Difference between revisions of "SATB2-AS1"
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SATB2-AS1:SATB2 antisense RNA 1 | SATB2-AS1:SATB2 antisense RNA 1 | ||
| − | AC017096.1<ref name="ref1" /> | + | AC017096.1 <ref name="ref1" /> |
===Characteristics=== | ===Characteristics=== | ||
| − | The LncRNA SATB2-AS1 is located at chromosome 2, and is oriented in antisense direction with respect to the SATB2 gene and is complimentary for about 3197 nucleotides | + | The LncRNA SATB2-AS1 is located at chromosome 2, and is oriented in antisense direction with respect to the SATB2 gene and is complimentary for about 3197 nucleotides <ref name="ref1" />. |
===Cellular Localization=== | ===Cellular Localization=== | ||
| − | SATB2-AS1 lncRNA in two osteosarcoma cell lines is present in both the cytoplasmic and nuclear fraction | + | SATB2-AS1 lncRNA in two osteosarcoma cell lines is present in both the cytoplasmic and nuclear fraction <ref name="ref1" />. |
===Function=== | ===Function=== | ||
| − | In vitro gain and loss of function approaches | + | SATB2-AS1 affects the translational expression of SATB2 gene. In vitro, gain and loss of function approaches demonstrate that SATB2-AS1 regulates cell cycle, cell proliferation, and cell growth <ref name="ref1" />. |
| + | |||
| + | ===Expression=== | ||
| + | SATB2-AS1(AC017096.1) is increased in the osteosarcoma compared to paired non-tumor tissues, and SATB2-AS1 is significantly up-regulated in the metastatic tumors compared to non-metastatic tumors <ref name="ref1" />. | ||
===Diseases=== | ===Diseases=== | ||
| − | Osteosarcoma | + | Osteosarcoma <ref name="ref1" /> |
| − | |||
| − | |||
| − | |||
===Sequence=== | ===Sequence=== | ||
Latest revision as of 07:38, 1 September 2017
Contents
Annotated Information
Name
SATB2-AS1:SATB2 antisense RNA 1
AC017096.1 [1]
Characteristics
The LncRNA SATB2-AS1 is located at chromosome 2, and is oriented in antisense direction with respect to the SATB2 gene and is complimentary for about 3197 nucleotides [1].
Cellular Localization
SATB2-AS1 lncRNA in two osteosarcoma cell lines is present in both the cytoplasmic and nuclear fraction [1].
Function
SATB2-AS1 affects the translational expression of SATB2 gene. In vitro, gain and loss of function approaches demonstrate that SATB2-AS1 regulates cell cycle, cell proliferation, and cell growth [1].
Expression
SATB2-AS1(AC017096.1) is increased in the osteosarcoma compared to paired non-tumor tissues, and SATB2-AS1 is significantly up-regulated in the metastatic tumors compared to non-metastatic tumors [1].
Diseases
Osteosarcoma [1]
Sequence
>NR_026830.1 Homo sapiens SATB2 antisense RNA 1 (SATB2-AS1), long non-coding RNA
000001 ACTTGAAACA TTCTGAGTGT GCCTGCAGTA GGGTCTCAGA GGAGTTGCTC TGAAAGCTGT TGAGAGCAGC CACCTTTGCT 000080
000081 GTCACTGAGA GCTTGGCAGG GTCAGCTCTG GTGGGCCGTT TGCACCCAGG CTCTGATGGC ACCAGGATGG CTTCCTGCAA 000160
000161 CCCGGAACCT GATCCTGGCC CCCGGCAGAG CATAAGGGCC CGAGGCCAGG GACCTAGAGG CCGGACCAAG TTCGCGCGAG 000240
000241 GTGTTCACAG CCTAGGCGCC CCGGGCTTGG CTTCGTACTC TGCAACAAGC CAAGCTCCCT TGCCACGAGT ATATCAGCAA 000320
000321 CTTCAGAAAT AAACACCAGC GAAACCCCTT CCCACATTAG CTTGTTGCTG TGCTACTGAC ACTGGGCTTA GTCGATGTTC 000400
000401 ACACCTATTA CATTTTTCCG GAAAGTGGGA GGAGCAGGGG GTAGAGAAAG CTGTGTGTAT TGAGGGAAGG GGAGATGTGT 000480
000481 GCAACACCTT CCAGAAAAAT GGGGAGGTAG TTTAGAAAGT TTTTCTCTGT AACAGCACAG CTTCTGAGAA GGCAGAGAGA 000560
000561 AGAAAGCAGA CAGGAAACGA ATCCCTTCCT CCTCTCCCCT TTACCCCCTT CCTTCACTCC CTAGACCAAG CTGGTCACCC 000640
000641 GGCTGGGAAT CAAGATTGTG TGGCTGGGAA GACACCAGTC TCTGTGCTCG GGTTCAGCCC AGTCGGGCAA GAAAGTCTGG 000720
000721 GCAGCTGGAG AAGGTCGTCA CAGTCTCCCG TGGAATCTTG TTGCCTGAGA GCCCCATAAC GGAAAGGGCT AAGACGACTC 000800
000801 TTCCACACAC AGGTCGCAGC CCCTGCCGCG GAGGATCCCC AGGAAGATGC TGGGGACGCT CTGAGCATCG GCCTTTCTTT 000880
000881 ACCCCCGACT CCCTGGAGCT TGGTCTCGGG ATGCCAACTT GGGGCACGGA GGCGACGGGC TGCTCCGAAG CTGGAGGGTT 000960
000961 TCTGCTTGGG TCAGAGGGAT CACGACCTCA GCAGAGCCAG GAGAGGTTGG GTGACACCCA CTGCGTATTG CACTTGACTC 001040
001041 AAAACTGCCC TCGGCCTGCG GAAGAGGCGA GGGCAAGAAG CCTGGTGGCG GGTCAAACCT TCACCCTATT ATTTTCTATC 001120
001121 ATTTTTTATG CCCATATATT TGTTAAATGT ATGGCTGCTA TACACCAACA GCTTATTCTA CAAGAAGTGC CCCCGAGGAG 001200
001201 GATTGGGTTA AGCTTTGCAA ATTTGGCTTC CCAGGTAATG CGCTTCATTA TTCTGCTCCC GACTTACCCA CCACACCAGT 001280
001281 GGGTACCCGG AGCAGCACCC ACTTGGCAGA ACTGATGACT GCTTGGGCCC AGCGGAGTGC GCATTGCGCT AACACGCGCA 001360
001361 CGGGAATTGC ACCCTTGCCG GAGCCTCCGC ACCGTGCGCC CTTCAAAGAG CTGGCGACCC CGCTCACGTG TAAGCAACCT 001440
001441 CCCACTTTGA AACTAATTCG CACCCGGGTC TTTCACCCCA AAGGACTTTG CTGCGGACGC TGCTCTGACC CAAGACGCGG 001520
001521 GAGAGAAGTC CCAAAGGCTA CAGCCAGGGG CTGGGGGACT CCTCTGCTCA CCTTAGTCCT TGATTTCGAA GGCCCCAATT 001600
001601 AACTATCTGT TGTGTCAGAA TCGGCGAGTG CAAAGTAGCT GCGCCCCGCT GACGCGCTCT CTCCTGGGTC CGGGTATCCC 001680
001681 AGGGCATCCG GAGCTGGGGA GGGTTGTGCG GACTACCCAA GGCACGCGCA GATACCGGGC AGGGAAGAAG GGCTCCGTGT 001760
001761 TCCAAGGATG GTCGTTTACC TCTCCTGAGA TCAGCCCTAA TCCCTTGGTA ACTTAAGCGC CTCTGAACTC GGGGAGCGCT 001840
001841 TGGTGGGGCG CCTCCCTGCA TCCACCCCTA CCCCTGGCTC CTTCCCAGGC CCAGCATCTT TCCCACCATT CTCACCCCCA 001920
001921 CCACCCCCAC GGCCCCGCCC GTTTAGAGGC GTGCGGTGGG CACTTGGTTT ACAGAACCGG CGTTTCAGAT GTTTATTTGC 002000
002001 A
000081 GTCACTGAGA GCTTGGCAGG GTCAGCTCTG GTGGGCCGTT TGCACCCAGG CTCTGATGGC ACCAGGATGG CTTCCTGCAA 000160
000161 CCCGGAACCT GATCCTGGCC CCCGGCAGAG CATAAGGGCC CGAGGCCAGG GACCTAGAGG CCGGACCAAG TTCGCGCGAG 000240
000241 GTGTTCACAG CCTAGGCGCC CCGGGCTTGG CTTCGTACTC TGCAACAAGC CAAGCTCCCT TGCCACGAGT ATATCAGCAA 000320
000321 CTTCAGAAAT AAACACCAGC GAAACCCCTT CCCACATTAG CTTGTTGCTG TGCTACTGAC ACTGGGCTTA GTCGATGTTC 000400
000401 ACACCTATTA CATTTTTCCG GAAAGTGGGA GGAGCAGGGG GTAGAGAAAG CTGTGTGTAT TGAGGGAAGG GGAGATGTGT 000480
000481 GCAACACCTT CCAGAAAAAT GGGGAGGTAG TTTAGAAAGT TTTTCTCTGT AACAGCACAG CTTCTGAGAA GGCAGAGAGA 000560
000561 AGAAAGCAGA CAGGAAACGA ATCCCTTCCT CCTCTCCCCT TTACCCCCTT CCTTCACTCC CTAGACCAAG CTGGTCACCC 000640
000641 GGCTGGGAAT CAAGATTGTG TGGCTGGGAA GACACCAGTC TCTGTGCTCG GGTTCAGCCC AGTCGGGCAA GAAAGTCTGG 000720
000721 GCAGCTGGAG AAGGTCGTCA CAGTCTCCCG TGGAATCTTG TTGCCTGAGA GCCCCATAAC GGAAAGGGCT AAGACGACTC 000800
000801 TTCCACACAC AGGTCGCAGC CCCTGCCGCG GAGGATCCCC AGGAAGATGC TGGGGACGCT CTGAGCATCG GCCTTTCTTT 000880
000881 ACCCCCGACT CCCTGGAGCT TGGTCTCGGG ATGCCAACTT GGGGCACGGA GGCGACGGGC TGCTCCGAAG CTGGAGGGTT 000960
000961 TCTGCTTGGG TCAGAGGGAT CACGACCTCA GCAGAGCCAG GAGAGGTTGG GTGACACCCA CTGCGTATTG CACTTGACTC 001040
001041 AAAACTGCCC TCGGCCTGCG GAAGAGGCGA GGGCAAGAAG CCTGGTGGCG GGTCAAACCT TCACCCTATT ATTTTCTATC 001120
001121 ATTTTTTATG CCCATATATT TGTTAAATGT ATGGCTGCTA TACACCAACA GCTTATTCTA CAAGAAGTGC CCCCGAGGAG 001200
001201 GATTGGGTTA AGCTTTGCAA ATTTGGCTTC CCAGGTAATG CGCTTCATTA TTCTGCTCCC GACTTACCCA CCACACCAGT 001280
001281 GGGTACCCGG AGCAGCACCC ACTTGGCAGA ACTGATGACT GCTTGGGCCC AGCGGAGTGC GCATTGCGCT AACACGCGCA 001360
001361 CGGGAATTGC ACCCTTGCCG GAGCCTCCGC ACCGTGCGCC CTTCAAAGAG CTGGCGACCC CGCTCACGTG TAAGCAACCT 001440
001441 CCCACTTTGA AACTAATTCG CACCCGGGTC TTTCACCCCA AAGGACTTTG CTGCGGACGC TGCTCTGACC CAAGACGCGG 001520
001521 GAGAGAAGTC CCAAAGGCTA CAGCCAGGGG CTGGGGGACT CCTCTGCTCA CCTTAGTCCT TGATTTCGAA GGCCCCAATT 001600
001601 AACTATCTGT TGTGTCAGAA TCGGCGAGTG CAAAGTAGCT GCGCCCCGCT GACGCGCTCT CTCCTGGGTC CGGGTATCCC 001680
001681 AGGGCATCCG GAGCTGGGGA GGGTTGTGCG GACTACCCAA GGCACGCGCA GATACCGGGC AGGGAAGAAG GGCTCCGTGT 001760
001761 TCCAAGGATG GTCGTTTACC TCTCCTGAGA TCAGCCCTAA TCCCTTGGTA ACTTAAGCGC CTCTGAACTC GGGGAGCGCT 001840
001841 TGGTGGGGCG CCTCCCTGCA TCCACCCCTA CCCCTGGCTC CTTCCCAGGC CCAGCATCTT TCCCACCATT CTCACCCCCA 001920
001921 CCACCCCCAC GGCCCCGCCC GTTTAGAGGC GTGCGGTGGG CACTTGGTTT ACAGAACCGG CGTTTCAGAT GTTTATTTGC 002000
002001 A