mRNA by over-lapping a 3′-UTR of LIF mRNA which might contribute to inhibit the degradation of LIF mRNA mediated by other RNAs.<ref name="ref1" />
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===Regulation===
 
===Regulation===
The expression ofΔNp63α can directly inhibitLIF mRNA transcription and decrease LIF mRNA stability by suppressing the expression of Lnc-LIF-AS.<ref name="ref1" />
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===Diseases===
 
===Diseases===
 
Cervical squamous cancers<ref name="ref1" />  
 
Cervical squamous cancers<ref name="ref1" />  
 
===Expression===
 
===Expression===
ENST00000447565 is significantly downregulated expression  in SiHa/ΔNp63αstable cell lines.  
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ENST00000469965 is significantly downregulated expression  in SiHa/ΔNp63αstable cell lines.  
In addition, Lnc-LIF-AS is also shown gradually up-regulated with the increase of ΔNp63α siRNAs. <ref name="ref1" />
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===Sequence===
  
 
==Labs working on this lncRNA==
 
==Labs working on this lncRNA==

Revision as of 02:45, 13 August 2017

Annotated Information

Name

FLNC-AS1:FLNC antisense RNA 1

ENST00000469965[1]

Characteristics

ENST00000469965 is a FLNC(filamin C) natural antisense lncRNA.[1]

Cellular Localization

Function

Regulation

Diseases

Cervical squamous cancers[1]

Expression

ENST00000469965 is significantly downregulated expression in SiHa/ΔNp63αstable cell lines.

Sequence

Labs working on this lncRNA

  • Department of Obstetrics and Gynecology, Anhui Provincial Hospital, Anhui Medical University, Hefei 230001, China.

References

  1. 1.0 1.1 1.2 Qian L, Xu F, Wang X, Jiang M, Wang J, Song W, Wu D, Shen Z, Feng D, Ling B, Cheng Y, Xiao W, Shan G, Zhou Y. LncRNA expression profile of ΔNp63α in cervical squamous cancers and its suppressive effects on LIF expression. Cytokine. 2017 Aug;96:114-122.