Difference between revisions of "XACT"
| Line 4: | Line 4: | ||
===Approved Name=== | ===Approved Name=== | ||
X active specific transcript (non-protein coding) | X active specific transcript (non-protein coding) | ||
| − | |||
| − | |||
===Disease=== | ===Disease=== | ||
chromosome inactivation | chromosome inactivation | ||
| Line 16: | Line 14: | ||
===Ensembl ID=== | ===Ensembl ID=== | ||
ENSG00000241743 | ENSG00000241743 | ||
| + | ===Characteristics=== | ||
| + | XACT is a 251.8-kb transcription unit(112,983,323–113,235,148 bp) and locates on chromosome Xq23 between the protein-coding genes AMOT and HTR2C <ref name="ref1" />. | ||
| + | XACT is in an intergenic domain of 1.7 Mb <ref name="ref1" />. | ||
| + | |||
| + | ===Function=== | ||
| + | XACT has a unique role in the control of human XCI initiation <ref name="ref1" />. | ||
| + | [[File:Characterization of XACT, a long intergenic RNA that coats the active X chromosome in hESCs.jpg|right|thumb|400px|'''(a)Localization of XACT and XIST on the human X chromosome (b)RT-PCR analysis (c,d,e)FISH analysis (f) Three-dimensional model of the nuclear volumes occupied by XACT and XIST RNAs.'''<ref name="ref1" />]] | ||
| + | |||
| + | ===Cellular Location=== | ||
| + | It is polyadenylated and mostly nuclear. | ||
| + | |||
| + | ===Evolution=== | ||
| + | XACT is not conserved in mice <ref name="ref1" />. | ||
| + | |||
| + | ===Expression=== | ||
| + | XACT is expressed in both X chromosomes in humans but not in mice. And expression of XACT is restricted to pluripotent cells <ref name="ref1" />. | ||
| + | |||
===pubmed IDs=== | ===pubmed IDs=== | ||
23334669, 25921272 | 23334669, 25921272 | ||
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>gi|784642207|ref|NR_131204.1| Homo sapiens X active specific transcript (non-protein coding) (XACT), long non-coding RNA | >gi|784642207|ref|NR_131204.1| Homo sapiens X active specific transcript (non-protein coding) (XACT), long non-coding RNA | ||
<dnaseq>TTTGTGGATGAGTCAATGAAGAAACTTGTCAAAGCACTTCAATTAAAACACAGAAACTATAGAAAATCATCTGGTAAACATGCTGATGATGTCCTAAACCTGATCACTTGTCTCAAAATTTAGAAAGTTAATGGCTGAAGATTCAGCAGCCATTCTGAACTGGAAATTACATGTTAAGGCTGTTATAGAAGAAATAAAGAAATTAAATCTCTATGTCCCCAAGGTATCTCTATACCGGCCTGGAATGCCTATCTCCAAACCTCCTTTACATGAGACAGAAACAGCTTCTATCACCTTAAAATCTGTTACTTTAGGTTTTTTTCATTATGAGCAGCTAAAATGAATCTTACTTGATACAGTGTGAGTGTTCATGGATTAGGGCATTGTTTGATAAGAGGAGTAAGAAAAGAATATAAATTGTATTGGCCCTGATATGCCACAAACAATGAGGGCTGAAGCCAAATTAATCAAAGAATAAACTCAAATACAAAGAACAAAAAAAAAAAAAA</dnaseq> | <dnaseq>TTTGTGGATGAGTCAATGAAGAAACTTGTCAAAGCACTTCAATTAAAACACAGAAACTATAGAAAATCATCTGGTAAACATGCTGATGATGTCCTAAACCTGATCACTTGTCTCAAAATTTAGAAAGTTAATGGCTGAAGATTCAGCAGCCATTCTGAACTGGAAATTACATGTTAAGGCTGTTATAGAAGAAATAAAGAAATTAAATCTCTATGTCCCCAAGGTATCTCTATACCGGCCTGGAATGCCTATCTCCAAACCTCCTTTACATGAGACAGAAACAGCTTCTATCACCTTAAAATCTGTTACTTTAGGTTTTTTTCATTATGAGCAGCTAAAATGAATCTTACTTGATACAGTGTGAGTGTTCATGGATTAGGGCATTGTTTGATAAGAGGAGTAAGAAAAGAATATAAATTGTATTGGCCCTGATATGCCACAAACAATGAGGGCTGAAGCCAAATTAATCAAAGAATAAACTCAAATACAAAGAACAAAAAAAAAAAAAA</dnaseq> | ||
| + | |||
| + | ==References== | ||
| + | <references> | ||
| + | <ref name="ref1">Vallot, C., et al., XACT, a long noncoding transcript coating the active X chromosome in human pluripotent cells. Nat Genet, 2013. 45(3): p. 239-41. | ||
| + | </ref>(1) | ||
| + | </references> | ||
Revision as of 16:08, 23 September 2017
Contents
Annotated Information
Approved Symbol
XACT
Approved Name
X active specific transcript (non-protein coding)
Disease
chromosome inactivation
Chromosome
Xq23
RefSeq ID
NR_131204
OMIM ID
300901
Ensembl ID
ENSG00000241743
Characteristics
XACT is a 251.8-kb transcription unit(112,983,323–113,235,148 bp) and locates on chromosome Xq23 between the protein-coding genes AMOT and HTR2C [1]. XACT is in an intergenic domain of 1.7 Mb [1].
Function
XACT has a unique role in the control of human XCI initiation [1].
(a)Localization of XACT and XIST on the human X chromosome (b)RT-PCR analysis (c,d,e)FISH analysis (f) Three-dimensional model of the nuclear volumes occupied by XACT and XIST RNAs.[1]
Cellular Location
It is polyadenylated and mostly nuclear.
Evolution
XACT is not conserved in mice [1].
Expression
XACT is expressed in both X chromosomes in humans but not in mice. And expression of XACT is restricted to pluripotent cells [1].
pubmed IDs
23334669, 25921272
Sequence
>gi|784642207|ref|NR_131204.1| Homo sapiens X active specific transcript (non-protein coding) (XACT), long non-coding RNA
000001 TTTGTGGATG AGTCAATGAA GAAACTTGTC AAAGCACTTC AATTAAAACA CAGAAACTAT AGAAAATCAT CTGGTAAACA 000080
000081 TGCTGATGAT GTCCTAAACC TGATCACTTG TCTCAAAATT TAGAAAGTTA ATGGCTGAAG ATTCAGCAGC CATTCTGAAC 000160
000161 TGGAAATTAC ATGTTAAGGC TGTTATAGAA GAAATAAAGA AATTAAATCT CTATGTCCCC AAGGTATCTC TATACCGGCC 000240
000241 TGGAATGCCT ATCTCCAAAC CTCCTTTACA TGAGACAGAA ACAGCTTCTA TCACCTTAAA ATCTGTTACT TTAGGTTTTT 000320
000321 TTCATTATGA GCAGCTAAAA TGAATCTTAC TTGATACAGT GTGAGTGTTC ATGGATTAGG GCATTGTTTG ATAAGAGGAG 000400
000401 TAAGAAAAGA ATATAAATTG TATTGGCCCT GATATGCCAC AAACAATGAG GGCTGAAGCC AAATTAATCA AAGAATAAAC 000480
000481 TCAAATACAA AGAACAAAAA AAAAAAAAA
000081 TGCTGATGAT GTCCTAAACC TGATCACTTG TCTCAAAATT TAGAAAGTTA ATGGCTGAAG ATTCAGCAGC CATTCTGAAC 000160
000161 TGGAAATTAC ATGTTAAGGC TGTTATAGAA GAAATAAAGA AATTAAATCT CTATGTCCCC AAGGTATCTC TATACCGGCC 000240
000241 TGGAATGCCT ATCTCCAAAC CTCCTTTACA TGAGACAGAA ACAGCTTCTA TCACCTTAAA ATCTGTTACT TTAGGTTTTT 000320
000321 TTCATTATGA GCAGCTAAAA TGAATCTTAC TTGATACAGT GTGAGTGTTC ATGGATTAGG GCATTGTTTG ATAAGAGGAG 000400
000401 TAAGAAAAGA ATATAAATTG TATTGGCCCT GATATGCCAC AAACAATGAG GGCTGAAGCC AAATTAATCA AAGAATAAAC 000480
000481 TCAAATACAA AGAACAAAAA AAAAAAAAA
