Difference between revisions of "LINC02599"
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===Characteristics=== | ===Characteristics=== | ||
| − | + | [[File: LINC02599_characteristic.jpg|right|thumb|400px|'''Confocal RNA-FISH images showing subcellular localization of UCA1 and AC026904.1 in MCF7 cells underwent EMT.''' <ref name="ref1" />.]] | |
''LINC02599'' is a lncRNA gene with a little or no protein coding potential located at chromosomal location 8q11.21. RNA-FISH data showed that AC026904.1 was highly enriched in the nucleus. It could used as novel biomarkers and therapeutic targets for metastatic breast cancer. <ref name="ref1" /> | ''LINC02599'' is a lncRNA gene with a little or no protein coding potential located at chromosomal location 8q11.21. RNA-FISH data showed that AC026904.1 was highly enriched in the nucleus. It could used as novel biomarkers and therapeutic targets for metastatic breast cancer. <ref name="ref1" /> | ||
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===Function=== | ===Function=== | ||
This lncRNA functions as an enhancer RNA (eRNA) to activate Slug expression at both transcriptional and post-transcriptional levels in cis in breast cancer. Because AC026904.1 is a lncRNA highly enriched in the nucleus it may act to regulate its neighboring genes. <ref name="ref1" /> | This lncRNA functions as an enhancer RNA (eRNA) to activate Slug expression at both transcriptional and post-transcriptional levels in cis in breast cancer. Because AC026904.1 is a lncRNA highly enriched in the nucleus it may act to regulate its neighboring genes. <ref name="ref1" /> | ||
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===Regulation=== | ===Regulation=== | ||
''LINC02599'' is regulated by TGF-β. It is upregulated through TGF-β/Smad pathway in breast cancer. <ref name="ref1" /> | ''LINC02599'' is regulated by TGF-β. It is upregulated through TGF-β/Smad pathway in breast cancer. <ref name="ref1" /> | ||
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===Expression=== | ===Expression=== | ||
''LINC02599'' is highly expressed in metastatic breast cancer and closely associated with poor prognosis.<ref name="ref1" /> | ''LINC02599'' is highly expressed in metastatic breast cancer and closely associated with poor prognosis.<ref name="ref1" /> | ||
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===Disease=== | ===Disease=== | ||
Breast cancer <ref name="ref1" /> | Breast cancer <ref name="ref1" /> | ||
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==Labs working on this lncRNA== | ==Labs working on this lncRNA== | ||
Revision as of 06:34, 17 December 2018
LINC02599, long intergenic non-protein coding RNA 2599 with a critical role in TGF-β-induced EMT.
Contents
Annotated Information
Name
LINC02599: long intergenic non-protein coding RNA 2599 (HGNC:53931)
Alias
AC026904.1
Characteristics
LINC02599 is a lncRNA gene with a little or no protein coding potential located at chromosomal location 8q11.21. RNA-FISH data showed that AC026904.1 was highly enriched in the nucleus. It could used as novel biomarkers and therapeutic targets for metastatic breast cancer. [1]
Function
This lncRNA functions as an enhancer RNA (eRNA) to activate Slug expression at both transcriptional and post-transcriptional levels in cis in breast cancer. Because AC026904.1 is a lncRNA highly enriched in the nucleus it may act to regulate its neighboring genes. [1]
Regulation
LINC02599 is regulated by TGF-β. It is upregulated through TGF-β/Smad pathway in breast cancer. [1]
Expression
LINC02599 is highly expressed in metastatic breast cancer and closely associated with poor prognosis.[1]
Disease
Breast cancer [1]
Labs working on this lncRNA
- State Key Laboratory of Cancer Biology, Department of Biochemistry and Molecular Biology, Fourth Military Medical University, Xi'an, China
- Department of Immunology, Fourth Military Medical University, Xi'an, China
- Department of Thoracic Surgery, Tangdu Hospital, Fourth Military Medical University, Xi'an, China
- Department of Oncology, No. 88 Hospital of PLA, Tai'an, China
- Department of Obstetrics and Gynecology, Xijing Hospital, Fourth Military Medical University, Xi'an, China
