Difference between revisions of "LINC00240"

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===Function===
 
===Function===
 
[[File:LINC00240 function.jpg|right|thumb|400px|'''Dysregulation of PVT1 and ''LINC00240'' as ceRNAs in ESCC'''<ref name="ref1" />.]]
 
[[File:LINC00240 function.jpg|right|thumb|400px|'''Dysregulation of PVT1 and ''LINC00240'' as ceRNAs in ESCC'''<ref name="ref1" />.]]
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Enrichment analysis between LINC00240 and neighbor mRNAs shows that LncRNAs of LINC00240 is related to the function of cell cycle and cancer-associated pathways such as “P53 signaling pathway”, “Cell cycle” and “Pathway in cancer” etc. Meanwhile, in the subtype 2 of ESCC(esophageal squamous cell carcinoma), the “loss” of miR-26b-5p-mediated LINC00240-associated crosstalks accompanies the bad prognosis. And the “loss” of miRNA-mediated crosstalks between LINC00240 and LOX gene family might result from LOX-mediated dysregulation of ECM.<ref name="ref1" />
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Enrichment analysis between LINC00240 and neighbor mRNAs shows that LINC00240 is related with the function of cell cycle and cancer-associated pathways such as “P53 signaling pathway”, “Cell cycle” and “Pathway in cancer” etc <ref name="ref1" />. In subtype 2 of ESCC (esophageal squamous cell carcinoma), the “loss” of miR-26b-5p-mediated LINC00240-associated crosstalks accompanies the bad prognosis <ref name="ref1" />
  
 
===Regulation===
 
===Regulation===
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In the subtype 2 of ESCC(esophageal squamous cell carcinoma), most loss of LINC00240-associated crosstalks are possibly mediated by miR-26b-5p.<ref name="ref1" />
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LINC00240 functions as a ceRNA and is targetted by miR-26b-5p <ref name="ref1" />.
 
===Diseases===
 
===Diseases===
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Esophageal squamous cell carcinoma<ref name="ref1" />
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Esophageal squamous cell carcinoma <ref name="ref1" />
 
===Sequence===
 
===Sequence===
 
>NR_026775.2 Homo sapiens long intergenic non-protein coding RNA 240 (LINC00240), long non-coding RNA
 
>NR_026775.2 Homo sapiens long intergenic non-protein coding RNA 240 (LINC00240), long non-coding RNA

Latest revision as of 08:26, 13 November 2017

Annotated Information

Name

LINC00240:long intergenic non-protein coding RNA 240

Function

Dysregulation of PVT1 and LINC00240 as ceRNAs in ESCC[1].

Enrichment analysis between LINC00240 and neighbor mRNAs shows that LINC00240 is related with the function of cell cycle and cancer-associated pathways such as “P53 signaling pathway”, “Cell cycle” and “Pathway in cancer” etc [1]. In subtype 2 of ESCC (esophageal squamous cell carcinoma), the “loss” of miR-26b-5p-mediated LINC00240-associated crosstalks accompanies the bad prognosis [1]

Regulation

LINC00240 functions as a ceRNA and is targetted by miR-26b-5p [1].

Diseases

Esophageal squamous cell carcinoma [1]

Sequence

>NR_026775.2 Homo sapiens long intergenic non-protein coding RNA 240 (LINC00240), long non-coding RNA

000001 GAGGGAGCCC GCTCAGGCCT CAGCCAGCAC AGAGAGGGGC TCCCACGGTG CAGCTGCGGG CTGAAGGGCT CCTGAAGCGC 000080
000081 GGCCAGAGTG GGCTGAGGCC GAGGAGGCGC CGAGAGCCAG CGAGGGGATG CCAGCAAGCT GTCACCTCTC AGAAATACAG 000160
000161 GAAGAACATC AATAATGTTC GAAGTTATAA ATTGCGGAGG CCAGAAGTCA GAAAACAAGG TGTCTGCAGG ACCAACCTCT 000240
000241 CCTCTGGATG CTCTAGGAGA AGCCAGCTCC CATGTTAAGA AGTTCAAATA CCTAGAGACT GCGATGGTTT GCAGAGGCTC 000320
000321 AAGCTAACCA CATGGAAAGA CATGGAGAGA TATTCCTTGC CAACCCTCAA CTACTCCAAC TATTCTAAGA CATCAAACCT 000400
000401 GTGAGTGAAA AAGCCATCTC ATACCTTACA ACTCTAGCAG ATGCCACATA GTGTAGAGAT AAGCTCTCTC TGTCATTCTC 000480
000481 TGTCAAAATT GTAAAATCAT AAGCAAATAA ATAATCACAG TTGCTTCAAG TTACTACATT TGAGCATAGT ATTTTAAGCC 000560
000561 ACTGCATTTG AGATGGTTTG TTATACAGCA ATAGATAACT AAAAAACAAA GTCCCTTGAT TTAGACTTGT CCACTCAACT 000640
000641 TGCTTGGCCA ATGGAATGGG GTAGAAGTGA TGGTGTGCTT ATTCCCAGCC TGGGCCTTAA AAGGCTTTGC CTATTTCCAC 000720
000721 TTGCCTTCTT GTACTTCTGC TATTGTCATA AGAAAAACAA ACCGCAGGTC ACCCACCGGT CTGAAGAGGA GGATGAGAGA 000800
000801 CAAAGAAAAA AGTTGTCTGG CTGCCTCTGC TGTCTACAGA TTGAAGAAGA TCCATCCAGC TGAGCCCAGC CTAGACCAGC 000880
000881 TGACTTCTCC AATAAGCCTG TATGAAATAA ATGCTTATTG TTATGTGACC TTGAGCTTTG AAGATAGTTT GTTATGCAAT 000960
000961 AATTGTTGAT TCTTTCAAAA AAA


Labs working on this lncRNA

  • Department of Bioinformatics and Biostatistics, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China.

References

  1. ↑ 1.0 1.1 1.2 1.3 1.4 Yang S, Ning Q, Zhang G, Sun H, Wang Z, Li Y. Construction of differential mRNA-lncRNA crosstalk networks based on ceRNA hypothesis uncover key roles of lncRNAs implicated in esophageal squamous cell carcinoma. Oncotarget. 2016 Dec 27;7(52):85728-85740.
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