Difference between revisions of "RAD51-AS1"
| Line 2: | Line 2: | ||
===Approved Symbol=== | ===Approved Symbol=== | ||
RAD51-AS1 (RAD51 antisense RNA 1 (head to head)) | RAD51-AS1 (RAD51 antisense RNA 1 (head to head)) | ||
| + | [[File:E2F1 induction oppositely affects endogenous RAD51 and TODRA expression.jpg|right|thumb|400px|'''E2F1 induction oppositely affects endogenous RAD51 and TODRA expression.'''<ref name="ref1" />]] | ||
| + | [[File:TODRA promotes homologous recombination repair of DSBs.jpg|right|thumb|400px|'''TODRA promotes homologous recombination repair of DSBs..'''<ref name="ref1" />]] | ||
===Synonyms=== | ===Synonyms=== | ||
TODRA | TODRA | ||
| − | |||
===Chromosome=== | ===Chromosome=== | ||
15q15.1 | 15q15.1 | ||
Revision as of 12:25, 7 January 2018
Contents
Annotated Information
Approved Symbol
RAD51-AS1 (RAD51 antisense RNA 1 (head to head))
E2F1 induction oppositely affects endogenous RAD51 and TODRA expression.[1]
TODRA promotes homologous recombination repair of DSBs..[1]
Synonyms
TODRA
Chromosome
15q15.1
RefSeq ID
NR_040058
Ensembl ID
ENSG00000245849
pubmed IDs
26230935
Charateristic
TODRA, a lncRNA immediately upstream of RAD51 is transcribed in the opposite direction.[1].
Expression
TODRA is overexpressed in HeLa cells.[1].
Regulation
E2F1 regulates endogenous TODRA transcript levels.[1].
Function
TODRA overexpression in HeLa cells induced expression of TPIP, a member of the TPTE family which includes PTEN.[1]. TODRA lncRNA affects RAD51 dysregulation and RAD51-dependent DSB repair in malignancy.[1]. TODRA promotes homologous recombination repair of DSBs.[1].
Labs working on this lncRNA
- Human Genetics, Hebrew University Medical School, Jerusalem, Israel; Medical Genetics Institute, Shaare Zedek Medical Center, Jerusalem, Israel. [1]
References
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 1: Gazy I, Zeevi DA, Renbaum P, Zeligson S, Eini L, Bashari D, Smith Y, Lahad A, Goldberg M, Ginsberg D, Levy-Lahad E. TODRA, a lncRNA at the RAD51 Locus, Is Oppositely Regulated to RAD51, and Enhances RAD51-Dependent DSB (Double Strand Break) Repair. PLoS One. 2015 Jul 31;10(7):e0134120. doi:10.1371/journal.pone.0134120.
Sequence
>gi|338827631|ref|NR_040058.1| Homo sapiens RAD51 antisense RNA 1 (head to head) (RAD51-AS1), long non-coding RNA
000001 CTTCTCCCCG CTTCCGCCCT GCGCGCTAAC CCAAGACGGG AGCTCGAGAG CTTGATCCTG CGCGAGTTTA CAGACTGCCC 000080
000081 TCTTCCCTTT TTGCATCGAA GACCACGACT CCCAAGAGGT AATGCGTCGG CCCGGGACTA CATCTCCCGG CATGCATCGC 000160
000161 CGGCGGGTCC GCGAGTTCTC ACCATCGCAG CTGGACTATT AGCGGGGGCC CTAGCGCTCT TGTGGTTTGT TTCGGCAGTA 000240
000241 TCTGAATGTC AGCTTTTGGC ACTTCTGGTC GCTCTGAGCC TCCTACTCGC ATTCCTGGAG CAAGGTGCTT TCCAGGCCTC 000320
000321 ATGGAGGTGG AGGAGCTGAG GAAGCTCGAG AAGATGGATA GAAGTGGGAA ATGGAGCTAG CGTACGGGAG AGGGAAATGG 000400
000401 CTGGAATATT CGTCAATCTG TGGTGCTTTA CTGGAGATTT GCAGGAGTTC AGAGGAAGGG GGCATTGAAT TTCATAACCT 000480
000481 AAACCGTATC GTGGTTTACC AGAAAGTTTT GACCCGTGAT TCCGGTTTTA AAGGCTGAGT AGGGCCGGGC GCGGTGGTTC 000560
000561 ACGCCAGTAA TCCCAGCAGT TTAGGAGGCC AAGGCAGGCG GATCACCTGA GGTCAGGGGT TGGAGATAAA CCTGGCCAAC 000640
000641 GTGGTGAAAC CTCGTCTTTA GTAAAAAATA CAAAAATTAG CCAGGTTTTG TGGCACATGC CTGTAATCCT AGCTACTCGA 000720
000721 AAGGCTGAGG CATGAGAATC GCTTGAACTC AGGAGGAGGT TGCAGCCAAC CGAGATCTCG CCGCTGTACT CCAGCCTGGG 000800
000801 CGACAGAGCG AGACTGTGTC AAAACAACAC CACAAGCTAG CTGAGTAGGG ATTCTTGGGC GAAGTGGAAG ACATTATAAG 000880
000881 CAAATAGGGT AGTATGGGCA TGGAAACGAA CTACATGATT AAAGATTAGT ATTATCTGGC GAGGGAGGAA AAGTGCCAGA 000960
000961 GCAAGTGCCG AAACTGGAAG GTTACATTTA GTTCAGGATA TGAAGATCAT ATAAGGCCTG CACGGTGGCT CACACCTGTA 001040
001041 ATCCCAGCAC TTTGGGAAGC CAAGGTGGGG GAGGATCGCT TGAGCTCAGG AGTTGGAGAC CAGCCTGGGC AACATAGTGG 001120
001121 GACCCCATAT CTCAAAAAAA AAAAAAAAAA AAATAA
000081 TCTTCCCTTT TTGCATCGAA GACCACGACT CCCAAGAGGT AATGCGTCGG CCCGGGACTA CATCTCCCGG CATGCATCGC 000160
000161 CGGCGGGTCC GCGAGTTCTC ACCATCGCAG CTGGACTATT AGCGGGGGCC CTAGCGCTCT TGTGGTTTGT TTCGGCAGTA 000240
000241 TCTGAATGTC AGCTTTTGGC ACTTCTGGTC GCTCTGAGCC TCCTACTCGC ATTCCTGGAG CAAGGTGCTT TCCAGGCCTC 000320
000321 ATGGAGGTGG AGGAGCTGAG GAAGCTCGAG AAGATGGATA GAAGTGGGAA ATGGAGCTAG CGTACGGGAG AGGGAAATGG 000400
000401 CTGGAATATT CGTCAATCTG TGGTGCTTTA CTGGAGATTT GCAGGAGTTC AGAGGAAGGG GGCATTGAAT TTCATAACCT 000480
000481 AAACCGTATC GTGGTTTACC AGAAAGTTTT GACCCGTGAT TCCGGTTTTA AAGGCTGAGT AGGGCCGGGC GCGGTGGTTC 000560
000561 ACGCCAGTAA TCCCAGCAGT TTAGGAGGCC AAGGCAGGCG GATCACCTGA GGTCAGGGGT TGGAGATAAA CCTGGCCAAC 000640
000641 GTGGTGAAAC CTCGTCTTTA GTAAAAAATA CAAAAATTAG CCAGGTTTTG TGGCACATGC CTGTAATCCT AGCTACTCGA 000720
000721 AAGGCTGAGG CATGAGAATC GCTTGAACTC AGGAGGAGGT TGCAGCCAAC CGAGATCTCG CCGCTGTACT CCAGCCTGGG 000800
000801 CGACAGAGCG AGACTGTGTC AAAACAACAC CACAAGCTAG CTGAGTAGGG ATTCTTGGGC GAAGTGGAAG ACATTATAAG 000880
000881 CAAATAGGGT AGTATGGGCA TGGAAACGAA CTACATGATT AAAGATTAGT ATTATCTGGC GAGGGAGGAA AAGTGCCAGA 000960
000961 GCAAGTGCCG AAACTGGAAG GTTACATTTA GTTCAGGATA TGAAGATCAT ATAAGGCCTG CACGGTGGCT CACACCTGTA 001040
001041 ATCCCAGCAC TTTGGGAAGC CAAGGTGGGG GAGGATCGCT TGAGCTCAGG AGTTGGAGAC CAGCCTGGGC AACATAGTGG 001120
001121 GACCCCATAT CTCAAAAAAA AAAAAAAAAA AAATAA
