Difference between revisions of "ELF3-AS1"

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ELF3-AS1:ELF3 antisense RNA 1
 
ELF3-AS1:ELF3 antisense RNA 1
  
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ENST00000415582<ref name="ref1" />
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ENST00000415582 <ref name="ref1" />
 
===Function===
 
===Function===
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Receiver operating characteristic curve(ROC) analyses indicates that the use of ENST00000415582 has high diagnostic sensitivity and specificity for predicting non-131I-avid lung metastases of Papillary Thyroid Cancer(PTC). Low ENST00000415582 lncRNA level is also found to be associated with better prognosis of PTC patients with lung metastases(P<0.001). <ref name="ref1" />
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ELF3-AS1 may be used as novel and minimally invasive markers for the diagnosis and prognostic assessment of non-131I-avid lung metastases from Papillary Thyroid Cancer(PTC) <ref name="ref1" />. ELF3-AS1 has high diagnostic sensitivity and specificity for predicting non-131I-avid lung metastases of PTC, and low ELF3-AS1 lncRNA level is associated with better prognosis of PTC patients with lung metastases (P<0.001) <ref name="ref1" />.
 
===Expression===
 
===Expression===
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[[File:ENST00000415582.JPG|right|thumb|400px|'''expression of ENST00000415582''' <ref name="ref1" />.]]
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[[File:ENST00000415582.JPG|right|thumb|400px|'''Expression of ELF3-AS1 in Papillary Thyroid Cancer patients''' <ref name="ref1" />.]]
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ENST00000415582 is significantly upregulated in samples from the non-131I-avid lung metastasis group (p<0.05).<ref name="ref1" />  
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ELF3-AS1 is significantly upregulated in samples from the non-131I-avid lung metastasis group comparing with 131I-avid lung metastasis group(p<0.05) <ref name="ref1" />.
 
===Diseases===
 
===Diseases===
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Papillary Thyroid Cancer Patients with Lung Metastases.<ref name="ref1" />
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Papillary Thyroid Cancer <ref name="ref1" />
 
===Sequence===
 
===Sequence===
 
>XR_426886.2 PREDICTED: Homo sapiens uncharacterized LOC102723465 (LOC102723465), ncRNA
 
>XR_426886.2 PREDICTED: Homo sapiens uncharacterized LOC102723465 (LOC102723465), ncRNA

Revision as of 07:41, 13 November 2017

Annotated Information

Name

ELF3-AS1:ELF3 antisense RNA 1

ENST00000415582 [1]

Function

ELF3-AS1 may be used as novel and minimally invasive markers for the diagnosis and prognostic assessment of non-131I-avid lung metastases from Papillary Thyroid Cancer(PTC) [1]. ELF3-AS1 has high diagnostic sensitivity and specificity for predicting non-131I-avid lung metastases of PTC, and low ELF3-AS1 lncRNA level is associated with better prognosis of PTC patients with lung metastases (P<0.001) [1].

Expression

Expression of ELF3-AS1 in Papillary Thyroid Cancer patients [1].

ELF3-AS1 is significantly upregulated in samples from the non-131I-avid lung metastasis group comparing with 131I-avid lung metastasis group(p<0.05) [1].

Diseases

Papillary Thyroid Cancer [1]

Sequence

>XR_426886.2 PREDICTED: Homo sapiens uncharacterized LOC102723465 (LOC102723465), ncRNA

000001 AATACTCATG GATTAATTGG TGCTGGCTGG GCCTGCCAGC CTAGTCGTGG CCCCAGGGTC CCCACTAAAG GGCTCCTTCT 000080
000081 CCAGCGCCCA CTCTGTTGGC AAGGTCTTCA CTACCATCAC CTGCCTGGAC TCCATCCAAG CATCAGGGTT GCTGCAGTCG 000160
000161 CTCCTGAAGA GACCCGGCTC TGCTTGAAAG TTCTTCCCTC AGCGCCTGCT GGAGCCCTCC CTGCCGGAGT TGCCAGAATC 000240
000241 CACACGGAAT CCACAGATCT GCCCTGATGA TCATGAAGGA ATGCGAAAGA GCCTGGTAAA ACGATATGGA CTTGTGCAAA 000320
000321 TGCAAAGCAA TGGTGAAGTC ATCACGAACC GCACAGACTG GACAGAACTC CTATCTGGCT GCAATGGCTT GGGTTCAGTC 000400
000401 AGCCCAGGGG CCAGAGAATT GGCTACAAAG AGCTCTGGAG TGCCCCTCCC TCCAAATAAA GTATTCTAAG CGTGCACTGA 000480

Labs working on this lncRNA

  • Department of Nuclear Medicine, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.

References

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Qiu ZL, Shen CT, Sun ZK, Wei WJ, Zhang XY, Song HJ, Luo QY. Circulating Long Non-Coding RNAs Act as Biomarkers for Predicting 131I Uptake and Mortality in Papillary Thyroid Cancer Patients with Lung Metastases. Cell Physiol Biochem. 2016;40(6):1377-1390.
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