Difference between revisions of "TP53TG1"

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(Created page with "==Annotated Information== ===Approved Symbol=== TP53TG1 ===Approved Name=== TP53 target 1 (non-protein coding) ===Previous Symbols=== TP53AP1 ===Synonyms=== H_RG012D21.9, LINC...")
 
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''TP53TG1'', a p53-induced lncRNA, plays a vital role in the progression of human cancers.
 
==Annotated Information==
 
==Annotated Information==
−
===Approved Symbol===
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Approved Symbol: ''TP53TG1''
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TP53TG1
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−
===Approved Name===
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Approved Name: TP53 target 1 (non-protein coding)
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TP53 target 1 (non-protein coding)
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−
===Previous Symbols===
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Previous Symbols: TP53AP1
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TP53AP1
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−
===Synonyms===
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Synonyms: H_RG012D21.9, LINC00096
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H_RG012D21.9, LINC00096
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−
===Chromosome===
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Chromosome：7q21.1
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7q21.1
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−
===RefSeq ID===
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RefSeq ID：NR_015381
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NR_015381
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−
===OMIM ID===
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OMIM ID：616403
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616403
+
 
−
===Ensembl ID===
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Ensembl ID: ENSG00000182165
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ENSG00000182165
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===pubmed IDs===
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LncBook ID: HSALNT0289272
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9713990
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===Characteristics===
 +
''TP53TG1'' , a long intergenic non-protein-coding RNA with 751 nt in length, was revealed to exert a tumor-suppressor feature in human cancer <ref name="ref1" />.
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===Function===
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[[File:TP53TG1exp.png|right|thumb|400px|TP53TG1 expression levels in NSCLC tissues and cells.<ref name="ref3" />.]]
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* It is reported that ''TP53TG1'' under glucose deprivation might facilitate cell proliferation and migration by affecting the expression of glucose metabolism related genes in glioma<ref name="ref2" />.
 +
 
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* ''TP53TG1'' increased the sensitivity of NSCLC cells to cisplatin by modulating miR-18a/PTEN axis, elucidating a novel approach to boost the effectiveness of chemotherapy for non-small cell lung cancer (NSCLC)<ref name="ref3" />.
 +
 
 +
===Regulation===
 +
 
 +
===Diseases===
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Glioma<ref name="ref2" />.
 +
 
 +
Non-small cell lung cancer<ref name="ref3" />.  
 +
 
 +
===Expression===
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''TP53TG1'' level was downregulated in cell lung cancer (NSCLC) tissues and cell lines<ref name="ref3" />.
 +
 
 +
{| class='wikitable' style="text-align:center"
 +
|-
 +
! | Experiment
 +
! | Sense primer
 +
! | Antisense primer
 +
|-
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| rowspan="1"|Quantitative real-time PCR
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| | 5'-ACGAAGGTACCCAACCCTCT- 3'
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| | 5'-GGTGTAAGTGTTCGCCTGGT- 3'<ref name="ref3" />
 +
|}
 +
 
 +
===Evolution===
 +
 
 +
 
 +
==Labs working on this lncRNA==
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* Department of Radiology, The First Affiliated Hospital of Zhengzhou University, No. 1 Jianshe East Road, Zhengzhou 450052, China.
 +
==References==
 +
<references>
 +
<ref name="ref1"> Diaz-Lagares A, Crujeiras AB, Lopez-Serra P, Soler M, Setien F, Goyal A, et al. Epigenetic inactivation of the p53-induced long noncoding RNA TP53.
 +
</ref>(1)
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<ref name="ref2"> Chen X, Gao Y, Li D, Hao B, Cao Y. LncRNA-TP53TG1 participated in the stress response under glucose deprivation in glioma. J Cell Biochem.
 +
2017;118(12):4897–904
 +
</ref>(2)
 +
<ref name="ref3"> Xiao H, Liu Y, Liang P, Wang B, Tan H, Zhang Y, Gao X, Gao J. TP53TG1 enhances cisplatin sensitivity of non-small cell lung cancer cells through regulating miR-18a/PTEN axis. Cell Biosci. 2018 Mar 22;8:23.
 +
</ref>(3)
 +
</references>
 
===Sequence===
 
===Sequence===
 
>gi|168823573|ref|NR_015381.1| Homo sapiens TP53 target 1 (non-protein coding) (TP53TG1), long non-coding RNA
 
>gi|168823573|ref|NR_015381.1| Homo sapiens TP53 target 1 (non-protein coding) (TP53TG1), long non-coding RNA
 
<dnaseq>CCCTGTCTCCAGTGGGCGTCTTGGGCCCCGGCTCTATTCTGGGCTGCGGGCCTGGGAAGGGCTCGCCGGGTGCCAAATGAGCTGTCCTAACTCTGCGGGGCTGCAGCTTCCTGCATGATGCTGGGGAGCTTGGCGCCTGACCCAGGATCTAGAAGGCACTCTGGGCAGGCCGCGCTCCGCCCACGAAGGTACCCAACCCTCTGGGATAGATGCAGGAAGCGATGGTTAAGACCCATTTTCACCCAACTTCTCGCCGCAGGTCTGGCTTACCACACGCTCCTCCCCATTCCCAGTGAGCCGCTTTTTGCAGCACCAGGCGAACACTTACACCAGTGCTTTGTAAAGGAATCTTATTGTCCACCCCGTGTCTTGGCAAAAGAACAGTGATCACACAGATTCCTACTTGGGCTCTTTCCTTTAATCTTCGGAGGCTGAGTTTGCCCAACTCAGGTTTAACCACCAAGGACTCTGAGAGCTGGCAGGTCTGAGTAACCCTGGTAACAATTCTCTTCACCTTATCAAAACCTGAGCTAAAACCAATGCATCAGCTGATGATGACAGCAGAGAGTGGCAGGGCTGAGGACCCAAAGTCATTTCCCAGGCTGGCGGAGAATAAACTGCCAGGGAGAAGAATGAGAAGACAGGAGACAAACTGTTTGGAAAGCTAAATCTTCCCTCTTAATGAATAAAGGTTTTTGCCTTGTCTTAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA</dnaseq>
 
<dnaseq>CCCTGTCTCCAGTGGGCGTCTTGGGCCCCGGCTCTATTCTGGGCTGCGGGCCTGGGAAGGGCTCGCCGGGTGCCAAATGAGCTGTCCTAACTCTGCGGGGCTGCAGCTTCCTGCATGATGCTGGGGAGCTTGGCGCCTGACCCAGGATCTAGAAGGCACTCTGGGCAGGCCGCGCTCCGCCCACGAAGGTACCCAACCCTCTGGGATAGATGCAGGAAGCGATGGTTAAGACCCATTTTCACCCAACTTCTCGCCGCAGGTCTGGCTTACCACACGCTCCTCCCCATTCCCAGTGAGCCGCTTTTTGCAGCACCAGGCGAACACTTACACCAGTGCTTTGTAAAGGAATCTTATTGTCCACCCCGTGTCTTGGCAAAAGAACAGTGATCACACAGATTCCTACTTGGGCTCTTTCCTTTAATCTTCGGAGGCTGAGTTTGCCCAACTCAGGTTTAACCACCAAGGACTCTGAGAGCTGGCAGGTCTGAGTAACCCTGGTAACAATTCTCTTCACCTTATCAAAACCTGAGCTAAAACCAATGCATCAGCTGATGATGACAGCAGAGAGTGGCAGGGCTGAGGACCCAAAGTCATTTCCCAGGCTGGCGGAGAATAAACTGCCAGGGAGAAGAATGAGAAGACAGGAGACAAACTGTTTGGAAAGCTAAATCTTCCCTCTTAATGAATAAAGGTTTTTGCCTTGTCTTAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA</dnaseq>

Revision as of 02:40, 1 August 2019

TP53TG1, a p53-induced lncRNA, plays a vital role in the progression of human cancers.

Annotated Information

Approved Symbol: TP53TG1

Approved Name: TP53 target 1 (non-protein coding)

Previous Symbols: TP53AP1

Synonyms: H_RG012D21.9, LINC00096

Chromosome：7q21.1

RefSeq ID：NR_015381

OMIM ID：616403

Ensembl ID: ENSG00000182165

LncBook ID: HSALNT0289272

Characteristics

TP53TG1 , a long intergenic non-protein-coding RNA with 751 nt in length, was revealed to exert a tumor-suppressor feature in human cancer [1].

Function

TP53TG1 expression levels in NSCLC tissues and cells.[2].
  • It is reported that TP53TG1 under glucose deprivation might facilitate cell proliferation and migration by affecting the expression of glucose metabolism related genes in glioma[3].
  • TP53TG1 increased the sensitivity of NSCLC cells to cisplatin by modulating miR-18a/PTEN axis, elucidating a novel approach to boost the effectiveness of chemotherapy for non-small cell lung cancer (NSCLC)[2].

Regulation

Diseases

Glioma[3].

Non-small cell lung cancer[2].

Expression

TP53TG1 level was downregulated in cell lung cancer (NSCLC) tissues and cell lines[2].

Experiment Sense primer Antisense primer
Quantitative real-time PCR 5'-ACGAAGGTACCCAACCCTCT- 3' 5'-GGTGTAAGTGTTCGCCTGGT- 3'[2]

Evolution

Labs working on this lncRNA

  • Department of Radiology, The First Affiliated Hospital of Zhengzhou University, No. 1 Jianshe East Road, Zhengzhou 450052, China.

References

  1. ↑ Diaz-Lagares A, Crujeiras AB, Lopez-Serra P, Soler M, Setien F, Goyal A, et al. Epigenetic inactivation of the p53-induced long noncoding RNA TP53.
  2. ↑ 2.0 2.1 2.2 2.3 2.4 Xiao H, Liu Y, Liang P, Wang B, Tan H, Zhang Y, Gao X, Gao J. TP53TG1 enhances cisplatin sensitivity of non-small cell lung cancer cells through regulating miR-18a/PTEN axis. Cell Biosci. 2018 Mar 22;8:23.
  3. ↑ 3.0 3.1 Chen X, Gao Y, Li D, Hao B, Cao Y. LncRNA-TP53TG1 participated in the stress response under glucose deprivation in glioma. J Cell Biochem. 2017;118(12):4897–904

Sequence

>gi|168823573|ref|NR_015381.1| Homo sapiens TP53 target 1 (non-protein coding) (TP53TG1), long non-coding RNA

000001 CCCTGTCTCC AGTGGGCGTC TTGGGCCCCG GCTCTATTCT GGGCTGCGGG CCTGGGAAGG GCTCGCCGGG TGCCAAATGA 000080
000081 GCTGTCCTAA CTCTGCGGGG CTGCAGCTTC CTGCATGATG CTGGGGAGCT TGGCGCCTGA CCCAGGATCT AGAAGGCACT 000160
000161 CTGGGCAGGC CGCGCTCCGC CCACGAAGGT ACCCAACCCT CTGGGATAGA TGCAGGAAGC GATGGTTAAG ACCCATTTTC 000240
000241 ACCCAACTTC TCGCCGCAGG TCTGGCTTAC CACACGCTCC TCCCCATTCC CAGTGAGCCG CTTTTTGCAG CACCAGGCGA 000320
000321 ACACTTACAC CAGTGCTTTG TAAAGGAATC TTATTGTCCA CCCCGTGTCT TGGCAAAAGA ACAGTGATCA CACAGATTCC 000400
000401 TACTTGGGCT CTTTCCTTTA ATCTTCGGAG GCTGAGTTTG CCCAACTCAG GTTTAACCAC CAAGGACTCT GAGAGCTGGC 000480
000481 AGGTCTGAGT AACCCTGGTA ACAATTCTCT TCACCTTATC AAAACCTGAG CTAAAACCAA TGCATCAGCT GATGATGACA 000560
000561 GCAGAGAGTG GCAGGGCTGA GGACCCAAAG TCATTTCCCA GGCTGGCGGA GAATAAACTG CCAGGGAGAA GAATGAGAAG 000640
000641 ACAGGAGACA AACTGTTTGG AAAGCTAAAT CTTCCCTCTT AATGAATAAA GGTTTTTGCC TTGTCTTAAA AAAAAAAAAA 000720
000721 AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA A
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