Difference between revisions of "CERNA1"
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CERNA1 (competing endogenous lncRNA 1 for miR-4707-5p and miR-4767) | CERNA1 (competing endogenous lncRNA 1 for miR-4707-5p and miR-4767) | ||
[[File:LncRNA CERNA1 was upregulated by ABO.jpg|right|thumb|400px|'''LncRNA CERNA1 was upregulated by ABO.'''<ref name="ref1" />]] | [[File:LncRNA CERNA1 was upregulated by ABO.jpg|right|thumb|400px|'''LncRNA CERNA1 was upregulated by ABO.'''<ref name="ref1" />]] | ||
| + | [[File:LncRNA CERNA1 regulated the expression of miR-4707-5p and miR-4767 by directly binding with them..jpg|right|thumb|400px|'''LncRNA CERNA1 regulated the expression of miR-4707-5p and miR-4767 by directly binding with them..'''<ref name="ref1" />]] | ||
===Synonyms=== | ===Synonyms=== | ||
LOC100129973 | LOC100129973 | ||
Revision as of 10:37, 15 October 2017
Contents
Annotated Information
Approved Symbol
CERNA1 (competing endogenous lncRNA 1 for miR-4707-5p and miR-4767)
LncRNA CERNA1 was upregulated by ABO.[1]
File:LncRNA CERNA1 regulated the expression of miR-4707-5p and miR-4767 by directly binding with them..jpg
LncRNA CERNA1 regulated the expression of miR-4707-5p and miR-4767 by directly binding with them..[1]
Synonyms
LOC100129973
Chromosome
15q21.2
RefSeq(supplied by NCBI)
NR_102751
pubmed IDs
26887505
Characteristics
CERNA1 is a 1520bp length validated long noncoding RNA. It locates in chromosome 15 (21.1) and antisense to guanine nucleotide binding protein,beta 5 (GNB5) and myosin VC (MYO5C). [1] CERNA1 is only found in Homo sapiens.[1]
Expression
CERNA1 wis upregulated by ABO (6-amino-2,3-dihydro-3-hydroxymethyl-1,4-benzoxazine) treatment in a dose- and time -dependent manner.
Disease
cardiovascular disease
Function
CERNA1 suppresses apoptosis by targeting miR-4707-5p and miR-4767 in vascular endothelial cells.[1]
Labs working on this lncRNA
- Shandong Provincial Key Laboratory of Animal Cells and Developmental Biology, School of Life Science, Shandong University, Jinan 250100, China.
- Institute of Organic Chemistry, School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, China.
- The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, Shandong University Qilu Hospital, Jinan, 250012, China.
