Difference between revisions of "LIF-AS1"
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ENST00000447565 <ref name="ref1" /> | ENST00000447565 <ref name="ref1" /> | ||
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===Characteristics=== | ===Characteristics=== | ||
| − | ENST00000447565 is a LIF (leukemia inhibitor factor) natural antisense lncRNA | + | ENST00000447565 is a LIF (leukemia inhibitor factor) natural antisense lncRNA <ref name="ref1" />. |
===Function=== | ===Function=== | ||
| − | Lnc-LIF-AS can regulate the stability of LIF mRNA by over-lapping a 3′-UTR of LIF mRNA which might contribute to | + | Lnc-LIF-AS can regulate the stability of LIF mRNA by over-lapping a 3′-UTR of LIF mRNA, which might contribute to inhibiting the degradation of LIF mRNA mediated by other RNAs <ref name="ref1" />. |
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===Regulation=== | ===Regulation=== | ||
| − | The expression ofΔNp63α can | + | The expression ofΔNp63α can suppress the expression of Lnc-LIF-AS to inhibit LIF mRNA transcription and decrease LIF mRNA stability <ref name="ref1" />. |
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| + | ===Expression=== | ||
| + | ENST00000447565 is significantly downregulated in SiHa/ΔNp63αstable cell lines, and shows gradual up-regulation with the increase of ΔNp63α siRNAs <ref name="ref1" />. | ||
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===Diseases=== | ===Diseases=== | ||
| − | Cervical squamous cancers | + | Cervical squamous cancers <ref name="ref1" /> |
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==Labs working on this lncRNA== | ==Labs working on this lncRNA== | ||
Latest revision as of 03:16, 30 August 2017
Contents
Annotated Information
Name
LIF-AS1:LIF antisense RNA 1
ENST00000447565 [1]
Characteristics
ENST00000447565 is a LIF (leukemia inhibitor factor) natural antisense lncRNA [1].
Function
Lnc-LIF-AS can regulate the stability of LIF mRNA by over-lapping a 3′-UTR of LIF mRNA, which might contribute to inhibiting the degradation of LIF mRNA mediated by other RNAs [1].
Regulation
The expression ofΔNp63α can suppress the expression of Lnc-LIF-AS to inhibit LIF mRNA transcription and decrease LIF mRNA stability [1].
Expression
ENST00000447565 is significantly downregulated in SiHa/ΔNp63αstable cell lines, and shows gradual up-regulation with the increase of ΔNp63α siRNAs [1].
Diseases
Cervical squamous cancers [1]
Labs working on this lncRNA
- Department of Obstetrics and Gynecology, Anhui Provincial Hospital, Anhui Medical University, Hefei 230001, China.
