Difference between revisions of "DSCAM-AS1"

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DSCAM-AS1 (DSCAM antisense RNA 1)
 
DSCAM-AS1 (DSCAM antisense RNA 1)
 
[[File:Characterization of DSCAM-AS1.jpg|right|thumb|400px|'''Characterization of DSCAM-AS1'''<ref name="ref1" />]]
 
[[File:Characterization of DSCAM-AS1.jpg|right|thumb|400px|'''Characterization of DSCAM-AS1'''<ref name="ref1" />]]
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[[File:Physical and functional relationship of DSCAM-AS1 with hnRNPL.jpg|right|thumb|400px|'''Physical and functional relationship of DSCAM-AS1 with hnRNPL'''<ref name="ref1" />]]
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===Synonyms===
 
===Synonyms===
 
M41
 
M41

Revision as of 02:52, 13 November 2017

Annotated Information

Approved Symbol

DSCAM-AS1 (DSCAM antisense RNA 1)

Characterization of DSCAM-AS1[1]
Physical and functional relationship of DSCAM-AS1 with hnRNPL[1]

Synonyms

M41

Chromosome

21q22.2

RefSeq ID

NR_038896

RefSeq(supplied by NCBI)

NR_038896

pubmed IDs

27666543

Disease

breast cancer

Characteristics

ER preferentially binds to the DSCAM-AS1 promoter in tumours with clinical aggression.[1]

Function

DSCAM-AS1 mediates tumour progression and tamoxifen resistance.[1] DSCAM-AS1 provides oestrogen-independent growth and a proliferative advantage when grown in oestrogen-deprived medium compared to normal serum.[1]

Regulation

hnRNPL is an interacting protein involved in the mechanism of DSCAM-AS1 action.[1]

Expression

DSCAM-AS1 expression is highly enriched in ER-positive tumours.[1]

Labs working on this lncRNA

  • Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, Michigan 48109, USA
  • Department of Cellular and Molecular Biology, University of Michigan, Ann Arbor, Michigan 48109, USA.

References