Difference between revisions of "LINC01186"
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===Characteristics=== | ===Characteristics=== | ||
| − | LINC01186 is a ~600 nt long transcript, consisting of two exons, and originating from a locus of approximately 1.7 kb in the short arm of chromosome X | + | LINC01186 is a ~600 nt long transcript, consisting of two exons, and originating from a locus of approximately 1.7 kb in the short arm of chromosome X <ref name="ref1" />. |
===Cellular Localization=== | ===Cellular Localization=== | ||
| − | + | LINC01186 transcript is mainly located in the nucleus <ref name="ref1" />. | |
===Function=== | ===Function=== | ||
[[File:LINC01186-function.jpg|right|thumb|400px|'''''LINC01186'' inhibits migration, invasion and colony formation'''<ref name="ref1" />.]] | [[File:LINC01186-function.jpg|right|thumb|400px|'''''LINC01186'' inhibits migration, invasion and colony formation'''<ref name="ref1" />.]] | ||
| − | + | LINC01186, regulated by TGF-β/SMAD3, inhibits migration and invasion through Epithelial-Mesenchymal-Transition in lung cancer <ref name="ref1" />. Knocking-down LINC01186 promots cell migration and invasion, whereas, LINC01186 overexpression prevents cell metastasis <ref name="ref1" />. | |
===Regulation=== | ===Regulation=== | ||
| − | LINC01186 is regulated by SMAD3 | + | LINC01186 is regulated by TGF-β/SMAD3. The expression of LINC01186 is significantly decreased in A549 cells treated with TGF-β1 <ref name="ref1" />. |
| + | |||
===Expression=== | ===Expression=== | ||
| − | + | LINC01186 is stably down-regulated in lung cancer tissues compared with normal tissues <ref name="ref1" />. | |
| + | |||
===Diseases=== | ===Diseases=== | ||
Lung cancer <ref name="ref1" /> | Lung cancer <ref name="ref1" /> | ||
| + | |||
===Sequence=== | ===Sequence=== | ||
>NR_110388.1 Homo sapiens long intergenic non-protein coding RNA 1186 (LINC01186), long non-coding RNA | >NR_110388.1 Homo sapiens long intergenic non-protein coding RNA 1186 (LINC01186), long non-coding RNA | ||
| Line 37: | Line 40: | ||
==References== | ==References== | ||
<references> | <references> | ||
| − | <ref name="ref1"> | + | <ref name="ref1">Hao Y, Yang X, Zhang D, Luo J, Chen R. Long noncoding RNA LINC01186, regulated by TGF-β/SMAD3, inhibits migration and invasion through Epithelial-Mesenchymal-Transition in lung cancer. Gene. 2017 Apr 15;608:1-12.</ref> |
| − | Hao Y, Yang X, Zhang D, Luo J, Chen R. Long noncoding RNA LINC01186, regulated | ||
| − | by TGF-β/SMAD3, inhibits migration and invasion through | ||
| − | Epithelial-Mesenchymal-Transition in lung cancer. Gene. 2017 Apr 15;608:1-12. | ||
| − | </ref> | ||
</references> | </references> | ||
Latest revision as of 09:07, 28 September 2017
Contents
Annotated Information
Name
LINC01186:long intergenic non-protein coding RNA 1186
Characteristics
LINC01186 is a ~600 nt long transcript, consisting of two exons, and originating from a locus of approximately 1.7 kb in the short arm of chromosome X [1].
Cellular Localization
LINC01186 transcript is mainly located in the nucleus [1].
Function
LINC01186 inhibits migration, invasion and colony formation[1].
LINC01186, regulated by TGF-β/SMAD3, inhibits migration and invasion through Epithelial-Mesenchymal-Transition in lung cancer [1]. Knocking-down LINC01186 promots cell migration and invasion, whereas, LINC01186 overexpression prevents cell metastasis [1].
Regulation
LINC01186 is regulated by TGF-β/SMAD3. The expression of LINC01186 is significantly decreased in A549 cells treated with TGF-β1 [1].
Expression
LINC01186 is stably down-regulated in lung cancer tissues compared with normal tissues [1].
Diseases
Lung cancer [1]
Sequence
>NR_110388.1 Homo sapiens long intergenic non-protein coding RNA 1186 (LINC01186), long non-coding RNA
000001 AGGCTAACAG AAACCCAGCC CTGCCCACTG GGTGAAACTG CAAGTCGAGA GCGTGGGAAA CCAGCAAGTT GAGAGAGGAT 000080
000081 CCAGAAGTAA CCCCTTCTAA AACGGGAAAG ATGCCTTCCG AAAGCACTTG GCCCTAAAGA GAAAACACTA GGAGGATGGG 000160
000161 AACCAGGGAC AGAGAAGCTA CTTGCTCTGC AGCTGTTTGG GCCAGTATGT TCCCTAATCT TGATGGCCAT CCTGGGCTTA 000240
000241 TTTTCCTGAG AGTCTCTAAG TGACTCACTG CATCACGTAA AACTAAGAAA AAGGATGTCC TGAATTTTCC TGCTTAGAGA 000320
000321 GCTTGTTTTT CTTTCCTGTT GCATCAAAGG GGTCTGTTAA ACTTTCTAAA AGTACTAATC TGACCTGATA TCTGAAGTAA 000400
000401 CAGATAGGAA TTTGGGCTCT TTAAATGGAG CCCTTCCCCC ATACCTGCAT CTCATTGAAG AGGCTGAACT TCAAAACAAA 000480
000481 ATCATGTTGG AGAATTAAGT CTCGTTCCCA GATTTAATTT CTTATTTTTA TATTGTTGCA TAAGAAATCT ACTCTATAAG 000560
000561 GCATCTATTT TCAAATTTGG AAAATCTTAT TTTAAGTTCA TTTATTTAAA GACCAACAAA CAAAAACACC AAATTCACTA 000640
000641 GCCCAGGTCT TTATG
000081 CCAGAAGTAA CCCCTTCTAA AACGGGAAAG ATGCCTTCCG AAAGCACTTG GCCCTAAAGA GAAAACACTA GGAGGATGGG 000160
000161 AACCAGGGAC AGAGAAGCTA CTTGCTCTGC AGCTGTTTGG GCCAGTATGT TCCCTAATCT TGATGGCCAT CCTGGGCTTA 000240
000241 TTTTCCTGAG AGTCTCTAAG TGACTCACTG CATCACGTAA AACTAAGAAA AAGGATGTCC TGAATTTTCC TGCTTAGAGA 000320
000321 GCTTGTTTTT CTTTCCTGTT GCATCAAAGG GGTCTGTTAA ACTTTCTAAA AGTACTAATC TGACCTGATA TCTGAAGTAA 000400
000401 CAGATAGGAA TTTGGGCTCT TTAAATGGAG CCCTTCCCCC ATACCTGCAT CTCATTGAAG AGGCTGAACT TCAAAACAAA 000480
000481 ATCATGTTGG AGAATTAAGT CTCGTTCCCA GATTTAATTT CTTATTTTTA TATTGTTGCA TAAGAAATCT ACTCTATAAG 000560
000561 GCATCTATTT TCAAATTTGG AAAATCTTAT TTTAAGTTCA TTTATTTAAA GACCAACAAA CAAAAACACC AAATTCACTA 000640
000641 GCCCAGGTCT TTATG
Labs working on this lncRNA
- Key Laboratory of RNA Biology, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China; Beijing Key Laboratory of Noncoding RNA, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China; University of Chinese Academy of Sciences, Beijing 100049, China.
