Difference between revisions of "PARTICL"
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===Approved Symbol=== | ===Approved Symbol=== | ||
PARTICL (promoter of MAT2A antisense radiation-induced circulating long non-coding RNA) | PARTICL (promoter of MAT2A antisense radiation-induced circulating long non-coding RNA) | ||
| − | [[File:PARTICLE Knockdown through Stable Lentiviral Transfection Causes MAT2A Overexpression and Promoter Over-activity.png|right|thumb|400px|''' | + | [[File:PARTICLE Knockdown through Stable Lentiviral Transfection Causes MAT2A Overexpression and Promoter Over-activity.png|right|thumb|400px|'''PARTICL Knockdown through Stable Lentiviral Transfection Causes MAT2A Overexpression and Promoter Over-activity'''<ref name="ref1" />]] |
| − | [[File: PARTICLE Knockdown Enhances Expression of the Catalytic Subunit of MAT and Increases Intracellular and Extracellular SAM Availability.png|right|thumb|400px|''' | + | [[File: PARTICLE Knockdown Enhances Expression of the Catalytic Subunit of MAT and Increases Intracellular and Extracellular SAM Availability.png|right|thumb|400px|''' PARTICL Knockdown Enhances Expression of the Catalytic Subunit of MAT and Increases Intracellular and Extracellular SAM Availability'''<ref name="ref1" />]] |
===Synonyms=== | ===Synonyms=== | ||
PARTICLE | PARTICLE | ||
Revision as of 14:29, 13 January 2018
Contents
Annotated Information
Approved Symbol
PARTICL (promoter of MAT2A antisense radiation-induced circulating long non-coding RNA)
PARTICL Knockdown through Stable Lentiviral Transfection Causes MAT2A Overexpression and Promoter Over-activity[1]
PARTICL Knockdown Enhances Expression of the Catalytic Subunit of MAT and Increases Intracellular and Extracellular SAM Availability[1]
Synonyms
PARTICLE
Chromosome
2p11.2
RefSeq ID
NR_038942
OMIM ID
616350
Characteristics
PARTICL, a promoter of MAT2A-antisense radiation-induced circulating lncRNA and it forms a DNA-lncRNA triplex upstream of a MAT2A promoter CpG island.[1]
Function
PARTICL is a suppressor of MAT2A through triple helix formation and provides a methyltransferase and polycomb repressor complex recruitment platform.[1] Knockdown of PARTICL with lentivirus encoding shRNA_B resulted in an overshoot of MAT2A expression (7.7-fold increase, p = 0.0038) following low-dose (0.25 Gy) irradiation in MDA-MB-361 cells.[1] PARTICL knockdown and irradiation have an additive effect on intracellular and extracellular sam production. [1]
Expression
Exposure to low-dose irradiation causes transiently elevated expression of the long ncRNA PARTICL. [1]
Labs working on this lncRNA
- Institute of Radiation Biology, Helmholtz Zentrum Munich, German Research Center for Environmental Health, Ingolstaedter Landstrasse 1, 85764 Neuherberg, Germany. [1]
References
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 O'Leary VB, Ovsepian SV, Carrascosa LG, Buske FA, Radulovic V, Niyazi M, Moertl S, Trau M, Atkinson MJ, Anastasov N. PARTICLE, a Triplex-Forming Long ncRNA, Regulates Locus-Specific Methylation in Response to Low-Dose Irradiation. Cell Rep. 2015 Apr 21;11(3):474-85. PubMed PMID: 25900080.
Sequence
>gi|336595103|ref|NR_038942.1| Homo sapiens promoter of MAT2A antisense radiation-induced circulating long non-coding RNA (PARTICL), long non-coding RNA
000001 TGTGGGAGAA AAAGCGACTG GGGCTTGCTG GACCCGCTCC CCTGTGCGGT GACATGGCAC CTCCCTTCCG ACCGTTGGCC 000080
000081 GGGATAGCTT TCCCGGAGGT CGCGTCCCCC AGCGGAGGCG GCGGGAATCG CGGAGGTTTT GTGCTGCGGC TGGGGTCTTT 000160
000161 CTGGCCGTCC CGCCTCTAGA TGCCGGGTGG CAGGGAGCCG GTGGCGGTCG GCCATGTGAA GGTGGCCATC TTGGCCGGCC 000240
000241 AGCGAGGGCT CCTCACGGCC TTCCTTCGGC GTCCCTGCCC GGCTCGTTGC CGGCCCCGGG ATATCTGAGG GGCGCAGGCC 000320
000321 CACCTTCTAG TCGTTTCCTG GTGAATGGCT CTGCTGAAGA TGGCCGGAAA GCAGATTAAT GAAGGTGCTG CCATCGATTT 000400
000401 AAACAATCGC CCTCCTGCCC GCTCCCCTGC GCTAAAGTTT CTGAGGGATC CTCACCCTTC GTGGTTCGTG GACTTAAAAG 000480
000481 TGGAGGCAGC GCTCCAGCCT TTCCCTCCAG AGAGAAAGGA GGCCGCTCCC AAGTCCGTCC TTGCCCCGTG GCCTTCCTGT 000560
000561 TCCTTTGAAG GGGGGGGGAA TCGATGTTTC AATCCTCTGT TCAGGAGAAT ATGGAACGAA CATTTCTTTT TTGGTGGGTG 000640
000641 GGGGCTATTC GTTCCCTTGA ATGTGCTTAA GCAGATCTCT TGACGGCGTG GAATGGGCTG TTTCATGAAG CTTTCACTTT 000720
000721 AAAATGTCCA CCTGCGTTTG TCCCAGTTTT GCCCAATAAA GGAATTACAG GGAAAAAGAG CGAAACAAAA CTTGAGCCAG 000800
000801 CAAGGAGTAT GGAGTCCCGT TTGGAGGGAG CCCGCCTTGG GGGCGGGGGT CTCTGCAGCC TGTTCTGGGG CTGGGCCTCG 000880
000881 GTGCAGGTCT GGTCGGGCTG GTGGCCTGGT GGCCCTGAGC GGAGCGCGTG ACAAGAACGC CGGGTTTAAT GAGGTTCTCA 000960
000961 GGGAACGGCC TGCTCCTAGC ATGGGATGTA CTTTACGCTG GGGAGGTGAA GGAGACCCCT AGTAACAGTC TCCAGCTGCC 001040
001041 TACTGCTGGC GGCAGTAGAA CAAGGTGCAT TCCCAAGAAC AATCCTCTCC GTCGGTGCAG GAGGAAAGGT GGGATTTGCT 001120
001121 AAAGGCTCAG TGGGAAACAA AGGAAGCACT TGGGCTGTGC TGGGGGCATC CACAAAGAAG ATAAAGGGCT CCTCCCCAGA 001200
001201 CTCAGTGACC ACATCCACGG TCGCTCAAAG CAGGCAGCAA GAAAAGGTTC GACCACAAAA GAGACAATAG GTGATGATAT 001280
001281 TTTTATTCGT TGCTTTTTAC TTTTCAAGCT AACCCTTCAT GGGAAAGTAA CTGTATAAGA CTATTAAATT TTTTTGTTAT 001360
001361 TTTTTAAAGG AGAATGCCAA TTTATTAACT TACAATGTGT AATAAAATTG TCAACTGGAA AAAAAAAAAA AA
000081 GGGATAGCTT TCCCGGAGGT CGCGTCCCCC AGCGGAGGCG GCGGGAATCG CGGAGGTTTT GTGCTGCGGC TGGGGTCTTT 000160
000161 CTGGCCGTCC CGCCTCTAGA TGCCGGGTGG CAGGGAGCCG GTGGCGGTCG GCCATGTGAA GGTGGCCATC TTGGCCGGCC 000240
000241 AGCGAGGGCT CCTCACGGCC TTCCTTCGGC GTCCCTGCCC GGCTCGTTGC CGGCCCCGGG ATATCTGAGG GGCGCAGGCC 000320
000321 CACCTTCTAG TCGTTTCCTG GTGAATGGCT CTGCTGAAGA TGGCCGGAAA GCAGATTAAT GAAGGTGCTG CCATCGATTT 000400
000401 AAACAATCGC CCTCCTGCCC GCTCCCCTGC GCTAAAGTTT CTGAGGGATC CTCACCCTTC GTGGTTCGTG GACTTAAAAG 000480
000481 TGGAGGCAGC GCTCCAGCCT TTCCCTCCAG AGAGAAAGGA GGCCGCTCCC AAGTCCGTCC TTGCCCCGTG GCCTTCCTGT 000560
000561 TCCTTTGAAG GGGGGGGGAA TCGATGTTTC AATCCTCTGT TCAGGAGAAT ATGGAACGAA CATTTCTTTT TTGGTGGGTG 000640
000641 GGGGCTATTC GTTCCCTTGA ATGTGCTTAA GCAGATCTCT TGACGGCGTG GAATGGGCTG TTTCATGAAG CTTTCACTTT 000720
000721 AAAATGTCCA CCTGCGTTTG TCCCAGTTTT GCCCAATAAA GGAATTACAG GGAAAAAGAG CGAAACAAAA CTTGAGCCAG 000800
000801 CAAGGAGTAT GGAGTCCCGT TTGGAGGGAG CCCGCCTTGG GGGCGGGGGT CTCTGCAGCC TGTTCTGGGG CTGGGCCTCG 000880
000881 GTGCAGGTCT GGTCGGGCTG GTGGCCTGGT GGCCCTGAGC GGAGCGCGTG ACAAGAACGC CGGGTTTAAT GAGGTTCTCA 000960
000961 GGGAACGGCC TGCTCCTAGC ATGGGATGTA CTTTACGCTG GGGAGGTGAA GGAGACCCCT AGTAACAGTC TCCAGCTGCC 001040
001041 TACTGCTGGC GGCAGTAGAA CAAGGTGCAT TCCCAAGAAC AATCCTCTCC GTCGGTGCAG GAGGAAAGGT GGGATTTGCT 001120
001121 AAAGGCTCAG TGGGAAACAA AGGAAGCACT TGGGCTGTGC TGGGGGCATC CACAAAGAAG ATAAAGGGCT CCTCCCCAGA 001200
001201 CTCAGTGACC ACATCCACGG TCGCTCAAAG CAGGCAGCAA GAAAAGGTTC GACCACAAAA GAGACAATAG GTGATGATAT 001280
001281 TTTTATTCGT TGCTTTTTAC TTTTCAAGCT AACCCTTCAT GGGAAAGTAA CTGTATAAGA CTATTAAATT TTTTTGTTAT 001360
001361 TTTTTAAAGG AGAATGCCAA TTTATTAACT TACAATGTGT AATAAAATTG TCAACTGGAA AAAAAAAAAA AA
