Difference between revisions of "LINC00554"
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===Characteristics=== | ===Characteristics=== | ||
| − | ''LINC00554'' has a chromosomal location of 13q32.3 (HGNC | + | ''LINC00554'' has a chromosomal location of 13q32.3 (HGNC data). |
===Function=== | ===Function=== | ||
Revision as of 05:45, 26 December 2018
LINC00554 is involved in a significant signal cascade which can be targetted for eliminating liver tumor-initiating cells (TICs). It is involved in self-renewal of TICs through protein kinase C substrates MARCKS and MARCKSL1 [1].
Contents
Annotated Information
Name
LINC00554: long intergenic non-protein coding RNA 554(HGNC nomenclature). LINC00554 is located near from ZIC2 locus.
Alias
lncZic2 [1]
Characteristics
LINC00554 has a chromosomal location of 13q32.3 (HGNC data).
Function
LINC00554 is required for the self-renewal of liver TICs in a ZIC2-independent manner. LINC00554 drives the expression of myristoylated alanine-rich protein kinase C substrate (MARCKS) and MARCKS-like 1 (MARCKSL1), whose expression levels are increased during liver tumorigenesis and liver TIC self-renewal. Mechanistically, LINC00554 interacts with BRM/SWI2-related gene 1 (BRG1) and recruits this transcriptional regulator to the promoters of the MARCKS and MARCKSL1 gene, which activates expression of these genes. Moreover, the depletion of LINC00554 and BRG1 decreases MARCKS and MARCKSL1 expression and diminishes liver TIC levels [1]. Findings suggest that the LINC00554-BRG1-MARCKS/MARCKSL1 signaling cascade might be a potential target for eliminating liver TICs in the management of liver cancer [1].
Regulation
NA
Diseases
- Liver cancer [1]
Expression
LINC00554 and ZIC2 are both highly expressed in liver TIC, but LINC00554 doesn’t regulate ZIC2 expression [1].
| Experiment | Forward primer | Reverse primer |
|---|---|---|
| NA | NA | NA |
Labs working on this lncRNA
- School of Life Sciences, Zhengzhou University, Zhengzhou 450001, China. [1]
- Department of Pharmaceutical Engineering, School of Chemistry, Wuhan University of Technology, Wuhan 430070, China. [1]
- School of Life Sciences, Zhengzhou University, Zhengzhou 450001, China. [1]
- School of Life Sciences, Zhengzhou University, Zhengzhou 450001, China. [1]
References
Sequence
>gi|100861542|ref|NR_047483.1| Homo sapiens long intergenic non-protein coding RNA 554 (LINC00554), long non-coding RNA
000081 GGCCTGGGCC GCAGCCGTGG GAAGCCGACG ATGCCTGAGG CGCTCTGTCC TCGGCCCACC CTAGGAACTT GTATGACCGC 000160
000161 AGGAAAGGAT CAGGAGAGGC CGCTGCCCGT CTCCCACCGG CTCTAGGCTC CCTCGGCCGA CCGATGTGGG GAAGGGGAAG 000240
000241 GGGCCCGCGC CGAGGCTCTA GGGGAGGCTC CTAGGCCGGG TTCTCTGACT TAAGGCCCTC TTGGCTGTGG TTTTGCGGGA 000320
000321 GTGAGTTGAG GGAGCTGCAT TCACTCAAGT CCCTCACATG CCCGAGGGCC CGGGAATCGT GAAGCCGGGC CTGCGGACCC 000400
000401 GGTGGGAGGA AGGAGTGCGA AGCGCGGCCG CCGTGCTCGG CCGGCGCCGG GCTAGGTCGG GCGGTGGGGA CCGCGCCGGC 000480
000481 ATAGGACAAC GCGGTGGAGG GAAGCACCTG CCCCCGCCCA CCTTGACTCA GGGCCGCCGC GCCCCTCCTG GGCCATCCGC 000560
000561 GCGGGGGTCT CAGGATGGCG AAACCCGGGA CCTCGCGGCC CTCTAGTGCT CCCCTGCCAG GGTGCGACCT AGGTACCCTT 000640
000641 TATCGAGCCC CACTCCCCAA GGCAGAGAGA GTTCGACGTT CCCAAGGAGG GAGTCTCCAT GGAGGAATTC GTCCTGCTTC 000720
000721 ACTTCCAGAG TTGAAAGCCC GTCGGTTCTG CAAAGAGGAG CAGTCGGGCG CGGGCTAGCA AGCAGCTGAT GAAAATAATT 000800
000801 GTCCTCGCAC ACACAGCCCT GCGCCCAGGG GCGCGCGCGC GCACACACAC ACACACACAC ACACACACAC ACACACACAC 000880
000881 AACTTGCCTC CTCTAGCCGC CCAACCTTAA TATTCCGGGC ATGCAGTTTT CAACAACTTG CCTGACACAA TAACAAAGAC 000960
000961 ATTTAAATGC CAGGACGCAG ACTTCACTTT TTAACCTGCT GAGAGGAGCT ACTTTCAAAG CTTCCCCACC GCGAATAAAC 001040
001041 TGACAAAAAA TATGGGGTGC ACTTATAAAT TAAACACCTT ACCCTCAAAG CAATATACGT TAATCAGGTT TCTAAGGCAA 001120
001121 TAGCCATCTC TGTCTTTTCC TATTCACCCA AATAATGCCC CCAGAAGGAA CCCCTTTACA CAAGAGAGAA CTGGAAAAAA 001200
001201 AATGAATTAT ACCCATTGCT AGTAAAAAAT CATCTTAAAT CAATAGAGCA CCACTTGAAC TTGAGTTTCT ATTGTTTCAC 001280
001281 TGAATCATCA ATGTTTTTAA TTAAACAGAG CTACCCTTTC TGTTAAAACA TTACATAAAA GGGTTAGGTT TCTACTTTTG 001360
001361 TTGAGGCAGC TGGCGTTTGT TGGCTGTTGT GTTTGAGCAA CAGACTGTTC AATGGAAGCG AGAAATAGCT CAACGCGCTC 001440
001441 TTAATAGACC TGTTTCAACA ATGTATCTTG AAAAGGAATA CATTGTGTTA TTGTGTTAGT TTGCTACAAA CCTATTAAAA 001520
001521 GAAAAATAGC ATCCATCAGG TCTAACAAGA CGCATTTGTA TTATACGTAC TTATCTGCTT CAAATACACT TCTTGGCACA 001600
001601 ATGTCTAGAA TTCAACTAGA TCATCAGGAG CTGGGCAGAA GAACGCATAC CAGTTAGGTA ATGATACACG GGCTAAAAAT 001680
001681 AATAATAAAG GAAGGACTAA GCAGACGGTA ATTGCTACTT TTTTGTGTAT CATGAGAAAT AACAGGCAAC CCTACTTCAA 001760
001761 TTAAAAATAT ATTGCAAAAG TGTGGACTCC TACGACAAAA ACAATTTAAA AAATATTTGT AGCATGGGAA TATTGATCCA 001840
001841 TATCCCATAT TTGGAACGAA TCTGATACAC TTTCGATAGG AATTTGTTTC AGAGAAGGAT TCAGGGCAGA AGCGATGCAT 001920
001921 TTTTAAAGCA GAATTAAAAC AGCGCAAAGA GCCCGGCTCT TTAGGGAAAT GCGCGAAACA AACAAATCGA AAGCAAGCGT 002000
002001 TCCAGCCAAG TGGTTGGGGA GCACCGTTGT CTGGCACTAG GAAAGGAAGT GCTTCTTGAA AGTGTTCTCT TAAAAATGAT 002080
002081 TTTCCAGACT TATTTTATTG CATTTTAATC ACAAAGTGAA ACTTAAAGCA AAGAAACAGG ACATTCCCGC TACCGAACAG 002160
002161 AACCTATCGT CTATTGCAGG AATGACTGCT ACTTGGACCA CAGACCTTTA GAAAAAACAG AGAGGCAAAT GATTAGGCTA 002240
002241 ATTTAACGCG GAGATCTGCT TAGCAGAAAA GACACCCAAA GTAGCATCTG TCAGAGGAAA ACATCTTTTG CTTCCACACA 002320
002321 AGGCACTCGA TTTGGTTTCC AACCTTGAGT CCTCAACATT CAACTTTCAA GTGCAACAAT GTTGGAGGCA CAAGAGAATA 002400
002401 GTAGATTACC TACAAGTGAA CACAATTGTA CGGAAAAGAG ACTTACATAA GTTACAATGG CACCCTATGT GAGATATCTA 002480
002481 CTTTAACAAA TATGTAGAGC AATATTTTGC CCAATAAAGT CAATCATTTG TTACATTTTT GAATAAGTAA ATTATCACAT 002560
002561 GAAGATTTAG AAAAATGTTA CCCTGAAACA TTAAACGATA GTTTTGCCAT ATTACAAAAT AGCTATTTTA AACTTTTGTA 002640
002641 TAAGGCATTT GAAGCCAAAT GGCTGATATG ACTGTTCTCT TCAGCTGGAA CATTTTTTTT CTTCTCAAGA AGGGTGTGTG 002720
002721 TGAATGATGT GTGTGCATAC TGGAGGTAGT TGAGAAGAAT TTGATTAATA CATAAGACTT TTCACTAATG TCTCCCCTCT 002800
002801 AATCCAAATT TACTTTTTAA ATTAATTCAC TTGGATTTAA AAACAGAAAT GAGATAATAA ACCACAAATT ACACATTATA 002880
002881 AAAATTAGTT TCTCCAATGT ATATGATTTT TGGAAGAGTG CATTTTCAAG GTGAGAATTT TTGATGTGTC TGATAATCTG 002960
002961 CCAGATATGA GAGGAATGTC ACAATAAAAT TGGTTTTGCC ATGATATGAA A
