Difference between revisions of "DLEU2L"

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(Expression)
(Function)
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===Function===
 
===Function===
[[File:LeXis functions as a ceRNA of β-catenin.jpg|right|thumb|LeXis functions as a ceRNA of β-catenin([https://www.ncbi.nlm.nih.gov/pubmed/28744406 (Wang G 2017)])]]
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Please input evolution information here.
LeXis binds with heterogeneous ribonucleoprotein Raly which contains both an RNA-binding domain and a leucine-zipper coiled domain, to affect the expression of srebf2 gene, resulting to the change of the level of SREBP-2(sterol regulatory element-binding protein), to modulate cholesterol metabolism([https://www.ncbi.nlm.nih.gov/pubmed/27251289 (Sallam T 2016)]).
 
 
 
LeXis positively regulates CTNNB1 expression by functioning as a ceRNA against miR-199a to promote osteosarcoma growth([https://www.ncbi.nlm.nih.gov/pubmed/28744406 (Wang G 2017)]).
 
  
 
===Disease===
 
===Disease===

Revision as of 05:46, 28 July 2019

Annotated Information

Name

Approved symbol: DLEU2L

Approved name: deleted in lymphocytic leukemia 2 like

HGNC ID: HGNC:13225

Previous names: BCMS upstream neighbor-like

Alias symbols: BCMSUNL

RefSeq ID: NR_002771

Characteristics

Chromosomal localization of the BCMSUNL gene((Mertens D 2000))

BCMSUNL located at 1p22-p31, not part of the critical deletion region of 1p22 in MCLs. BCMSUNL has intronless, lacks exon 2 and shows 90.3% homology on the nucleic acid levelcompare with BCMSUN.

Expression

Expressed in peripheral blood lymphocytes from healthy donors as well as B‐CLL and MCL tumors((Mertens D 2000)) .

Regulation

Please input evolution information here.

Function

Please input evolution information here.

Disease

  • osteosarcoma
  • colon adenocarcinoma [1]

Evolution

Please input evolution information here.

Labs working on this lncRNA

  • No.4 Department of Orthopedics, Cangzhou Central HospitalCangzhou, Hebei Province, China
  • Department of Pathology and Laboratory Medicine, Howard Hughes Medical Institute, University of California, Los Angeles, California 90095, USA.

References

  1. Shahriyari L. Effect of normalization methods on the performance of supervised learning algorithms applied to HTSeq-FPKM-UQ data sets: 7SK RNA expression as a predictor of survival in patients with colon adenocarcinoma. Brief Bioinform. 2017 Nov 3. doi: 10.1093/bib/bbx153.

Annotation originally sourced from lncRNAdb.