Difference between revisions of "LINC00707"
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===Name=== | ===Name=== | ||
''LINC00707'': long intergenic non-protein coding RNA 707 <ref name="ref1" />. | ''LINC00707'': long intergenic non-protein coding RNA 707 <ref name="ref1" />. | ||
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===Characteristics=== | ===Characteristics=== | ||
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===Function=== | ===Function=== | ||
| − | [[File:LINC00707.jpg|right|thumb|400px|'''''LINC00707'' knockdown inhibits tumorigenesis of LAD cells in vivo.''' <ref name="ref1" />]] | + | [[File:LINC00707.jpg|right|thumb|400px|'''''LINC00707'' knockdown inhibits tumorigenesis of LAD cells in vivo.'''(A and B) Empty vector or sh-LINC00707 was transfected into A549 cells, which were injected in the BALB/c-nude mice (n=7), respectively. Tumors before and after carrying from the nude mice. (C)Tumor volumes were calculated after injection every five days. Points, mean (n = 6); bars indicate SD.(D) Tumor weights were represented as means of tumor weights ± SD. (E) QRT-PCR was used to detect the average expression of LINC00707 in xenograft tumors (n=7). (F) The tumor sections were under H&E staining and IHC staining using antibodies against ki-67. *P<0.05, **P<0.01. <ref name="ref1" />]] |
''LINC00707'' upregulation was correlated with advanced malignant clinical characteristics. <ref name="ref1" /> | ''LINC00707'' upregulation was correlated with advanced malignant clinical characteristics. <ref name="ref1" /> | ||
Capacity of ''LINC00707'' to promote lung adenocarcinoma (LAD) cell proliferation and migration is achieved partially through the interaction with Cdc42 expression <ref name="ref1" />. | Capacity of ''LINC00707'' to promote lung adenocarcinoma (LAD) cell proliferation and migration is achieved partially through the interaction with Cdc42 expression <ref name="ref1" />. | ||
Latest revision as of 07:53, 26 December 2018
LINC00707 is a noncoding oncogene that exerts important regulatory functions in lung adenocarcinoma (LAD).
Contents
Annotated Information
Name
LINC00707: long intergenic non-protein coding RNA 707 [1].
Characteristics
LINC00707 is 3087 bp long non-coding RNA, located on human chromosome chr10p14, consisting five exons (GenBank) [1]. LINC00707 is mainly located in the cytoplasm [1].
Function
LINC00707 knockdown inhibits tumorigenesis of LAD cells in vivo.(A and B) Empty vector or sh-LINC00707 was transfected into A549 cells, which were injected in the BALB/c-nude mice (n=7), respectively. Tumors before and after carrying from the nude mice. (C)Tumor volumes were calculated after injection every five days. Points, mean (n = 6); bars indicate SD.(D) Tumor weights were represented as means of tumor weights ± SD. (E) QRT-PCR was used to detect the average expression of LINC00707 in xenograft tumors (n=7). (F) The tumor sections were under H&E staining and IHC staining using antibodies against ki-67. *P<0.05, **P<0.01. [1]
LINC00707 upregulation was correlated with advanced malignant clinical characteristics. [1] Capacity of LINC00707 to promote lung adenocarcinoma (LAD) cell proliferation and migration is achieved partially through the interaction with Cdc42 expression [1].
LINC00707 regulate the downstream gene cdc42. Downregulation of Cdc42 inhibits LAD cells proliferation and is involved in the oncogene function of LINC00707. [1].
Expression
LINC00707 was significantly upregulated in lung adenocarcinoma (LAD) compared to that in adjacent normal tissues [1].
Regulation
Please input information here.
Diseases
- Lung adenocarcinoma (LAD) [1]
Labs working on this lncRNA
- Department of Pathology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China. [1]
- Department of Pathology, Zhenjiang First people’s hospital, Zhenjiang, China.[1]
- Department of Anatomy, Histology and Embryology, Nanjing Medical University, Nanjing, China.[1]
- Department of Oncology, Xuzhou Central Hospital, Affiliated Xuzhou Hospital, College of Medicine, Southeast University, Xuzhou, China.[1]
- Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.[1]
References
- ↑ 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 1.11 1.12 1.13 Ma TS, Ma HW, Zou ZG, He XZ, Liu YH, Shuai Y et al. The Long Intergenic Noncoding RNA 00707 Promotes Lung Adenocarcinoma Cell Proliferation and Migration by Regulating Cdc42[J]. Cellular Physiology and Biochemistry. 2018, 45(4):1566-1580.
Sequence
>gi|100507127|ref|NR_038291.1| Homo sapiens long intergenic non-protein coding RNA 707 (LINC00707), long non-coding RNA
000001 AAAATAAAGC AGGCAGAGGA ACGTGGAAGG ACTAGACTGC CTGAGTCTTC TGACCTTCAT CTTTCCCCTG TGTTGGATGC 000080
000081 CTCCTGCCCT CAAACATCAG ACTCCAGGTT CTTCAGCTTT TGGACTCTTG GACCTACCCC CCGAGTGGTT TGCCAGGGGC 000160
000161 TCTCAGGCCT TCGGCTACAG ACTGAGGGCT GCATTATCAG CTTTCCTACT TTTGAGGTTT TGGGACTTTA CTGGCTTTCT 000240
000241 TGCTCCTCAA CTTGCAGATG GCCTGTTGTG GGACCTCACC TTGTGATCAT GTACATGAGG GAAATACACA CCCCTCCCAG 000320
000321 GGATGATGGA AGGTTAAGGT CCTAACACCT CCTGCACATC TGAGCAGCTG CACATTGAAC CAGATAGTCC TGGAATGTGG 000400
000401 GAAAACAGAG GCAGACTCAA GAGTCTGGAA CATTATTTTA GGATCACACA AAAAAGATAC ATAATTTTCA TAGAATGATA 000480
000481 CTGAAAGCAT CTCAAAAATA AAATCACGAG TATCTGCAGA TCACTATGAG ACTGGACTGG AACATTACCT TCAGACACAT 000560
000561 TGATATGACT ACATGCTGGA CATTTTCTTG CGGAAATCCA AAAGAAATCC CCATTTTCTT GCAGAAATCT AAAATAATCT 000640
000641 CCCCTATGTG CAAGTCAGAC TGAGCACCAC TCCCAAGACC ATGACCTCCC CTGCAGCCCT GCTCCTTCCC ACTCACCTCT 000720
000721 CCTCTTGAGA AAGCCACCTC CCACCACCCA GTCTGCAGTG CCAGAAAACT GGAAACCAGC CCCTAAGCTG CTTTCACCTT 000800
000801 CGGCCCATTT CTCACTAGCC AGCCTCTCCC ACGGCCTCCC CAGTTTCTTC AAATACACCC CCTCCACTAT TCACCATACT 000880
000881 GCCACCGTGA TTTATTTACA ACTTTTTGTC CGGATTACCT CAGTAGCCTT CTAATTGTCC CCTTTGCATC TAAAGTAGCC 000960
000961 CCTCTCATCC CCCAAATCTT ACGTCACTCT TCTACATAAT TCTGGCTTTC CATGACCCAT AAACCACATT TCTCAAGTGT 001040
001041 GCTCTATGCT GGCTTGAATA TGTTAATAAT CTTAATTCTA CTTTTAGTGC AATTTTCTTA GAGCTGGCAT CACTTTCATC 001120
001121 ATGACGTGAG AACTTACTAG AGATAGGCAA TGATGACTCA CAGTCAAGCC ACATGTCATA TGCTGCAGAC ATCTGGACTG 001200
001201 CTGCTTATTT GCAAATCCTT TTCTTCATAT TTTTCTCATT TGTAGCACTG GATCAATTCC AATTAAGAGT TTAATAATGA 001280
001281 ATTAACTAAT GATTTAAACA GGTGGATAAG ACTAACACTG AACCAATGAT TTTAAGTAAA TCTAAATACA TAAATCCCCC 001360
001361 CAAATTATTA ATCTATGTTG TTTACTAAGA AGTGTATTAA AATGATATTG AAAAAGTTTG CTTTGGGAAA GAGCTAGAAG 001440
001441 TTAGAAGGTC TAGGTTCAAA TCCCGCCTCT ACTCCATCCT TGACTAAGAT GTTGGACCCA TCACCTCAAC TTTCCTTGGG 001520
001521 TCTTTTTGCC CAGACATGAC CCGATGACAC AGAGCTTACC TGGACCTCCA CAATAGTAAA TAGAACAGGG CCAGCAAACC 001600
001601 AAAATTTGTT GAGTCCTTTA GAATTAAGTA GCTTAGATAA ATTTTCATCA AAATCTTTAT ATAGTAGGGA ATAGAAAAAA 001680
001681 GTCAATTCTG TTTTATTTGA GGATGTATGA ATATGTTACC ATTTTTCAGA CTCTGATTTA CCTTCCAATT ATTGTTTATT 001760
001761 GGGGTCATTG TAAATTAGTT ATCATTTTTT GAATACACAT TCACTGCTGA CAAAGTGGTG AAGCCAGAAG TTATGTTTGA 001840
001841 CCAGGGAAGA TTATGACCCT CAAAGGAGAA AAATTCACAG GGGGTAGTTG ATTATTGGTG GAATGGAGTG AGAGTGAATT 001920
001921 CCTTAAAAGT TTAAACGAAA GCAGAACTAT ATTCATATCA TGGAGGGAAC TTAGTTTCTA ATATGATGAA CTATTGCCCC 002000
002001 AAGTCATGAC AATACCTTGC TCTCTGGAAG AGAATGAGTG AGTTTTTCAT CCGCCAAGAT ACACACTCTA TATTTCCAAC 002080
002081 CATCACATCT GCCTTGCAGG CTGACTGAAC CCAGAGCAAA TCAATCACAA AAGTTAATCC AAAAGACTTC CCTTCAGCTG 002160
002161 CTGGAAATCA GTCATCACAT CTGTGAAAAG AGTGCTAGTT ATAACAAATG AGATCACAAA TTTGACCATT TTATTAGACA 002240
002241 CCCTCTATTA GTGTTAACAG ACAAAGATGA AGGTTAAGTT GAAATCAAAT TGAAATCTTC TTCCCTCTGT ACAGATTGCA 002320
002321 ATATCTGATA ATACCCTCAA CTTTCTTGGT GCAAATTAAT TGCCTGGTAC TCACAGTCCA GTGTTAACAG GCAATAATGG 002400
002401 TGTGATTCCA GAGGAGAGTA CTAGGTGGCA GGAAAATAAA TGAGATTAGC AGTATTTGAC TTGGAGCCAT AGGCATCAAT 002480
002481 TCTGCTCCAG CTGTCGACCA GGTTCTAAAA ACAAGACTCG GAGCAGCTTT TGCTCTTGCT AGTGATGCAG GGCCAGGAGA 002560
002561 GCCCCCACAC TCTGCATTTG CAGGTGTCCA TGAGGGGAAG CCACTCCTGC ATTTATCCTG TGAGTGGAGA AGCTCAGAGG 002640
002641 AATGAGGACA TTCCAACAGG GTATCAGAAT TCTCTTTTGT TTATGCTAAT TGACAGCAGG AACATCACCA TCTTGGACAA 002720
002721 ACACCACCAT TTTAAGTTCT CTTTTATTTA AAAACTGCCT AAATCCAGCC CCAAAACATC AGCCTAATGG CTATTGTCAG 002800
002801 CATAATCAGA AACATTCCAA CCCTAAGATA AACACCCCTC TGGCCAGAAA TATGCCGACC CCGAGACAGC CTCCCCTCCG 002880
002881 ACCAGAGACA TTCCAAACCC GCAGTAAACT TTCCTTCACA TGGAAACATT CCAAACCTAC AAAAAGCTTC CCTCTTCCTA 002960
002961 AACCCTTAAA TATCCTTAGT CTGCAAGAGA GAATGCTCCT GACTGAAATC AGCCAGAAGC CCCTCTCAGG TTTATTCTCC 003040
003041 AAAATAAACC TGTCTTTGAC TGTTGAGCCA AAAAAAAAAA AAAAAAA
000081 CTCCTGCCCT CAAACATCAG ACTCCAGGTT CTTCAGCTTT TGGACTCTTG GACCTACCCC CCGAGTGGTT TGCCAGGGGC 000160
000161 TCTCAGGCCT TCGGCTACAG ACTGAGGGCT GCATTATCAG CTTTCCTACT TTTGAGGTTT TGGGACTTTA CTGGCTTTCT 000240
000241 TGCTCCTCAA CTTGCAGATG GCCTGTTGTG GGACCTCACC TTGTGATCAT GTACATGAGG GAAATACACA CCCCTCCCAG 000320
000321 GGATGATGGA AGGTTAAGGT CCTAACACCT CCTGCACATC TGAGCAGCTG CACATTGAAC CAGATAGTCC TGGAATGTGG 000400
000401 GAAAACAGAG GCAGACTCAA GAGTCTGGAA CATTATTTTA GGATCACACA AAAAAGATAC ATAATTTTCA TAGAATGATA 000480
000481 CTGAAAGCAT CTCAAAAATA AAATCACGAG TATCTGCAGA TCACTATGAG ACTGGACTGG AACATTACCT TCAGACACAT 000560
000561 TGATATGACT ACATGCTGGA CATTTTCTTG CGGAAATCCA AAAGAAATCC CCATTTTCTT GCAGAAATCT AAAATAATCT 000640
000641 CCCCTATGTG CAAGTCAGAC TGAGCACCAC TCCCAAGACC ATGACCTCCC CTGCAGCCCT GCTCCTTCCC ACTCACCTCT 000720
000721 CCTCTTGAGA AAGCCACCTC CCACCACCCA GTCTGCAGTG CCAGAAAACT GGAAACCAGC CCCTAAGCTG CTTTCACCTT 000800
000801 CGGCCCATTT CTCACTAGCC AGCCTCTCCC ACGGCCTCCC CAGTTTCTTC AAATACACCC CCTCCACTAT TCACCATACT 000880
000881 GCCACCGTGA TTTATTTACA ACTTTTTGTC CGGATTACCT CAGTAGCCTT CTAATTGTCC CCTTTGCATC TAAAGTAGCC 000960
000961 CCTCTCATCC CCCAAATCTT ACGTCACTCT TCTACATAAT TCTGGCTTTC CATGACCCAT AAACCACATT TCTCAAGTGT 001040
001041 GCTCTATGCT GGCTTGAATA TGTTAATAAT CTTAATTCTA CTTTTAGTGC AATTTTCTTA GAGCTGGCAT CACTTTCATC 001120
001121 ATGACGTGAG AACTTACTAG AGATAGGCAA TGATGACTCA CAGTCAAGCC ACATGTCATA TGCTGCAGAC ATCTGGACTG 001200
001201 CTGCTTATTT GCAAATCCTT TTCTTCATAT TTTTCTCATT TGTAGCACTG GATCAATTCC AATTAAGAGT TTAATAATGA 001280
001281 ATTAACTAAT GATTTAAACA GGTGGATAAG ACTAACACTG AACCAATGAT TTTAAGTAAA TCTAAATACA TAAATCCCCC 001360
001361 CAAATTATTA ATCTATGTTG TTTACTAAGA AGTGTATTAA AATGATATTG AAAAAGTTTG CTTTGGGAAA GAGCTAGAAG 001440
001441 TTAGAAGGTC TAGGTTCAAA TCCCGCCTCT ACTCCATCCT TGACTAAGAT GTTGGACCCA TCACCTCAAC TTTCCTTGGG 001520
001521 TCTTTTTGCC CAGACATGAC CCGATGACAC AGAGCTTACC TGGACCTCCA CAATAGTAAA TAGAACAGGG CCAGCAAACC 001600
001601 AAAATTTGTT GAGTCCTTTA GAATTAAGTA GCTTAGATAA ATTTTCATCA AAATCTTTAT ATAGTAGGGA ATAGAAAAAA 001680
001681 GTCAATTCTG TTTTATTTGA GGATGTATGA ATATGTTACC ATTTTTCAGA CTCTGATTTA CCTTCCAATT ATTGTTTATT 001760
001761 GGGGTCATTG TAAATTAGTT ATCATTTTTT GAATACACAT TCACTGCTGA CAAAGTGGTG AAGCCAGAAG TTATGTTTGA 001840
001841 CCAGGGAAGA TTATGACCCT CAAAGGAGAA AAATTCACAG GGGGTAGTTG ATTATTGGTG GAATGGAGTG AGAGTGAATT 001920
001921 CCTTAAAAGT TTAAACGAAA GCAGAACTAT ATTCATATCA TGGAGGGAAC TTAGTTTCTA ATATGATGAA CTATTGCCCC 002000
002001 AAGTCATGAC AATACCTTGC TCTCTGGAAG AGAATGAGTG AGTTTTTCAT CCGCCAAGAT ACACACTCTA TATTTCCAAC 002080
002081 CATCACATCT GCCTTGCAGG CTGACTGAAC CCAGAGCAAA TCAATCACAA AAGTTAATCC AAAAGACTTC CCTTCAGCTG 002160
002161 CTGGAAATCA GTCATCACAT CTGTGAAAAG AGTGCTAGTT ATAACAAATG AGATCACAAA TTTGACCATT TTATTAGACA 002240
002241 CCCTCTATTA GTGTTAACAG ACAAAGATGA AGGTTAAGTT GAAATCAAAT TGAAATCTTC TTCCCTCTGT ACAGATTGCA 002320
002321 ATATCTGATA ATACCCTCAA CTTTCTTGGT GCAAATTAAT TGCCTGGTAC TCACAGTCCA GTGTTAACAG GCAATAATGG 002400
002401 TGTGATTCCA GAGGAGAGTA CTAGGTGGCA GGAAAATAAA TGAGATTAGC AGTATTTGAC TTGGAGCCAT AGGCATCAAT 002480
002481 TCTGCTCCAG CTGTCGACCA GGTTCTAAAA ACAAGACTCG GAGCAGCTTT TGCTCTTGCT AGTGATGCAG GGCCAGGAGA 002560
002561 GCCCCCACAC TCTGCATTTG CAGGTGTCCA TGAGGGGAAG CCACTCCTGC ATTTATCCTG TGAGTGGAGA AGCTCAGAGG 002640
002641 AATGAGGACA TTCCAACAGG GTATCAGAAT TCTCTTTTGT TTATGCTAAT TGACAGCAGG AACATCACCA TCTTGGACAA 002720
002721 ACACCACCAT TTTAAGTTCT CTTTTATTTA AAAACTGCCT AAATCCAGCC CCAAAACATC AGCCTAATGG CTATTGTCAG 002800
002801 CATAATCAGA AACATTCCAA CCCTAAGATA AACACCCCTC TGGCCAGAAA TATGCCGACC CCGAGACAGC CTCCCCTCCG 002880
002881 ACCAGAGACA TTCCAAACCC GCAGTAAACT TTCCTTCACA TGGAAACATT CCAAACCTAC AAAAAGCTTC CCTCTTCCTA 002960
002961 AACCCTTAAA TATCCTTAGT CTGCAAGAGA GAATGCTCCT GACTGAAATC AGCCAGAAGC CCCTCTCAGG TTTATTCTCC 003040
003041 AAAATAAACC TGTCTTTGAC TGTTGAGCCA AAAAAAAAAA AAAAAAA
