Difference between revisions of "DINOL"

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==Annotated Information==
 
==Annotated Information==
 +
[[File:p53 is a DINO-binding protein.jpg|right|thumb|400px|'''p53 is a DINO-binding protein'''<ref name="ref1" />]]
 +
[[File:Germline disruption of mouse Dino impairs the p53-dependent, DNA damage-induced apoptosis.jpg|right|thumb|400px|'''Germline disruption of mouse Dino impairs the p53-dependent, DNA damage-induced apoptosis'''<ref name="ref1" />]]
 
===Approved Symbol===
 
===Approved Symbol===
 
DINOL (damage induced long noncoding RNA)
 
DINOL (damage induced long noncoding RNA)
 
===Synonyms===
 
===Synonyms===
 
DINO
 
DINO
[[File:p53 is a DINO-binding protein.jpg|right|thumb|400px|'''p53 is a DINO-binding protein'''<ref name="ref1" />]]
 
[[File:Germline disruption of mouse Dino impairs the p53-dependent, DNA damage-induced apoptosis.jpg|right|thumb|400px|'''Germline disruption of mouse Dino impairs the p53-dependent, DNA damage-induced apoptosis'''<ref name="ref1" />]]
 
 
 
===Chromosome===
 
===Chromosome===
 
6p21.2
 
6p21.2
===RefSeq ID===
 
NR_144384
 
 
===RefSeq(supplied by NCBI)===
 
===RefSeq(supplied by NCBI)===
 
NG_009364
 
NG_009364

Revision as of 03:18, 13 November 2017

Annotated Information

p53 is a DINO-binding protein[1]
Germline disruption of mouse Dino impairs the p53-dependent, DNA damage-induced apoptosis[1]

Approved Symbol

DINOL (damage induced long noncoding RNA)

Synonyms

DINO

Chromosome

6p21.2

RefSeq(supplied by NCBI)

NG_009364

pubmed IDs

27668660

Characteristic

DINO is a 951-base RNA transcribed divergently from CDKN1A.[1] DINO occupancies at p53 binding elements in 7 of 10 p53-target genes examined, including CDKN1A, GADD45A, and DDB2.[1]

Function

DINO encodes a p53-dependent DNA damage-induced transcript.[1] DINO stabilizes p53 and enhances regulation of its target genes.[1] Loss of DINO abrogates DNA damage-induced gene regulation and cell cycle arrest.[1]

Labs working on this lncRNA

  • Center for Personal Dynamic Regulomes, Stanford University School of Medicine, Stanford, California, USA.
  • Department of Radiation Oncology, Stanford University School of Medicine, Stanford, California, USA.

References